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I am grateful and excited to share this work. MscK is a beautiful protein - working with it has been a joy. Congratulations to my supportive coauthors, mentors, and friends who made this possible @YuanLabWUSTL, Grigory Maksaev (WUSTL), Brock Summers (WUCCI), and @JAJFitzpatrick.
Excited to share our latest work on gating of a potassium-dependent mechanosensitive ion channel, MscK. Work led by an amazing graduate student @JonathanMount6 Congrats to all authors Greg, Brock, @JAJFitzpatrick. nature.com/articles/s41467-0…
Jonathan Mount retweeted
PhD supervisor: What's wrong with your data?
Mum: What's wrong with you?
Therapist: What's wrong with your life?
Predatory journals: Dear Eminent Professor,
Jonathan Mount retweeted
As tens of thousands across America protest the violence that ICE sows with impunity, federal agents shot and killed another person in Minneapolis today.
ICE terrorizes our cities. ICE puts us all in danger. Abolish ICE.
Jonathan Mount retweeted
First they came for the Immigrants.
And I wrote a memo.
Then they came for trans people.
And I wrote a memo.
Then they came for the comedians.
And I wrote a memo.
Then they came for me.
And there was no one to write a memo for me.
House Democratic leaders issue a joint statement calling on @BrendanCarrFCC to resign, labeling his actions a “corrupt abuse of power.”
Jonathan Mount retweeted
Fixed it:
--> last year, the U.S. sold more educational services to the rest of the world than it sold in natural gas and coal **combined**
--> every $1 of research funded by NIH generates $2.56 in economic activity
--> more than 1.1M foreign students come to the U.S. each year to study and they contributed over $43 billion to the U.S. economy in foreign currency balances
--> students who came to the U.S. to study founded 55% of America’s 582 start-up companies worth at least $1 billion
--> cutting health research in Texas will cause a loss of 3,698 jobs and cost the economy $856M
--> The University of Alabama is the largest employer in the state
--> shortage of trained occ/env docs set to cost CA $1B
RECEIPTS🧵
Jonathan Mount retweeted
Oh please. There’s a lot of room for improvement at the NIH, but its entire budget is less than 1% of total federal expenditures in 2024.
Replying to @MacFarlaneNews
VA is the prime target for job cuts under Project 2025. If you want to reduce the size of the federal government, the VA and NIH is where you start. Nothing else makes a dent.
Dear Ion Channel and Structural Biology friends - I'm moving over to Bluesky! I'll still be here from time to time but plan to be more active over there ([email protected]). Catch you on the flipside!
Jonathan Mount retweeted
Two of the most qualified women in the country ran for president against an unqualified, racist game show host who had a history of committing fraud and sexual abuse. And the country was basically split 50-50. That should tell us some things.
Jonathan Mount retweeted
If Billionaires like Jeff Bezos and Elon Musk don't want Kamala Harris to win, maybe she's actually good for people who aren't billionaires.
Jonathan Mount retweeted
Collaborative work of @slavicaPD, @Hashemyaser4, Jovanovic Lab and @DjuranovicLab - a new method to isolate ribosomes and translational material in minutes. We show multiple usage of our RAPPL method in biochemical and structural assays with ribosomes. Please be free to contact us for further instructions if needed. @IsraelF96135088 you'll like this one.
A rapid, facile, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies biorxiv.org/content/10.1101/…
Jonathan Mount retweeted
Wonderful news! Parafilm M rules!
Very well-deserved recognition after helping so many other #NobelPrize winners achieve their breakthroughs! Congratulations @ParafilmM
Jonathan Mount retweeted
Excellent thesis defense by Dr. Gao! Congratulations Jian, we are very proud of you! 🥳
Jonathan Mount retweeted
Conformational change in transitioning from the inactive UvrD1 monomer-DNA structure to the leading subunit of the activated UvrD1 dimer-DNA structure. biorxiv.org/cgi/content/shor…
Jonathan Mount retweeted
Congratulations to Drs. Irfan Lodhi, Jeffrey Millman, Maria Remedi, and Julie Silverstein on achieving full professorship in their careers! Learn about each of their journeys: bit.ly/3Xs4FyM. @JeffreyRMillman @LodhiLab @WUDeptMedicine
Jonathan Mount retweeted
Nature research paper: Signatures of magnetism control by flow of angular momentum go.nature.com/4e9sFfz
Jonathan Mount retweeted
Any sufficiently advanced research project is indistinguishable from a drunken walk.
Jonathan Mount retweeted
A huge shoutout to my 'partner in crime' @JonathanMount6 and the invaluable contributions of Jian Huang, @johncowgill11, Yongchang Chang, Kathleen Bickel, the @YuanLabSinai, and the Jianhan Chen lab at UMass. I’ve learned a lot from these amazing people!
The open state was certainly tricky to capture and revealed more than a few unexpected features! Happy to have played a role. Thanks and congratulations to @veburts @ChandaLab06 @YuanLabSinai @johncowgill11, Yongchang Chang, Jianhan Chen and Jian Huang, and Kathleen Bickel
Structures of channels in Open conformation are rare. Thrilled to share our latest manuscript..
Structural basis for hyperpolarization-dependent opening of human HCN1 channel disq.us/t/4p78xec




























