Neuroscience lab investigating the molecular mechanisms of memory and how these mechanisms are disrupted in a variety of cognitive disorders.
New York University
Joined July 2019
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Check out @prerana123's exciting paper on sex-specific differences in anxiety-like behaviors in TSC. Amazing amount of work using multiple approaches. Many thanks to all of our collaborators!
Thrilled to share our new work on the neural mechanisms underlying pathological anxiety in Tuberous Sclerosis complex. Great teamwork from @neuro_living, @Lawdex01, @RodrigoTrianaD2, @ksanagustinr, @Mauricio_Neuro +others in @ShresthaLab & @KlannLab. biorxiv.org/content/10.1101/… (1/n)
So happy for @Mauricio_Neuro, whose paper was published over the weekend. He shows how eIF2alpha becomes dephosphorylated in response to neuronal stimulation, answering a long-standing question in the field. cell.com/cell-reports/fullte…. Congratulations Mauricio!
Big week for @Muhaned711 and the lab. On Monday, his first, first author paper was published in PNAS. Today, he gave an outstanding presentation and successfully defended his Ph.D. thesis. Muhaned rocks - we are all proud to have had the opportunity to do neuroscience with him!
Excited to share @Muhaned711's now published work describing the impact of epilepsy- and ASD-associated mutations in EEF1A2 on de novo translation, elongation, tRNA-binding, and actin bundling. Congratulations Muhaned! pnas.org/doi/10.1073/pnas.23…
Delighted to share @DrJessicaAlapin's exciting work on an optogenetic tool that can be used to block eIF4E-dependent translation in specific cell types in the brain. Many thanks to all former/current lab members for their help in pushing this through! doi.org/10.1101/2023.08.30.5…
Thrilled to share @fran_longo17's latest work describing cell type-specific disruption of striatal circuitry in FXS. Many thanks to our collaborators in the labs of @CarterAG, @BagniLab, & @NicTritsch - sometimes it takes a village! sciencedirect.com/science/ar…
Really excited to share @Mauricio_Neuro's latest work, where he describes a novel mechanism for eIF2alpha dephosphorylation in response to plasticity-inducing stimulation, answering a long-standing question in the field of neuronal translation. Congrats! biorxiv.org/content/10.1101/…
Klann Lab retweeted
Two open postdoc positions at @BagniLab @DNF_neuro! We are seeking for motivated candidates to investigate the mechanisms underlying neurodevelopmental deficits using🪰and 🐭. #postdoc #neuroscience #DNF
Send CV, Cover letter and 3 referees by August 1st, 2023 (see ad).
Excited to share @Muhaned711's work, where he describes how three separate ASD- and epilepsy-associated mutations in the gene encoding eEF1A2 alter translation elongation, neuronal morphology, tRNA binding, and actin bundling. biorxiv.org/content/10.1101/…
Happy to share @fran_longo17's work describing how cell type-specific changes in striatal MSNs drive repetitive behaviors in FXS mice. Many thanks to @CarterAG, @NicTritsch, & @BagniClaudia labs for sharing their expertise! biorxiv.org/content/10.1101/…
Klann Lab retweeted
Check out our paper on the optical control of translation with a puromycin switch - in neurons! A collaboration with @tongil_ko @KlannLab @mo_hannes pubs.acs.org/doi/10.1021/jac… #ribosome #photopharmacology #translation #puromycin
Klann Lab retweeted
Thrilled to share our review on the modulation of emotional and social behaviors by oxytocin
signaling in limbic network!! It was great fun working on this together with @RodrigoTrianaD2, Sayali Ranade, Jahel Guardado, @LeDouxScience and @klannlab. frontiersin.org/articles/10.…
Klann Lab retweeted
Stephen T. Warren Memorial Symposium Nov 29-30, 2022 @EmoryMedicine -- honoring giant in #fragilex + repeat disorders field! More speakers announced including @nelsondl @EricTWang @KlannLab @SusanLAckerman1 Registration link: surveymonkey.com/r/N7F65YR
Today at @NYU_CNS, @erin_schuman gave the Valle Foundation Visiting Professor Lecture, where she discussed her groundbreaking work on local neuronal translation. Erin's talk was amazing - we are very excited to host her for an entire month here in NYC!
The EMBO Workshop on RNA Localization and Local Translation held in Sant Feliu De Guixols, Spain concluded today. What a great meeting! Many thanks to @BassellLab, @ChaoLabFMI, Anne Ephrussi, and Geraldine Seydoux for organizing!
Congratulations to Harrison Evans, who was awarded a Research Fellowship from @alzassociation to fund his exciting work on translation dysregulation in neurodegenerative disease!
Yesterday I was thrilled and extremely grateful to find out that I had been awarded the @alzassociation
Research Fellowship. This funding will support my work within the @KlannLab exploring how impairments in protein synthesis contribute to various forms of dementia. #ENDALZ
Klann Lab retweeted
Excited to share our work on the optical control of translation and monitoring of newly synthesized proteins in neurons with a puromycin-based diazocine photoswitch. @DirkTrauner @KlannLab @Mauricio_Neuro @DrJessicaAlapin @mo_hannes @nyuchemistry @NYU_CNS
biorxiv.org/content/10.1101/…
Excited for former postdoc Magda Kalinowska, whose work was published online today! With help from @fran_longo17 & @Mauricio_Neuro, she found that deleting Fmr1 in PV neurons alters translation and causes selective ASD-related behaviors. doi.org/10.1186/s13229-022-0… #fragileXsyndrome
Klann Lab retweeted
We are excited to announce that Dr. Anders Nelson (@andersmnelson) will join the Center for Neural Science at NYU, with his lab opening in 2023!
andersmnelson.com/
