ALT Single-cell genomics applied to developmental biology was hailed by Science as its “Breakthrough of the Year” in 2018. After the first single-cell transcriptome was published in 2009, the following decade saw biomedical science take a breathtaking leap into this field. We have seen the progression of single-cell genomics from niche to mainstream, from fad to necessity. But the journey from discovery to increased biological understanding is not smooth, nor is it complete. A challenge to convert the promise of single-cell genomics into tangible human health outcomes has been made. Our speakers have answered this call by investigating basic cellular biology, developmental biology, and clinical disease, by innovating new hardware and wet-lab solutions, and by developing new computational methods to analyse high-dimensional data. The single-cell genomics field has been defined by a spirit of openness and enthusiasm. Please help maintain this spirit by registering for our symposium