@DoerrLab

We study how bacteria build and maintain a healthy cell envelope and resist killing by antibiotics.

 Ithaca, NY
doerr.wicmb.cornell.edu/
Joined August 2017
  • Tweets298
  • Following635
  • Followers1.6K
65Media
Thrilled to share the first paper of my PhD @DoerrLab is live at PLOS Pathogens! journals.plos.org/plospathog…

Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of...

Author summary Bacteria can survive exposure to antibiotics by constantly repairing cellular damage induced by the drug. This “antibiotic tolerance” enables diverse bacteria to survive long enough to...

journals.plos.org
2
8
21
2,190
Baskin Lab researchers have uncovered the surprising role played by a “three-tailed” fat molecule in cellular survival during heart attack and stroke: protecting the cells against damage when oxygen runs out. news.cornell.edu/stories/202…

‘Three-tailed’ lipid helps cells survive during heart attack, stroke | Cornell Chronicle

Cornell researchers have uncovered the surprising role played by a “three-tailed” fat molecule in cellular survival during heart attack and stroke: protecting the cells against damage when oxygen...

news.cornell.edu
4
8
742
Research led by @weillinstitute postdoctoral fellow Megan Keller in @DoerrLab reveals how sugar-phosphate buildup disrupts cell wall synthesis, offering clues to fight drug resistance. news.cornell.edu/stories/202…

Cornell biologists expose bacteria’s hidden Achilles’ heel | Cornell Chronicle

Helping to combat the rising threat of antibiotic resistance, Cornell biologists have identified a surprising mechanism that weakens bacteria from within—an insight that could guide the next genera...

news.cornell.edu
3
4
357
We’re thrilled to announce our Weill Institute 2025 Emerging Scholars –– eight outstanding grad students & postdocs selected for their innovative research, from institutions across the US and Canada. We'll welcome them to Cornell’s campus Oct 13–14, 2025. bit.ly/45f5GwQ
3
9
3
21
8,163
Doerr Lab retweeted
mBio@mbiojournal
29 Jul 2025
Molecular mechanism revealed for bacterial sugar overload. doi.org/10.1128/mbio.01729-2… @MRKmicrobes @DoerrLab
12
27
2,029
Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea biorxiv.org/cgi/content/shor… #biorxiv_cellbio
36
16
117
138,171
📢 Attention antibiotic tolerance researchers! Our GIANT review of 50+ years' of clinical antibiotic tolerance data is now available online in Clinical Microbiology Reviews. Check it out here: journals.asm.org/eprint/UUSI… @ASMicrobiology @Hobbs_Lab_Micro @DeventerAshley @microclaire
3
100
3
349
25,525
Congratulations to Dr. Manuela Alvarado Obando for an amazing PhD defense seminar! Felicidades, and on to more greatness! @CornellMicrobio @ManuelaAlv95 dx.plos.org/10.1371/journal.… If you are looking for an exceptional postdoc (and are in the greater NYC area), reach out to her!
3
7
45
2,273
Latest preprint from our lab led by grad student @cassidyprints and her undergrad mentee @IsabellaNLin. She examines conservation and features of the programmed ribosomal frameshift in prfB. Presented by Cassidy at #GRC stress! biorxiv.org/content/10.1101/…

The evolution and functional significance of the programmed ribosomal frameshift in prfB

Release Factor 2 (RF2) is one of two peptide release factors that terminate translation in bacteria. In Escherichia coli , the gene encoding RF2, prfB , contains an in-frame premature RF2-specific...

biorxiv.org
5
13
1
42
4,925
What a phenomenal seminar today at @CornellPathogen by @Hatzios_Lab — a tour de force of using chemical proteomics to discover new mechanisms of redox signaling in gut infection!🤩🤩🤩
3
31
3,510
Out now in @NatureComms: Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode @CavaLab_MIMS @FelipecavaM @DoerrLab nature.com/articles/s41467-0…

Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode

Nature Communications - The regulatory mechanisms governing peptidoglycan-degrading autolysins remain poorly understood. In this work, Alvarez et al. show that lytic transglycosylase activity is...

nature.com
18
56
11,245
Our new paper out in @PLOSPathogens today: dx.plos.org/10.1371/journal.… We find that resistance/tolerance to antimicrobial peptides is slightly more complex and dynamic than your "average" antibiotic resistance. Nice work by @AndyMurtha et al.!
10
44
2,731
We demonstrated a lowcost device that can detect deadly bacteria in drinking water. It shows, once again, that worldclass research can flourish in Nepal, despite limited resources. Here is news release by @OpticaWorldwide highlighting the important result. optica.org/about/newsroom/ne…
2
6
369
Announcing the 2025 Bacterial and Archaeal Cell Biology and Development @GordonConf. We have amazing speakers and discussion leaders confirmed and look forward to (again) having our minds blown by all the remarkable science. Applications will start being accepted in the fall.
2
35
4
98
16,864
And that concludes our workshop in Nepal! Successfully cloned NDM carbapenemases? Check! Isolated bacteria that can eat styrofoam and motor oil from Bagmati River AND fluoresce under UV? Check! @rajbhandari_33 @karmamonima @guavadk @utsavRIBB @AnkitSh03786959
5
22
961
Excited to kick off a bacterial genetics workshop at RIBB Kathmandu! We will be cloning some clinical NDM enzymes. ⁦@rajbhandari_33⁩ ⁦@karmamonima⁩ ⁦@guavadk⁩ ⁦@utsavRIBB⁩ @ankitsh03786959 ⁦@drakarki⁩
3
2
21
1,691
I asked AI to draw an image of the bacterial OM. This is what it came up with. My lab better pivot to the new hot field of outer pemmoccan homeostasis! And how is that one otter equally distributed among daughter cells? Lots of cool open questions!
1
13
1,609
Huge Congratulations to Dr. Megan Renée Keller @MRKmicrobes for successfully and epically defending her PhD today! #proudPI @Cornell_BBS
2
3
2
38
2,512
What an honor for @cassidyprints and @CornellMicrobio to host Dr. @Nancy_Craig777 for our distinguished Portraits of a Microbiologist series. Thanks for returning to Wing Hall for such a moving and inspiring visit!
2
8
36
2,951
⁦@FeagaHeather⁩ taking a picture of Portrait of a scientist organizer ⁦@cassidyprints⁩ and recipient Nancy Craig today! ⁦@CornellMicrobio⁩ ⁦@JoePetersLab⁩
1
4
22
1,250
Load more