@JJMilnerLab

Assistant Professor @UNC_Lineberger. T cell differentiation during infection & cancer.

 Chapel Hill, NC
unclineberger.org/milnerlab/
Joined January 2018
  • Tweets113
  • Following449
  • Followers410
Justin Milner retweeted
Alec Plotkin@alecplot
Mar 3
🕰️🚆🦠 Excited to share our new preprint: “Optimal transport fate mapping resolves T cell differentiation dynamics across tissues”! We use OT to infer realistic CD8 T cell differentiation and migration trajectories from scRNA-seq timecourses. biorxiv.org/content/10.64898… 1/
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Justin Milner retweeted
Alec Plotkin@alecplot
Mar 3
Huge thanks to my my mentors Natalie Stanley (@natstann, @comp_cy) & Justin Milner (@JJMilnerLab) and to my co-authors Genevieve Mullins, Will Green (@greenwilliamd), Huitong Shi, Haidong Yi, and Kay Chung (@HKayChung1) 🙏 10/
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Justin Milner retweeted
Waggoner Lab@LabWaggoner
Feb 28
Replying to @biorxivpreprint
@biorxivpreprint Optimal transport fate mapping resolves T cell differentiation dynamics across tissues biorxiv.org/content/10.64898… @JJMilnerLab @UNC_Lineberger @natstann
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Justin Milner retweeted
Waggoner Lab@LabWaggoner
Jan 18
Replying to @biorxivpreprint
@biorxivpreprint Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential @JJMilnerLab @Pratt__Brandon @UNC_Lineberger biorxiv.org/content/10.64898…
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Justin Milner retweeted
William Green@greenwilliamd
Jan 8
Amazing work by talented graduate student @Pratt__Brandon and team from the @JJMilnerLab @HKayChung1. Be sure to check it out how they devised a way to unlock the therapeutic potential of CD8 T cells!
bioRxiv Immunology@biorxiv_immuno
Jan 8
Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential biorxiv.org/content/10.64898… #biorxiv_immuno

Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential

Transcription factors (TFs) govern cell fate through coordinated gene-regulatory networks, yet the full potential of these networks to generate non-native, therapeutically advantageous cell states in...

biorxiv.org
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Justin Milner retweeted
Waggoner Lab@LabWaggoner
28 May 2025
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment @ImmunityCP @JJMilnerLab cell.com/immunity/fulltext/S…
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Excited to share the first of many works out of @JJMilnerLab. Be sure to check it out! Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment: Immunity cell.com/immunity/fulltext/S…
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Justin Milner retweeted
Mackay Lab@LMackayLab
12 Feb 2025
Thrilled we were part of #KSTCells25 @KeystoneSymposia in Vancouver 🇨🇦 and reunited with T cell friends & colleagues! Huge thanks to co-organizers @theLundLab, @Joshilabyale & @DelgoffeLab. We can’t wait for the next one!!
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Justin Milner retweeted
Jolene Ranek@JoleneRanek
30 Mar 2024
Delighted to share that our feature selection method for improving inference of cellular trajectories is out today in @NatureComms! Biggest thank you to @natstann @purvislab @WStallaert @JJMilnerLab + team 😊 Paper: rdcu.be/dCVZA . 🧵below.
Jolene Ranek@JoleneRanek
15 May 2023
Super excited to introduce DELVE (github.com/jranek/delve), an unsupervised feature selection method for improving inference of developmental or disease trajectories from noisy single-cell data: biorxiv.org/content/10.1101/… 😊(1/8)
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Justin Milner retweeted
Pylayeva-Gupta lab@YPGlab
16 Nov 2023
Thrilled to work with such talented and dedicated group of colleagues!! @derlabunc @YehlabUNC @bryant_kl @JJMilnerLab #adriennecox #ashwinsomasundaran #hjkim
UNC Pancreas Center@UNCPancreas
16 Nov 2023
It's World Pancreatic Cancer Day. To all affected by #PancreaticCancer, know that we are here with you 💜 Today and every day, our dedicated team @UNC_Lineberger works to find better ways to treat this devastating disease. #WPCD
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Justin Milner retweeted
CompCy Lab @ UNC@comp_cy
29 Sep 2023
Congratulations @alecplot for winning a best poster award at data science day for work predicting CD8 T-cell fates with @JJMilnerLab :) Truthfully, this a picture from last week, but is the same poster. Great job Alec.
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So pleased to announce that @JJMilnerLab has earned our 2023-24 @theNCI SPORE CEP Award for his project, "Molecular regulation of T cell activity in pancreatic ductal adenocarcinoma." Congratulations, Dr. Milner, we're excited to watch your progress this year! @UNC_Lineberger
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Happy to share that our story is out! @SciImmunology Our study demonstrates that sustained CD28 signaling, is required to maintain PD-1+ CD8 T cells during chronic antigen stimulation (1/) science.org/doi/10.1126/scii…

Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1+ PD-1+ CD8 T...

CD28 modulates the metabolism of PD-1+ CD8 T cells and is required to sustain responses during chronic antigen stimulation.

science.org
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Paper alert from the @GoldrathLab 🚨 (Link at the end). 🧵 (1/10) >>
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Here at UNC M&I, we're proud of our inspiring community of scientists who are changing the way we think about infections! We teamed with @kathaskfilms to provide an inside-look at how they do it. 📽️🔬 Full video: youtu.be/yHLFE7oTh7M and at med.unc.edu/microimm/ @UNC_SOM
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Replying to @ImmunoEditor @ScienceMagazine @CarolinaAlvesC5 @SciImmunology
Finally, @Pratt__Brandon & @JJMilnerLab put these two exciting papers in context with an outstanding @ScienceMagazine Perspective! bit.ly/Sci_adi3357
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Justin Milner retweeted
Bingfei Yu@BingfeiY
14 Dec 2022
Our work on ENTER is finally out @CellCellPress! Like📱that can 📷📞🎧, ENTER is a modular viral platform that unifies multiple applications: ⭐️Decode Ligand-Receptor interaction ⭐️Receptor-specific cargo delivery ⭐️Link receptor specificity with cell state at single cell
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Justin Milner retweeted
Pylayeva-Gupta lab@YPGlab
30 Sep 2022
So thankful for this honor! @UNC_Lineberger @UNCPancreas
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Our new preprint is out! This was a collaborative work between us and Dr. D’Imperio Lima at @icb_usp. Later today I will do a thread! T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections biorxiv.org/content/10.1101/…

T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung...

CD4+ T cells are key components of the immune response during lung infections and can mediate protection against tuberculosis (TB) or influenza. However, CD4+ T cells can also promote lung pathology...

biorxiv.org
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Justin Milner retweeted
Jolene Ranek@JoleneRanek
5 Sep 2022
Have you ever wondered if you could leverage RNA velocity data to better resolve biological trajectories or disease phenotypes? Delighted to share that our benchmarking study is out today in @GenomeBiology! Biggest thank you to @natstann @purvislab 😊 genomebiology.biomedcentral.…

Integrating temporal single-cell gene expression modalities for trajectory inference and disease...

Genome Biology - Current methods for analyzing single-cell datasets have relied primarily on static gene expression measurements to characterize the molecular state of individual cells. However,...

link.springer.com
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