We lost a true pioneer in the field of neuroscience and neuropharmacology, Dr. Floyd Bloom. Words can hardly capture the enormity of his contributions. His work was essential to our understanding of how neurotransmission works and how it influences mental disorders. Floyd’s influence extended far beyond his own research. He was a mentor extraordinaire, guiding the careers of numerous leaders in the field. The entire Salk and Scripps’s crew, including myself would not exist without him. I remember vividly how he edited my first paper in the addiction field, I was so intimidated at first but he was so kind, curious, and collegial it changed my mind about what a leader should be like. His former crew, Maury and Elena, were pivotal in the early days of setting up my own lab. Sigh Rest in peace, Floyd.