@JasonErnstLab

A computational biology lab at UCLA

 Los Angeles, CA
ernstlab.biolchem.ucla.edu/
Joined June 2019
  • Tweets103
  • Following1
  • Followers213
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Jason Ernst Lab retweeted
UCLA Biological Chemistry@BC_UCLASep 9
🔔 We are hiring! 🔔 We are looking for great colleagues doing curiosity driven research at the molecular level across broad areas of science. Please consider applying and spread the word! recruit.apo.ucla.edu/JPF1130…

Open Rank Faculty Position

University of California, Los Angeles is hiring. Apply now!

recruit.apo.ucla.edu
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Jason Ernst Lab retweeted
Chongyuan Luo@chongyuanluoJul 29
The peer-reviewed version of map3C, a tool developed by Joseph Galasso (co-advised by @jernst98) to more accurately map snm3C-seq data and enable robust 3D conformation modeling, has been published in OUP Bioinformatics. doi.org/10.1093/bioinformati…
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Jason Ernst Lab retweeted
Jason Ernst@jernst98Mar 25
I am a guest editor with Martha Bulyk and Katie Pollard of a Genome Biology special collection on "Prioritizing non-coding variants" Link for more information: link.springer.com/collection… Submission deadline: November 25, 2026.
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Learning a pairwise epigenomic and transcription factor binding association score across the human genome academic.oup.com/bioinformat…

Learning a pairwise epigenomic and transcription factor binding association score across the human...

AbstractMotivation. Identifying pairwise associations between genomic loci is an important challenge for which large and diverse collections of epigenomic

academic.oup.com
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Jason Ernst Lab retweeted
bioRxiv Genomics@biorxiv_genomicFeb 3
MissenseHMM: state-based annotations for missense variants through joint modeling of pathogenicity scores biorxiv.org/content/10.64898… #biorxiv_genomic
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Jason Ernst Lab retweeted
Chongyuan Luo@chongyuanluoJan 30
We are excited to release a single-cell and spatial 3D epigenomic atlas of developing human basal ganglia and inhibitory neurons, part of our BICAN effort in collaboration with @lab_paredes @jernst98 @emukamel @CEpigenomics @bpasaniuc biorxiv.org/content/10.64898…
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Thanks to @ferhatay and Aly Khan, we’re excited to announce a new chapter for RECOMB-RSG 2026. After years with ISCB/DREAM, we are transitioning to an official RECOMB satellite meeting (May 25 in Thessaloniki). recomb-rsg.github.io
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Jason Ernst Lab retweeted
Chongyuan Luo@chongyuanluo15 Oct 2025
We like to introduce map3C, developed by Joseph Galasso, that drastically improves the mapping and contact calling performance of snm3C-seq and now enables accurate 3D genome modeling. map3C was developed in collaboration with @jernst98 and Frank Alber biorxiv.org/content/10.1101/…
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📣New from Li et al! 📄Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia 👉bit.ly/4lWks1M
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GECSI: Large-scale chromatin state imputation from gene expression biorxiv.org/content/10.1101/… #biorxiv_bioinfo

GECSI: Large-scale chromatin state imputation from gene expression

Compendiums of chromatin state annotations based on integrating maps of multiple epigenetic marks such as from ChromHMM have become a powerful resource. While these compendiums have coverage of many...

biorxiv.org
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Genome-wide identification and analysis of recurring patterns of epigenetic variation across individuals: Communications Biology, Published online: 07 June 2025; doi:10.1038/s42003-025-08179-5Recurring genome-wide patterns of epigenetic mark variation… nature.com/articles/s42003-0…
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A new paper: "Genome-wide identification and analysis of recurring patterns of epigenetic variation across individuals" led by Jennifer Zou and @eamaciejewski is now published. nature.com/articles/s42003-0…

Genome-wide identification and analysis of recurring patterns of epigenetic variation across...

Communications Biology - Recurring genome-wide patterns of epigenetic mark variation across individuals learned through computational modeling relate to external measures of molecular variation and...

nature.com
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A new paper: "Identifying associations of de novo noncoding variants with autism through integration of gene expression, sequence, and sex information" led by Luke Li is now published genomebiology.biomedcentral.…

Identifying associations of de novo noncoding variants with autism through integration of gene...

Genome Biology - Whole-genome sequencing (WGS) data has facilitated genome-wide identification of rare noncoding variants. However, elucidating these variants’ associations with complex...

link.springer.com
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Will comparative biology crack the epigenetic code to longevity? New imputed DNA methylation dataset covers 59 tissues from 348 mammals including long living species such as bowhead whale (211 years), bats, and the naked mole rat. Which tissue holds the key to longevity? Which genes, CpGs, and genomic regions? Cutting-edge imputation applied to data from the Mammalian Methylation Consortium. Emily Maciejewski, Jason Ernst (2025) CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species. Genome Biology. pmc.ncbi.nlm.nih.gov/article… @JasonErnstLab @eamaciejewski #epigenetics #compbio #longevity

CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across...

The large-scale application of the mammalian methylation array has substantially expanded the availability of DNA methylation data in mammalian species. However, this data captures only a small...

pmc.ncbi.nlm.nih.gov
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A new paper "CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species" led by @eamaciejewski building on our lab's mammalian methylation array collaboration with @prof_horvath is now published genomebiology.biomedcentral.…

CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across...

Genome Biology - The large-scale application of the mammalian methylation array has substantially expanded the availability of DNA methylation data in mammalian species. However, this data captures...

link.springer.com
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A new paper "ChromActivity: integrative epigenomic and functional characterization assay based annotation of regulatory activity across diverse human cell types" led by @tevzilla is now published. genomebiology.biomedcentral.…

ChromActivity: integrative epigenomic and functional characterization assay based annotation of...

Genome Biology - We introduce ChromActivity, a computational framework for predicting and annotating regulatory activity across the genome through integration of multiple epigenomic maps and...

link.springer.com
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Perspective on recent developments and challenges in regulatory and systems genomics academic.oup.com/bioinformat… is out, amazing to think about this with @JuliaZeitlinger, @ferhatay, @mahonylab, @AMathelier, @AleMedinaRivera, @jernst98!

Perspective on recent developments and challenges in regulatory and systems genomics

Abstract. Summary: Predicting how genetic variation affects phenotypic outcomes at the organismal, cellular, and molecular levels requires deciphering the

academic.oup.com
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Here is a press release by ⁦@UCLAHealth⁩ that nicely summarizes the key findings from our paper published today ⁦@CellCellPress⁩. uclahealth.org/news/release/…

Mystery solved: New study reveals how DNA repair genes play a major role in Huntington's disease

uclahealth.org
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Happy to share our new paper published today @CellCellPress. Thanks to all our coauthors from @dgsomucla, @UCLASemel, and CHDI. Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice: Cell cell.com/cell/fulltext/S0092…

Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective...

Genes encoding distinct mismatch-repair complexes (i.e., Msh3 and Pms1) set a fast CAG-repeat expansion rate in vulnerable neurons to drive selective and progressive striatal and cortical pathogene...

cell.com
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Learning a Pairwise Epigenomic and Transcription Factor Binding Association Score Across the Human Genome biorxiv.org/cgi/content/shor… #biorxiv_bioinfo
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