@KenLauLab
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Excited to share our latest work published in @Nature, by grad student @mirazul302, currently on the job market. We uncovered clonal dynamics relating normal to tumor cells using natural and synthetic genetic changes. #SingleCell #DevBio #CRISPR #CRC #HTAN nature.com/articles/s41586-0…
Ken Lau Lab retweeted
Location, location, location—in Inflammatory bowel disease (#IBD)
doi.org/10.1172/JCI201729
Paige N. Spencer @Paige_N_Spencer, Monica E. Brown @moni_e_brown, Ken S. Lau @KenLauLab & team @VUMChealth determine how chronic inflammatory disease can manifest in a region-specific fashion, providing a unique model of #Crohn’s disease that reveals #Chlamydia and genetic risk as a trigging combination for Crohn’s disease-like inflammation in the proximal colon.
The image shows the host-pathobiont interface in the inflamed murine proximal colon, where intracellular Chlamydia muridarum (MOMP; green) in epithelial cells induces goblet cell-specific expression of indoleamine 2,3-dioxygenase 1 (IDO1; magenta); nuclei (blue). Image credit: Monica Brown, Paige Spencer, and William Kim.
Why does Crohn’s disease affect different regions of the GI tract? @Paige_N_Spencer tackled this in our latest study (in press @jclinicalinvest), uncovering region-specific responses that drive inflammation in the PROXIMAL colon to a pathobiont. 🔬🧬 jci.org/articles/view/201729
Shoutouts to the collaborators and groups that made this project possible: @valdi001 @Wenhan_Zhu1 @jeremygoettel @Dr_LoriCoburn @moni_e_brown @VUBasicSciences @VanderbiltCDB
#inflammation #microbiome #Crohnsdisease #IBD
Happy Holidays to all! Hope we can overcome the challenges of the past year in the coming New Year! (courtesy of @w_janney)
ALT Happy Holidays to all! Hope we can overcome the challenges of the past year in the coming New Year!
Vanderbilt Symposium on AI, Spatial & Systems Biology 2025. Thank you all for coming out on the weekend! @VUBasicSciences. Key note: Dr. Jonathan Liu from Stanford on hybrid open top light sheet microscopy!
Ken Lau Lab retweeted
Excited to speak this weekend at the Vanderbilt Symposium on #AI, #Spatial & Systems Biology 2025—hosted by @KenLauLab and @tae_hwang at @VanderbiltU’s Center for Computational Systems Biology. 🌟A stellar speaker lineup!
Agenda: vanderbilt.edu/computational… Onsite full—join virtually
So glad to be spending a few days with @SKDevStemCell @SK_GGB @SickKidsNews to share great science and friendship! Beautiful Blue Mountain Venue.
Ken Lau Lab retweeted
Congratulations to @K_Harsim from @KenLauLab for winning the Poster Prize at the Beatson International Cancer Conference 2025!
Thanks to @MolOncology for sponsoring this prize
#BICC2025
Congratulations to @skotomorph for winning this year's Mentorship Excellence Award! Honored to have such an inspiring individual in our midst! @VUBasicSciences
Proud of @Paige_N_Spencer and @mirazul302 for completing their PhD journeys with me last week. The best is yet to come!
Thank you to Vlaams Instituut voor Biotechnologie (VIB) for inviting me to the conference on Immune Niches in Cancer & Inflammation in beautiful Bruges. Feels like walking into a Disney story. Incredible science!@cell #INCI25
Thank you Yonsei-Severance for hosting a wonderful conference : YONSEI HTAN SCL G1's Lab K-BioX global summit 6. Have great respect for Korean science and tech. @tae_hwang @IamLinghua @DrMingyaoLi
