Studying mechanisms of developmental clocks and timers
FMI Basel, Switzerland
Joined April 2021
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Out now – our paper using temporally highly-resolved expression profiling and mathematical modeling to detect dynamic #miRNA expression in #C. elegans larvae and determine the mechanisms: doi.org/10.1093/nar/gkae115 @FMIScience 1/8
Now out in @MolSystBiol 👇 - predicting protease activity quantitatively from a one-shot experiment as a way to engineer substrate half-lives and characterize proteases. Tweetorial (from the preprint) here: xitter.cf/LabGrosshans/status/17…
@LabGrosshans develop a quantitative model for protease cleavage specificity and cooperativity of protease sites ➡️ embopress.org/doi/full/10.10…
Born out of a project on RNA silencing and thus funded, in part, by the @NCCR_RNADisease - thank you 🙏!
Join us in our Proteomics Platform. And if you'd like a peek at some of the fun stuff we are doing, take a look at our latest paper, combining proteomics and modelling to assess and predict quantitatively protease substrate specificity embopress.org/doi/full/10.10… (more details later)
The Proteomics Platform at the FMI is seeking a skilled Proteomics Specialist who is passionate about cutting-edge technologies in multi-disciplinary projects.
Apply by November 30, 2024 at fmi.ch/education-careers/pos…
Very cool 👇
🔬✨ New insights into tissue regeneration! Our study uncovers a novel mechanochemical mechanism in Hydra, revealing how mechanical forces and Wnt signaling work together to create intricate tissue patterns. #Cnidarians #Hydra #Biology #Regeneration biorxiv.org/content/10.1101/…
Grosshans Lab retweeted
We are recruiting a postdoctoral fellow @DiazCuadrosLab! Please spread the word! Check out our lab website for more information: diazcuadroslab.org
Grosshans Lab retweeted
Deadlines are approaching for @KeystoneSymp #NonCodingRNA Biology: New Roles and Diversity, this January in Keystone! See scholarship, abstract and discount reg dates: keysym.us/KSncRNA25 #KSncRNA25
Grosshans Lab retweeted
We have a 4-year PhD position in our lab to study RNA splicing regulation in collaboration with @YiliangDing @biouea @alperakaylab @NorwichRNAClub #RNA #Celegans #PhDposition biodtp.norwichresearchpark.a…
Always a pleasure when alumni visit the lab, bringing back lots of fond memories. Thanks also for sharing the latest insights into miRNA decay, @mdlmata !
Grosshans Lab retweeted
Register now & submit abstracts (deadline Dec 8) for the #Swiss #RNA Workshop on January 24, 2025, starting at 09:15 @unibern.
Short talks selected from abstracts. Registration free of charge. See the next tweet for sponsors. swissrnaws.dcbp.unibe.ch
Please help spread the word!
Grosshans Lab retweeted
Nobel Laureate and HMS Professor Gary Ruvkun shared lighthearted tales about his start, a science revolution, and the power of worms.
Grosshans Lab retweeted
News Report of Swiss National Radio (@srfnews) on the #miRNA #NobelPrize featuring NCCR PIs Helge Grosshans (@LabGrosshans, @FMIscience) and Markus Stoffel (@ETH_DBIOL, @ETH_en):
srf.ch/audio/echo-der-zeit/m…
Could not agree more - without "bluesky" fundamental research, no translational research, no clinical/medical application.
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Grosshans Lab retweeted
We’re looking for a postdoc with a strong background in AI, biophysics, modeling or related.
Please forward to potential candidates and RT 🙏
More details below 👇
Postdoc Opportunity👉Join @Guillaume_Diss' group to study how the sequence of a protein determines its function! In this role, you'll leverage large datasets to train generative models to predict protein-protein interaction affinity from sequence. Apply at fmi.ch/education-careers/pos…
We will be hiring 👇 - apply if you are interested in understanding mechanisms of developmental timing using genomics, genetics, molecular biology, quantitative time lapse imaging, modelling, ...
How timely - nobelprize.org/prizes/medici…: Ambros and Ruvkun discovered miRNAs by studying the developmental timing pathway on which this PhD project focuses - the video 👇shows the consequences of mutating the let-7 miRNA, dx.doi.org/10.1016/j.devcel.…
Grosshans Lab retweeted
It couldn’t be a better day to apply for a PhD in the @LabGrosshans! Amazing environment and great mentor!
Excellent choice - congratulations, Victor and Gary, for this deserved recognition of your breakthrough work!
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Grosshans Lab retweeted
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.