@JamieLMars

Principal Scientist in R&D at Solid Biosciences. White mountain hiking and cross-country skiing enthusiast. My views are my own and do not represent my employer

 Cambridge, MA
Joined June 2015
  • Tweets59
  • Following349
  • Followers201
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World Duchenne Awareness Day nationaltoday.com/world-duch… via @natltoday

World Duchenne Awareness Day — September 7, 2027 | National Today

World Duchenne Awareness Day on September 7 unites global efforts to highlight Duchenne and Becker Muscular Dystrophy. Learn about this genetic condition and how to support research and affected...

nationaltoday.com
Jamie Marshall retweeted
Greka Lab@GrekaLab30 Mar 2022
🎉 Greka lab paper alert! Our team is excited to share a new story published in @iScience_CP led by @JamieLMars describing the use of Slide-seqV2 to identify disease-specific cell neighborhoods in human and mouse kidneys. cell.com/iscience/fulltext/S…
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Fei Chen Lab@insitubiology20 Jan 2022
Interested in spatial transcriptomics analyses but don't know where to get started? Check out this very practical walk-through for analyzing Slide-seqV2 data of kidney tissue by our collaborators Teia Noel, @qbw_128, @AnnaGreka, and @JamieLMars! frontiersin.org/articles/10.…

Frontiers | Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney...

Spatial transcriptomic technologies capture genome-wide readouts across biological tissue space. Moreover, recent advances in this technology, including Slid...

frontiersin.org
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Jamie Marshall retweeted
Fei Chen Lab@insitubiology30 Dec 2021
Hello, Twitter! We're so grateful that 2021 was filled with exciting science and lab fun! For our inaugural tweet, we want to appreciate our lab members and collaborators by sharing some of their amazing work from the past 12 months Presenting the 2021 Chen Lab Year in Review:
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Haiqi Chen@haiqi_chen20 Dec 2021
Excited to launch the Reproductive Genomics Laboratory @UTSWNews. Grateful for the support from folks @insitubiology & collaborators. We are recruiting at all levels - pls see website for details. RT appreciated! haiqichenlab.github.io/

The Haiqi Chen Lab @ UTSW

Website for the Haiqi Chen Lab at the Cecil H. and Ida Green Center for Reproductive Biology Sciences, UTSW

haiqichenlab.github.io
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Jamie Marshall retweeted
zack chiang
@z_chiang15 Dec 2021
Just released @Nature: slide-DNA-seq, our new method for spatial DNA sequencing in tissues 🧬 Excited to add a genetic dimension to the rapidly expanding spatial toolbox with the tech dev superteam of Tongtong Zhao, @JD_Buenrostro & @insitubiology (1/6) nature.com/articles/s41586-0…
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Jamie Marshall retweeted
Haiqi Chen@haiqi_chen2 Nov 2021
Excited to share our work published today @CellReports on dissecting spermatogenesis using spatial transcriptomics. cell.com/cell-reports/fullte…

Dissecting mammalian spermatogenesis using spatial transcriptomics

Chen et al. generate a spatial transcriptome atlas of the mammalian testis at near-single-cell resolution that recapitulates spermatogenesis by accurately localizing testicular cell types and...

cell.com
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Thrilled to share the Kidney Slide-seq pre-print biorxiv.org/content/10.1101/…. HUGE thanks to the amazing kidney slide-seq team Teia Noel, @qbw_128, and @haiqi_chen. Thanks to Evan Murray for the Slide-seq arrays, @SilvanaBazua, and @AnnaGreka, Fei Chen, and @macosko for mentorship!

High Resolution Slide-seqV2 Spatial Transcriptomics Enables Discovery of Disease-Specific Cell...

High resolution spatial transcriptomics is a transformative technology that enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease...

biorxiv.org
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Thanks to @cziscience and @BroadIgnite for funding this work! @broadinstitute @GrekaLab
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Jamie Marshall retweeted
Anna Greka@AnnaGreka30 Jul 2019
Replying to @biohub @cziscience
Nice work @JamieLMars @broadinstitute and congrats to all the kidney teams! @HumphreysLab and Andy McMahon, and @hoheyn and Joshua Levin #HumanCellAtlas #kidneycellatlas
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Slide-seq technique generates high-resolution maps of cellular relationships in tissues, without the need for a microscope broadinstitute.org/news/new-…
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Irina Armean, PhD@imarmean28 Feb 2019
Great to see this work out!! Deep curated genomic, phenotypic data with functional validation of LRRK2 loss-of-function variants in #gnomAD and @23andMe data supporting LRRK2 inhibition as a safe therapy for LRRK2 gain-of-function mediated #Parkinson disease
Nicky Whiffin@nickywhiffin28 Feb 2019
Introducing the next gnomAD pre-print - in collaboration with @23andMeResearch we use highly curated genomic and phenotypic data from >4 million individuals to characterise the effects of life-long LRRK2 reduction in 1,358 loss-of-function carriers: biorxiv.org/content/10.1101/… 1/5

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic...

Human genetic variants causing loss-of-function (LoF) of protein-coding genes provide natural in vivo models of gene inactivation, which are powerful indicators of gene function and the potential...

biorxiv.org
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“Fei Chen, an electrical engineer by training, is building better microscopy technologies at his lab @broadinstitute.” Forbes #30Under30 fal.cn/S1.b
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Jamie Marshall retweeted
Anna Greka@AnnaGreka15 Feb 2018
Announcing Kidney-NExT4! Join us to hear from leaders in academia, industry, the FDA and patient advocacy on “Inventing the future of kidney therapeutics” broadinstitute.org/kidney-ne…

Fourth Annual Kidney-NExT Symposium: Inventing the future of kidney therapeutics

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broadinstitute.org
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gnomAD version 2.0.2, w better filtering, now available: gnomad.broadinstitute.org/ but note that ~final version 2.1 is coming in a few weeks.
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Thanks to my brilliant lab and amazing collaborators for making this work possible! xitter.cf/GeneticsSociety/status…
ASHG@GeneticsSociety14 Jul 2017
Congrats to @dgmacarthur, recipient of ASHG's first-ever Early Career Award! bit.ly/2t6Pezw #ExAC #gnomAD #genomics @broadinstitute
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Jamie Marshall retweeted
Cell@CellCellPress29 Jun 2017
What does a metabolic transporter have to do with #type2diabetes? #genetics youtu.be/U-xUjDAIycI @broadinstitute
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Video describing our effort to understand how #type2diabetes genetic variation at #SLC16A11 alters #T2D risk. @EitanHoch @broadinstitute xitter.cf/CellCellPress/status/8…
Cell@CellCellPress29 Jun 2017
What does a metabolic transporter have to do with #type2diabetes? #genetics youtu.be/U-xUjDAIycI @broadinstitute
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Steve Hyman on staff scientists - IMO expanding these roles is key path towards sustainable scientific careers. nature.com/news/biology-need…
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