Official account of Prof. Julian Knight's lab at @NDMOxford @OxfordMedSci and @HumanGeneticsOx Using functional genomics to understand the human immune system
Oxford, England
Joined February 2016
- Tweets257
- Following352
- Followers565
- Likes133
Knight Genetics retweeted
Glad to share our study showing how a common genetic variant impacts immune cell-cell communication and patient survival in pneumonia-associated sepsis, providing a framework for stratified therapy. Thanks to our funders and everyone involved.
nature.com/articles/s41467-0…
Knight Genetics retweeted
Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis dlvr.it/Sn0DBD
Knight Genetics retweeted
Congratulations to @KnightGenetics @andrewjkwok @eddiecg and team for their work on immune subsets in sepsis
Julian Knight and colleagues find that altered granulopoiesis and increases in immature immunosuppressive neutrophil subsets are associated with poor outcomes in some patients with sepsis. Read it here: rdcu.be/daDeU
nature.com/articles/s41590-0…
Knight Genetics retweeted
Our study on AS epigenomics has been covered by @GenomeWeb
Watch this space for link to paper and 🧵
Ankylosing Spondylitis Genomics Study Points to Genes, Pathways for Drug Discovery. Researchers analyzed transcriptomic and epigenomic features in immune cells from cases and controls alongside genetic risk data. ow.ly/Mxen104EMMw
Knight Genetics retweeted
For sepsis, quantifying immune dysfunction via whole blood RNA-seq or microarray led to accurate prediction of clinical outcomes across pathogens (including Covid) and age groups science.org/doi/10.1126/scit… #AI @ScienceTM @KnightGenetics @NDMOxford @OxfordMedSci @eddiecg
Knight Genetics retweeted
Study of enhancer use in macrophages in the innate immune response to endotoxin, from @pingzhangneho, @KnightGenetics & co, using histone mods, ATAC-seq and enhancer RNAs. They compare primary macrophages and those from pluripotent stem cells.
genomebiology.biomedcentral.…
ALT Example ATAC-seq peaks at one locus in different cell types
Knight Genetics retweeted
Last year we marked 100 years since women were admitted as full members of @UniofOxford by asking 100 @OxfordMedSci women to take part in a project showcasing diversity of roles they now hold.
Re-visit the #100WomenOfOxfordMedSci profiles here: medsci.ox.ac.uk/100-women-of… #IWD2022
ALT Faces of the 100 women who took part in the project
Knight Genetics retweeted
NEWS: A multi-disciplinary team, including biologists, clinicians, nurses, mathematicians and physicists from across @OxfordMedSci, @mplsoxford and @OUHospitals, publish a blood atlas defining hallmarks of #COVID19 disease severity. #COMBAT @OxImmuno
medsci.ox.ac.uk/news/covid-1…
Knight Genetics retweeted
New Resource in the latest issue! A blood atlas of #COVID19 defines hallmarks of disease severity and specificity
For all @CellPressNews #coronavirus research visit cell.com/2019-nCOV
#SARSCoV2
@KnightGenetics @NDMOxford @OxfordMedSci @DrCarlaCohen
bit.ly/3pAmB8R
Knight Genetics retweeted
For those interested in high-resolution targeted Chromosome Conformation Capture (3C), we have published a comprehensive step-by-step protocol of the Capture-C approaches: nature.com/articles/s41596-0…
Knight Genetics retweeted
We are delighted that @mkveerpn will be joining us on 7th February to give his talk, 'The Global COVID-19 Host Genetics Initiative: Mapping of the Host Genetic Architecture of COVID-19 while Improving Diversity in Genetics'.
Register here to attend: cpm.well.ox.ac.uk/event/kuma…
Knight Genetics retweeted
A stunning day to study in Oxford 📚😍
📷 | @aruggeri_eu
ALT A view from inside Brasenose College which shows Radcliffe Camera as well as a pride flag.
Knight Genetics retweeted
Paraneoplastic neurological syndromes
Binks & @ANG_Oxford team describe how clinical and paraclinical features vary according to the rapidly expanding list of antibodies. Antibody-syndrome-tumour triad correlation is key to determining clinical relevance
bit.ly/3u6QDUL
Knight Genetics retweeted
Year 12 learners📣
Applications for the @OxfordUNIQ programme CLOSE SOON❗
Don’t miss the chance to find out more about studying at Oxford, explore different subjects and meet current Oxford students🎓
Applications close 7 Feb ‘22
Find out more👇
uniq.ox.ac.uk/
Knight Genetics retweeted
NEW PUBLICATION 📖: ‘A Blood Atlas of COVID-19 Defines Hallmarks of Disease Severity and Specificity’ Highlights include Shared and specific immune signatures of COVID-19, influenza and all cause sepsis. Read it here: cell.com/cell/fulltext/S0092… @UniofOxford #Covid19 #Immunology
Knight Genetics retweeted
Please check out our new paper @CellPressNews. Remember to read the supplement where the authors are listed! cell.com/cell/fulltext/S0092…
Knight Genetics retweeted
Hiring a Project Manager for our new, exciting Oxford-GSK Institute for Molecular and Computational Medicine (IMCM.): my.corehr.com/pls/uoxrecruit…
It will be fun, and fundamentaly change how we develop medicines for neurodegenerative diseases.
Knight Genetics retweeted
The University's Black Academic Futures programme offers fully-funded scholarships for 2022-23 PhD or master's study.
Apply now for graduate courses using the 21 January deadline: ox.ac.uk/admissions/graduate…
Knight Genetics retweeted
Students who have been on UNIQ are more likely to make successful applications to Oxford. Don’t let your students miss out on a chance. UNIQ applications are open NOW. uniq.ox.ac.uk #UNIQ2022
ALT Two female students looking at a statue in a museum. The text around the image reads, 'UNIQ gives you the chance to explore subjects that interest you alongside Oxford academics. Apply now'. The text below the image reads, 'UNIQ applications are now open. Find out more at uniq.ox.ac.uk'. The UNIQ logo and University of Oxford logo are also present.
Knight Genetics retweeted
🎉 Excited to start 2022 by sharing our new recommendations for clinical interpretation of non-coding region variants:
medrxiv.org/content/10.1101/…
We are posting as a pre-print before journal submission to get your feedback - so please, get interpreting and share your thoughts! 1/9
