@LabJiang

We use brain organoid and chimeric-brain platforms to uncover disease mechanisms and engineer human microglia for brain repair.

 Piscataway, NJ 08854
cbn.rutgers.edu/peng-jiang-lab/577-peng-jiang-lab-news
Joined February 2020
  • Tweets349
  • Following505
  • Followers628
44Media
Peng Jiang Lab retweeted
John Lukens@LukensJohnROct 13
A cross-species AAV platform for precise microglial interrogation: @NeuroCellPress cell.com/neuron/fulltext/S08…
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When organoids meet chimeric brains! @Nature nature.com/articles/s41586-0…

Developmental xenocortication using human-derived organoids in mice

Nature - Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

nature.com
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Peng Jiang Lab retweeted
Gan Lab@LiGanLabAug 11
🎉New in Neuron! We identified that microglia-derived soluble DLK1 links aging to hypomyelination. In mouse and human iPSC models, telomere shortening drives microglial senescence, ↑sDLK1, and impaired oligodendrocyte maturation and neuronal activity. cell.com/neuron/fulltext/S08…
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Peng Jiang Lab retweeted
Gan Lab@LiGanLabAug 1
From @Nature : The aging human brain is more dynamic than we thought. Somatic mutations revealed marrow-derived cells in every human brain studied, sometimes forming a large share of microglia, Clonal hematopoiesis was also linked to a lower risk of AD. nature.com/articles/s41586-0…

Somatic mutations reveal the ontogeny of microglia in human ageing

Nature - A widespread influx of myeloid cells into the healthy human brain contributes to the pool of human microglia and becomes common with ageing.

nature.com
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Peng Jiang Lab retweeted
IdoAmitLab@IdoAmitLabJul 30
Beautiful study lead by Julia, Howard, Siddhartha and co. follows the ontogeny of microglia in human aging nature.com/articles/s41586-0…

Somatic mutations reveal the ontogeny of microglia in human ageing

Nature - A widespread influx of myeloid cells into the healthy human brain contributes to the pool of human microglia and becomes common with ageing.

nature.com
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A truly groundbreaking study showcasing the transformative potential of human glial chimeric brain models for in vivo AAV evolution. Combining human glia-selective capsids with glymphatic delivery represents a landmark advance toward precise CNS gene therapy!
Nature Biotechnology
@NatureBiotechJul 8
Efficient targeting of human glial progenitor cells in vivo with engineered AAV vectors and glymphatic delivery nature.com/articles/s41587-0…
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It also makes me wonder—what if this powerful strategy could be extended to engineer AAVs that specifically target human microglia?
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Well said on the role of somatic mutations in myeloid cells in Alzheimer's disease! (cell.com/trends/molecular-me…) The CSF2RB A455D variant from our study is also a promising example. More studies using chimeric brain models with human microglia carrying somatic mutations are needed.
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Can grafted microglia be harnessed for neuronal replacement? Motivated by their unique properties for cell-based therapies, we explored the direct conversion of human microglia into neurons. Excited to share our new study on bioRxiv.
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Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains biorxiv.org/content/10.64898…
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All models have limitations. Animal models are indispensable for neuroscience research. Meanwhile, chimeric brain models provide opportunities to study human neural cells with advanced maturation and functional integration in an in vivo brain environment cell.com/cell-metabolism/ful…
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Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies: Neuron cell.com/neuron/fulltext/S08…
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Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived ne... sciencedirect.com/science/ar…
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Thrilled to share our new study published in @CellReports! 🎉 Led by @jin_mengmeng, @ZiyuanMa5, and Haiwei Zhang. Grateful for a wonderful collaboration with Dr. Steve Goldman, a pioneer in chimeric brain models and glial biology. cell.com/cell-reports/fullte…

Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions

Jin et al. develop chimeric mouse brains containing human microglia, astroglia, oligodendroglia, and neurons, enabling direct interrogation of human neuron-glia interactions in vivo. These models...

cell.com
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In this study, we developed a series of new chimeric brain models by combining different transgenic mouse lines with co-transplantation of human microglia and neural cells, enabling in vivo studies of human neuro–glia and glia–glia interactions.
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Thank you for highlighting our work!
Gan Lab@LiGanLab26 Nov 2025
New study from Jiang group gives clues to Down syndrome patients' resilience to AD: DS-linked myeloid mutation CSF2RB A455D protects engrafted human microglia against tau by suppressing IFN signaling, boosting phagocytosis, & reducing microglial senescence nature.com/articles/s41593-0…
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Peng Jiang Lab retweeted
John Lukens@LukensJohnR24 Nov 2025
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease @NatureNeuro nature.com/articles/s41593-0…
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An idea we started in 2019 is now published in @NatureNeuro! Excited to share our new study: rdcu.be/eRvdA Congrats to Mengmeng Jin @jin_mengmeng and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!
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Explore our new study here 👇, and Happy Thanksgiving to all! Author’s link: rdcu.be/eRvdA Rutgers Today article @RutgersU_News @RutgersSAS @RutgersU: rutgers.edu/news/inspired-fa…
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Peng Jiang Lab retweeted
John Lukens@LukensJohnR21 Nov 2025
Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.w… @alzdemjournals
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