@TsiairisLab

Lab of Charisios Tsiairis Researching Self Organising Cellular Systems @FMIScience

 FMI Basel
fmi.ch/research-groups/groupleader.html?group=137
Joined August 2020
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Ever wondered how a tiny Hydra blob figures out where its head goes? Turns out, it's not just chemistry — it's feeling the stretch! Check out 👉 Mechanochemical patterning localizes the organizer of a luminal epithelium science.org/doi/10.1126/scia… #Hydra #morphogenesis #biophysics

Mechanochemical patterning localizes the organizer of a luminal epithelium

A feedback loop between Wnt signaling and mechanical tissue stretching drives pattern formation in Hydra epithelia.

science.org
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Tsiairis Lab retweeted
FMI science@FMIscience
24 Sep 2025
Now in @Dev_journal: Researchers in the @TsiairisLab discovered how Hydra cells decide to form stinging tentacles or an anchoring foot, revealing key rules of body patterning. Read more at fmi.ch/news-events/articles/…
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Ever wondered how metabolism regulates embryonic development? Our recent work demonstrates that metabolism has a signaling module controlling the tempo of embryonic axis segmentation. science.org/doi/10.1126/scia…

A noncanonical role of glycolytic metabolites controlling the timing of mouse embryo segmentation

Glycolysis plays a noncanonical signaling role via Wnt signaling to control the timing of mouse embryo axis segmentation.

science.org
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Tsiairis Lab retweeted
Development@Dev_journal
16 Sep 2025
Replying to @Dev_journal @jarofrnc @TsiairisLab
Read the Research Article “A transcription factor toggle switch determines differentiated epidermal cell identities in Hydra” here: journals.biologists.com/dev/…

A transcription factor toggle switch determines differentiated epidermal cell identities in Hydra

Highlighted Article: A transcriptional tug-of-war between Zic4 and Gata3 sculpts Hydra's body ends, revealing how cell fate and axial patterning are tightly coordinated.

journals.biologists.com
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Tsiairis Lab retweeted
Development@Dev_journal
16 Sep 2025
Hydra body axis balance: a fight between two transcription factors This Research Highlight showcases the work from Jaroslav Ferenc @jarofrnc, Marylène Bonvin, Panagiotis Papasaikas, Jacqueline Ferralli, Clara Nuninger and Charisios Tsiairis @TsiairisLab journals.biologists.com/dev/…
Figure 4: Phenotype rescue upon Zic4 and Gata3 double knockdown. Maximum projection confocal images of oral (A) and aboral (B) ends of animals after GFP RNAi (control), Zic4 or Gata3 RNAi, and Zic4+Gata3 RNAi. DNA in cyan, peroxidase activity in magenta and Nematocilin in orange. Panels on the right show magnifications of boxed areas on the left. Scale bars: 100μm. (C) Percentage of animals with ectopic peroxidase staining in tentacles upon Zic4 KD and double KD. (D) Percentage of animals with ectopic Nematocilin staining adjacent to the foot in Gata3 KD and double KD. ***P<0.001 (Fisher's exact test). (E,F) At the oral pole, Wnt signaling (black dot) activates Zic4 (orange) expression and thus basal disk identity. Without it, Gata3 dominates at the opposite end, leading to basal disk fate establishment (E). Experimentally depleting one of the factors results in ectopic cell fate acquisition at the opposite body end (F).

ALT Figure 4: Phenotype rescue upon Zic4 and Gata3 double knockdown. Maximum projection confocal images of oral (A) and aboral (B) ends of animals after GFP RNAi (control), Zic4 or Gata3 RNAi, and Zic4+Gata3 RNAi. DNA in cyan, peroxidase activity in magenta and Nematocilin in orange. Panels on the right show magnifications of boxed areas on the left. Scale bars: 100μm. (C) Percentage of animals with ectopic peroxidase staining in tentacles upon Zic4 KD and double KD. (D) Percentage of animals with ectopic Nematocilin staining adjacent to the foot in Gata3 KD and double KD. ***P<0.001 (Fisher's exact test). (E,F) At the oral pole, Wnt signaling (black dot) activates Zic4 (orange) expression and thus basal disk identity. Without it, Gata3 dominates at the opposite end, leading to basal disk fate establishment (E). Experimentally depleting one of the factors results in ectopic cell fate acquisition at the opposite body end (F).

