@LabChiacchiera

Group Leader, Laboratory of Stem Cells and Cancer Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO),University of Trento

 Trento, Italy
cibio.unitn.it/956/laboratory-of-stem-cells-and-cancer-genomics
Joined February 2020
  • Tweets109
  • Following200
  • Followers213
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Are you looking for a #bioinformatics #pipeline to analyse #spike_in #ChIP_seq data? Check out our latest work now online in NAR Genomics and Bioinformatics!! Kudos to @BrexDavide and thanks to our collaborators!! doi.org/10.1093/nargab/lqae1…

SpikeFlow: automated and flexible analysis of ChIP-Seq data with spike-in control

Abstract. ChIP with reference exogenous genome (ChIP-Rx) is widely used to study histone modification changes across different biological conditions. A key

academic.oup.com
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Congratulations to Dr. @BrexDavide and Dr. Elisa Ferracci for earning their PhDs with honors. I’m so proud of you both! Your dedication, curiosity, and hard work have truly paid off.
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🧑‍🔬Davide Bressan is defending his #PhD thesis tomorrow: “Novel Insights into the Function of epigenetic Modifiers in Maintaining Liver Homeostasis and Preventing Tumorigenesis” 🏦 Room A205, Povo1 🗓️January, 30 at 2pm #phdlife #Cancer
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DPlab@pasini_lab20 Jan 2025
We are looking for different sceintific figures to work in our lab: Bioinformatic technologist Experimental Post-doc Experimantal post-graduate The full job description and related info can be found at this link: https://ieo-my.sharepoint.com/:b:/g/personal/ieo1616_ieo_it/Ecg4krXuYgFFj4mq4714lzIBQyypB3OS_1PZ1MkN-aEjBg?e=jneVov

ALT We are looking for different sceintific figures to work in our lab: Bioinformatic technologist Experimental Post-doc Experimantal post-graduate The full job description and related info can be found at this link: https://ieo-my.sharepoint.com/:b:/g/personal/ieo1616_ieo_it/Ecg4krXuYgFFj4mq4714lzIBQyypB3OS_1PZ1MkN-aEjBg?e=jneVov

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Eric Conway@conwayer113 Jan 2025
2-year computational postdoc position available to join our growing team to work on super-enhancers & transcription factors in AML @ucddublin. This project will use patient biopsies to identify 'epigenomic' sensitivities for this devastating cancer. conwaychromatinlab.com/team

Team — Conway Lab

conwaychromatinlab.com
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Mattia Pelizzola@MattiaPelizzola4 Sep 2024
We have developed Nanodynamo, a method based on @nanopore sequencing and mathematical modelling to study subcellular #RNA dynamics in triple-negative breast #cancer cells. The study is now out on @NatureComms doi.org/10.1038/s41467-024-5… rdcu.be/dSYRQ

Nanodynamo quantifies subcellular RNA dynamics revealing extensive coupling between steps of the...

Nature Communications - The life of RNAs is governed by a series of transcriptional and post-transcriptional steps. Here, authors developed Nanodynamo, an experimental and computational workflow...

nature.com
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Davide Bressan@BrexDavide29 Aug 2024
🚨 Excited to announce our new paper, “SpikeFlow: Automated and Flexible Analysis of ChIP-Seq Data with Spike-in Control”, now online in NAR Genomics and Bioinformatics! 🚨 🔗 academic.oup.com/nargab/arti… @LabChiacchiera @aromanel

SpikeFlow: automated and flexible analysis of ChIP-Seq data with spike-in control

Abstract. ChIP with reference exogenous genome (ChIP-Rx) is widely used to study histone modification changes across different biological conditions. A key

academic.oup.com
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The Roberts Lab@TheRobertsLab116 Jul 2024
Excited to share our new review in @NatRevDrugDisc covering ongoing efforts to therapeutically target chromatin remodelers focusing on SWI/SNF complexes. Congratulations to authors @HaydenMalone3 and Charlie! @stjudegraduate @stjuderesearch #swisnf (1/9) nature.com/articles/s41573-0…

