@KornmannLab

Our lab is interested in fundamental questions of cell biology and biochemistry of organelles. We use the powers of yeast genetics as a tool to discover importa

 Zürich, Switzerland
bc.biol.ethz.ch/research/kornmann
Joined November 2011
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🚨New preprint Alert🚨 Shared Structural Features of Miro Binding Control Mitochondrial Homeostasis biorxiv.org/content/10.1101/… If you want to get the gist follow the 🧵

Shared Structural Features of Miro Binding Control Mitochondrial Homeostasis

Miro proteins are universally conserved mitochondrial calcium-binding GTPases that regulate a multitude of mitochondrial processes, including transport, clearance and lipid trafficking. Miro binds a...

biorxiv.org
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Our new preprint is out! Phospholipids (PLs) are made a bit everywhere in cells and then transported by hosts of pathways we don't know of, a system full of redundancies and compensatory mechanisms. Here we set out to discover some of them. #followme biorxiv.org/content/10.1101/…

Rewiring phospholipid biosynthesis reveals robustness in membrane homeostasis and uncovers lipid...

Intracellular transport of lipids by Lipid Transport Proteins (LTPs) is thought to work alongside vesicular transport to shuttle lipids from their place of synthesis to their destinations. Whereas...

biorxiv.org
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Sabine brilliantly defended her PhD thesis. Huge congratulations! Last ETH-affiliated student of the lab, and of an era.
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We have a fully funded PhD project to study antifungal resistance in collaboration with Syngenta. Exciting opportunity to join us in Oxford and have a foot in the door of industry with twelve weeks at Syngenta Switzerland! findaphd.com/phds/project/tr…

Transposons to discover drug resistance mechanisms and their evolutionary cost at University of...

PhD Project - Transposons to discover drug resistance mechanisms and their evolutionary cost at University of Oxford, listed on FindAPhD.com

findaphd.com
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Our collaboration with the @LabStutz is out! SATAY screening unveils a role for a mysterious protease in resolving protein-DNA crosslinks. cell.com/molecular-cell/full…
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Here's the @KornmannLab v2019 🏴󠁧󠁢󠁥󠁮󠁧󠁿🇬🇧🇨🇳🇲🇫🇮🇳🇹🇼🇳🇱🇨🇭
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We're hiring a bioinfomartician/data scientist! You have the analytical skills, we have data, tons of them. Join a new and motivated group using transposon screening technologies in beautiful Oxford, and put your hand on that treasure trove of data! recruit.ox.ac.uk/pls/hrisliv…
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We are hiring postdocs! Excited about lipid exchange at membrane contacts and the idea of developing tools to actually "see" it happen? check recruit.ox.ac.uk/pls/hrisliv…
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We are looking for a research assistant. If you like the challenge of helping setting up a new research lab from scratch in Oxford and have a big impact on its future, then please apply! recruit.ox.ac.uk/pls/hrisliv…
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Our paper on CENP-F CRISPR mice is provisionally accepted in @PLOSGenetics . Congrats to @peterka_m ! In the mean time, the preprint is still available here biorxiv.org/content/10.1101/…

Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable...

CENP-F is a large, microtubule-binding protein that regulates multiple cellular processes including chromosome segregation and mitochondrial trafficking at cytokinesis. This multiplicity of function...

biorxiv.org
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We have received an Investigator Award grant from the Wellcome trust. We are therefore hiring. Get in touch if you want to work on the fascinating question of how lipid molecules traffic through the cell, and join the fantastic environment at Oxford Biochemistry.
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ANNOUNCEMENT: the laboratory is moving to the university of Oxford in the biochemistry department!
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Carmelina's review is out in Curr Opin Cell Biol. Read about the missing pieces of ER-mitochondria lipid exchange here: authors.elsevier.com/a/1YDcR…
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Carmelina's review had just been accepted in current opinion in cell biology. Congrats!
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Qian's paper on mechanical forces applied to cellular organelles has been published! jcs.biologists.org/content/1…
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Our latest preprint is out! It is about disrupting CENP-F/Miro interaction in mice using CRISPR/Cas9 genome-editing. Congratulations to Martin! biorxiv.org/content/early/20…
Our saturated transposon datasets are now available directly in @yeastgenome browser browse.yeastgenome.org/?loc=…
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Our latest paper is out. Mechanical forces induce mitochondrial fission. elifesciences.org/articles/3…

Mechanical force induces mitochondrial fission

Mechanically stimulating mitochondria causes them to divide via the recruitment of the mitochondrial fission machinery to the mechanically strained site, showing that intracellular organelles can be...

elifesciences.org
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Qian and Sebastian's paper is accepted in eLife. Congrats to them both!
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Our paper on Mcp1-Vps13 interaction at vacuole-mitochondria contacts is out in @JCellBiol . Congrats to Arun! jcb.rupress.org/content/earl…
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