@JohnHelmann

Professor. Bacillus subtilis physiology and stress responses (metal homeostasis, redox stress, antibiotic resistance & cell envelope). EIC of Mol Microbiol.

 Cornell University, Ithaca, NY
Joined May 2014
  • Tweets1.3K
  • Following773
  • Followers2.7K
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John D. Helmann retweeted
The Pi Lab@hualiang2018
24 Nov 2024
Curious about organelle biogenesis in bacteria 🦠🔬Check out our review on bacterial organelles and their role in iron physiology @MolMicroEditors doi.org/10.1111/mmi.15330

Bacterial Organelles in Iron Physiology

A proposed model of iron trafficking during ferrosome formation.

onlinelibrary.wiley.com
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John D. Helmann retweeted
Sáenz Lab@LabSaenz
13 Nov 2024
🥳A tuneable minimal cell membrane reveals that two lipid species suffice for life: nature.com/articles/s41467-0…. We chemically minimized the membrane of the Minimal Cell...they survived, but with some interesting shapes, like this 'Death Star' phenotype @Ijustice555 @JCVenterInst
Sáenz Lab@LabSaenz
25 Oct 2023
🦠 Minimal Membranes for Minimal Cells 🦠! In our latest study, we introduce an approach to minimize and tune lipidome composition in mycoplasma and the Minimal Cell JCVI-Syn3A. tinyurl.com/53235uzt #Lipidtime @BCUBE_TUDresden @JCVenterInst @Ijustice555 @James_Saenz
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John D. Helmann retweeted
Paul Babitzke@BabitzkePaul
4 Nov 2024
I am pleased to announce that our paper describing the role of NusG-dependent RNA polymerase pausing on the function of 5 riboswitches is now published in NAR. academic.oup.com/nar/advance…

NusG-dependent RNA polymerase pausing is a common feature of riboswitch regulatory mechanisms

Abstract. Transcription by RNA polymerase is punctuated by transient pausing events. Pausing provides time for RNA folding and binding of regulatory factor

academic.oup.com
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John D. Helmann retweeted
Benjamin Ezraty@EzratyB
8 Oct 2024
A new study in PNAS explores the connection between methionines and copper, with a focus on CueO. A collaboration between @lcb_officiel and @BIP8_Marseille 🍾🍾 Methionine-rich domains emerge as facilitators of copper recruitment in detoxification systems pubmed.ncbi.nlm.nih.gov/3937…
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The evolution and functional significance of the programmed ribosomal frameshift in prfB biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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🧵 Exciting new findings on bacterial stress response regulation, driven by small proteins (≤50 amino acids). Big shoutout to the amazing team behind this work led by @vsangeev. Read the full study here: biorxiv.org/content/10.1101/…
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John D. Helmann retweeted
Jörg Stülke@JorgStulke
28 Aug 2024
Read the new story of @WarnekeRobert on coenzyme A biosynthesis in Bacillus subtilis and the identification of a novel metabolite, cysteinopantetheine! Excellent collaboration with @c_elfmann @IFeussner and teams! @mbiojournal @uniGoettingen #subtiwiki journals.asm.org/doi/10.1128…

Coenzyme A biosynthesis in Bacillus subtilis: discovery of a novel precursor metabolite for salvage...

Vitamins are essential components of the diet of animals and humans. Vitamins are thus important targets for biotechnological production. While efficient fermentation processes have been developed...

journals.asm.org
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John D. Helmann retweeted
Doerr Lab@DoerrLab
27 Aug 2024
Our new paper out in @PLOSPathogens today: dx.plos.org/10.1371/journal.… We find that resistance/tolerance to antimicrobial peptides is slightly more complex and dynamic than your "average" antibiotic resistance. Nice work by @AndyMurtha et al.!
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New in JB: Kochanowsky, Vedantam et al. show that Clostridioides difficile deploys a superoxide reductase to resist the effects of oxygen. journals.asm.org/doi/10.1128… @ASMicrobiology @JBacteriology
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Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS @NatureComms from @HamoenLeendert with @HenrikStrahl @KursadTurgay nature.com/articles/s41467-0…

Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS

Nature Communications - The bactericidal activity of several antibiotics partially relies on production of reactive oxygen species (ROS), which requires the Fenton reaction. Here, the authors show...

nature.com
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Very excited that this collaborative project is now published. This work was championed by Dr. Yu Tang @Tangyu0901 (Tongji University School of Medicine) and started during a visit to my lab. academic.oup.com/nar/article… 1/N

Transposition with Tn3-family elements occurs through interaction with the host β-sliding clamp...

Abstract. Tn3 family transposons are a widespread group of replicative transposons, notorious for contributing to the dissemination of antibiotic resistanc

academic.oup.com
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John D. Helmann retweeted
HarsheyLab@harsheylab
11 Aug 2024
onlinelibrary.wiley.com/doi/… @BlastMeetings @MolMicroEditors

Flagellar protein FliL: A many‐splendored thing

In all her splendor, Lakshmi, the Indian Goddess of Wealth, perfectly represents the multitasking flagellar protein FliL. The objects in each of her four hands are symbolic of the many FliL functio...

onlinelibrary.wiley.com
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John D. Helmann retweeted
Olivia Paxie@olivia_paxie
9 Aug 2024
I’ve felt more than lucky to be able to tour around the US! Thanks to @JohnHelmann and his whole lab for being so welcoming and talking some great science (and not science!) with me this week 🧬👩‍🔬
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Finally published! Check out the final version of our paper describing the discovery of methylolanthanin, a lanthanide metallophore secreted by methylotrophs! pnas.org/doi/epub/10.1073/pn…
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The long-awaited structure of Bacillus MntR bound to DNA! While structures of iron-sensing DtxR family members bound to DNA have been known for decades, the DNA complexes of manganese sensors have long eluded structure elucidation. Cryo-EM to the rescue!
John D. Helmann@JohnHelmann
1 Jul 2024
Excited to see this detailed view of MntR-oligomerization that is key for Mn-activated transcription in B. subtilis! Work led by Shivani Ahuja and Arthur Glasfeld. Structural basis for transcription activation through cooperative recruitment of MntR biorxiv.org/content/10.1101/…

Structural basis for transcription activation through cooperative recruitment of MntR

The manganese transport regulator (MntR) from B. subtilis is a dual regulatory protein that responds to heightened Mn2+ availability in the cell by both repressing the expression of uptake transpor...

biorxiv.org
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N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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John D. Helmann retweeted
Daniel Lopez@lopesrra
6 Jul 2024
A huge step in understanding the biological role of flotillin and membrane microdomains. Led by our very own Marta Ukleja 🇵🇱🙌🙌🙌 with the help of @CavaLab_MIMS, @mateus_lab and (twitterless) Ana Eulalio :-). @CaixaResearch funding. rdcu.be/dMWvC
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Excited to see this detailed view of MntR-oligomerization that is key for Mn-activated transcription in B. subtilis! Work led by Shivani Ahuja and Arthur Glasfeld. Structural basis for transcription activation through cooperative recruitment of MntR biorxiv.org/content/10.1101/…

Structural basis for transcription activation through cooperative recruitment of MntR

The manganese transport regulator (MntR) from B. subtilis is a dual regulatory protein that responds to heightened Mn2+ availability in the cell by both repressing the expression of uptake transpor...

biorxiv.org
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John D. Helmann retweeted
Eric Skaar@EricSkaar
27 Jun 2024
A family of DNA glycosylases in bacteria that repairs interstrand DNA crosslinks, protects against acid, and is involved in infection. New work from @DKunk and @YujuanCai in collaboration with @BFEichman @PNASNews pnas.org/doi/10.1073/pnas.24…
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