Chromatin remodellers as therapeutic targets

Nature Reviews Drug Discovery - Mutations in genes that encode subunits of the SWI/SNF chromatin remodelling complexes are found in more than 20% of cancers as well as in certain neurodevelopmental...

nature.com
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DPlab@pasini_lab11 Jul 2024
Happy to share the latest work from the lab characterizing WNT and MYC oncogenic cooperation in gastric cancer through the regulation of lysosomal biogenesis and EPCAM levels. gastrojournal.org/article/S0…
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DPlab@pasini_lab6 Jul 2024
We are hiring a new head of our Genomic technological unit @IEOufficiale. A great opportunity, applications are open. Hurry up!!! research.ieo.it/careers-and-…
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Cell@CellCellPress15 May 2024
Now online! ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity dlvr.it/T6xRNC

ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

ARID1A loss in tumor cells triggers anti-tumor immunity via R-loop-derived cytosolic DNA and activation of the STING-type I interferon pathway, defining a molecular mechanism underlying ARID1A mutant...

cell.com
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The department has launched a call to fill a tenure-track assistant professor position in molecular biology (RTT, BIO/11). Send your applications in! 📅 May 16th, 12.00 ➡️ Apply here: lavoraconnoi.unitn.it/bando-… #ScienceJobs #research
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Cancer Cell@Cancer_Cell21 Mar 2024
Online Now: Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer dlvr.it/T4QM8L
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ZippoLab@alessio_zippo19 Mar 2024
We're thrilled to announce the publication of our most recent work about #Cancer #dormancy of #metastatic cells and #immune escape, now online @NatCom! Kudos to all the authors and collaborators! #Chromatin regulation matters, after all! nature.com/articles/s41467-0…

Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting...

Nature Communications - Metastasis arises from disseminated tumour cells (DTCs) while the underlying mechanism of DTCs plasticity remains underexplored. Here, the authors show that spatially...

nature.com
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Happy to share that our work on the oncogenic role of #Arid1a mutations is out in @ScienceAdvances! Kudos to all, especially Alessandro, @BrexDavide, Elisa, our collaborators @aromanel @pasini_lab! Thanks @AIRC_it and @WorldwideCancer for supporting us! science.org/doi/10.1126/scia…

Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic propert...

ARID1A loss in adult tissues affects genome integrity without altering enhancer-dependent transcriptional regulation.

science.org
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Molecular Cell@MolecularCell18 Jan 2024
Online Now: Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide dlvr.it/T1Yqkg
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Licio Collavin@liciocollavin16 Jan 2024
Registrations are OPEN for the "19th International p53 Workshop" in fascinating #Trieste, Italy. Great science, great location. icgeb.org/p53-conference-tri…
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DPlab@pasini_lab16 Jan 2024
Happy to share this new paper from our lab characterizinig the role of PCGF6 in regulating adult intestinal Tuft cell specification, uncovering RING1B and H2AK119ub1 independent in vivo properties... urlsand.esvalabs.com/?u=http…
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For the #PhDColloquia series, we are happy to host Francesca Ciccarelli (@fcicca) - Bart's Cancer Institute & @TheCrick for the seminar "Intrinsic and extrinsic drivers of #cancer #evolution." 📅 January 12th at 11 a.m. 🏦Room A204, Povo1 ℹ️ webmagazine.unitn.it/node/11…
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Fondazione Pezcoller@pezcoller29 Nov 2023
Very happy to announce the winner of the 2024 Pezcoller-Marina Larcher Fogazzaro- @EACRnews Women in Cancer Research Award 👏 Prof Maria Rescigno @maria_rescigno, @HumanitasMilano Read more: lnkd.in/d_s6jD4 #WomenInScience #CancerResearch👩‍🔬🏆
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