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How does the #embryo build the backbone? We found that blocking a tiny molecular switch, Rac1, slows the #segmentation clock, and alters the size of spine segments. This could explain why people with #VACTERL syndrome have spinal defects…#preprint 👉 biorxiv.org/content/10.1101/…

Rac1 inhibition slows down the segmentation clock and increases the somite size

The presomitic mesoderm (PSM) is a transient embryonic tissue patterned along the anterior-posterior (A/P) axis of vertebrates that periodically generates somites at its anterior end. This process,...

biorxiv.org
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Just planted in Development 🌳 A transcription factor toggle switch determines differentiated epidermal cell identities in <i>Hydra</i> forest.biologists.com/landsc…
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Celebrating our award winning trainee talks from the recent ISRB Conference in Madison given by Daniela Münch, Anish Bose and Lauren Connolly, and proudly sponsored by Development @Dev_journal and Experimental Cell Research.
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Tsiairis Lab retweeted
FMI science@FMIscience
6 Feb 2025
We're hiring! Our IT Team is looking for a Linux Systems Engineer to support scientific computing and big data management. Apply here: fmi.ch/education-careers/pos…
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Tsiairis Lab retweeted
FMI science@FMIscience
16 Dec 2024
📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: fmi.ch/education-careers/pos…
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In our latest preprint, we reveal a surprising homeotic transformation where Hydra's foot turns into a tentacle! 🧬🔬 How and why does this happen? Find out now! 👇biorxiv.org/content/10.1101/…
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🔬✨ New insights into tissue regeneration! Our study uncovers a novel mechanochemical mechanism in Hydra, revealing how mechanical forces and Wnt signaling work together to create intricate tissue patterns. #Cnidarians #Hydra #Biology #Regeneration biorxiv.org/content/10.1101/…

Mechanochemical Patterning Localizes the Organizer of a Luminal Epithelium

The spontaneous emergence of tissue patterns is often attributed to biochemical reaction-diffusion systems. In Hydra tissue regeneration, the formation of a Wnt signaling center serves as a well-kn...

biorxiv.org
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It is a great meeting in Freiburg celebrating a pivotal moment in embryology! Behind this Nobel Prize are three unsung heroines: Hilde Mangold, Ethel Browne, and Hydra viridissima… #spemannmangold2024 #Hydra
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Tsiairis Lab retweeted
FMI science@FMIscience
2 Sep 2024
📢We're now accepting applications for our #PhD and #MDPhD programs! 🧬Join us in Basel, Europe's top hub for the #LifeSciences, and unleash your potential in a vibrant, international and supportive environment. 📅 Apply by November 15 at: fmi.ch/education-careers/pro…
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Ever wondered how stem cells ensure a balance between cell fates in the gut?⚖️Turns out, they’ve got rhythm!🎶Our latest research reveals that NOTCH-driven oscillations regulate stem/progenitor cell abundance and specify secretory subtypes. Check it out: biorxiv.org/content/10.1101/…
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Interested in applying for a fellowship to do a PhD @unil with my lab (bacterial synthetic biology) as a host? Send me a CV and a motivation letter till September 6th! unil.ch/ecoledoctoralefbm/en…
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🎉 Exciting news! Today marks the official opening of our new FMI building on the Novartis campus. This move strengthens our collaboration and commitment to pioneering biomedical research. Here’s to new horizons and shared innovation! 🏢🔬 #FMIOpening #Novartis #Innovation
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Had a fantastic time at #Cnidofest2024! Our lab enjoyed sharing our research and connecting with fellow cnidarian enthusiasts. Thanks to everyone for making it a memorable event! 🪼🔬  #Cnidarians #Hydra
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Check out our latest preprint on how Hydra cells regenerate missing parts. You might need to update your textbook knowledge on regeneration… biorxiv.org/content/10.1101/…

Progressive cell fate specification in morphallactic regeneration

Through regeneration various species replace lost parts of their body. This is achieved either by growth of new structures at the amputation side (epimorphosis), as is the case of axolotl limb...

biorxiv.org
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