Our lab studies the mechanisms of thymic T-cell tolerance. We develop innovative strategies to regenerate the thymic function and treat autoimmune diseases.

CIML Marseille France
Joined February 2022
Magali IRLA Lab retweeted
Replying to @IrlaLab
@IrlaLab and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in @ScienceTM. science.org/doi/10.1126/scit…
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New work connects #immunosenescence and the decline of the #thymus during aging with a drop in the ligand #RANKL—and shows RANKL treatment restores T cell production and rejuvenates immune responses in aged mice. @IrlaLab @JrmyCSantamaria @CIML_Immunology scim.ag/3ZAqihe
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Magali IRLA Lab retweeted
One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. science.org/doi/10.1126/scit… @ScienceTM
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Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk A recent study has found that vitamin D deficiency during childhood accelerates the aging of the thymus, an organ essential for developing a healthy immune system. The thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders, but when it ages prematurely due to a lack of vitamin D, it becomes less effective. This increases the risk of autoimmune diseases like type 1 diabetes, as the immune system may mistakenly attack healthy tissues. The research underscores the importance of adequate vitamin D intake, particularly during "vitamin D winter" when sunlight is insufficient for natural production. Ensuring children receive proper vitamin D supplementation during these months could help prevent autoimmune disorders.
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Review by Pala et al. highlights how novel cutting-edge technologies, incl. high-resolution imaging, single-cell omics & organoid cultures, have improved our understanding of human #thymus biology hubs.la/Q02TfwHP0 📘In our #Autoimmunity collection: hubs.la/Q02TfzFt0
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Magali IRLA Lab retweeted
New issue online! This beautiful cover depicts work from @maxim_artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog cell.com/immunity/issue?pii=…
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Magali IRLA Lab retweeted
LAI will host a seminar on Wednesday 16th of October at 11 a.m. in the Amphi 12, Bat B - Cyril Favard (IRIM) "Mechanics and Kinetics of HIV-1 assembly in living T cells: insights from single/few molecule dynamics"
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Magali IRLA Lab retweeted
Lymphotoxin is first inhibitory checkpoint of thymic Treg development that fine-tunes the Foxp3lo Treg precursor pathway by limiting IL-4 availability @IrlaLab @AlexiaBorelli nature.com/articles/s41467-0…
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Magali IRLA Lab retweeted
Join us for a free webinar on #ImmunityandAging. On #DayofImmunology, April 29th, we'll explore how time impacts Immune System function and its health effects. @IUSIS @EFIS @LintermanLab @BrodinPetter @Eberhardt_CS @EurJImmunol. Register now to secure your spot #AgingImmuneSystem
This year's International Day of Immunology will be Monday, April 29th! This year's theme is #ImmunityandAging! Register for our #DayofImmunology webinar: loom.ly/M63fa6w Learn about our social media contest for national and regional societies: loom.ly/yWRSIP0
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Magali IRLA Lab retweeted
📅Next @ImmunoPasteur seminar this Friday Magali Irla (@IrlaLab) from @CIML_Immunology Central thymic tolerance: regulatory mechanisms of Foxp3+ Treg developmental pathways Invited by Ana Cumano
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CENTURI 2024 #PhD call 📣 Among our projects: Videonanoscopy of the thymic immunological synapse during leukemogenesis ⏰Applications open until February 15 Check all our projects here! centuri-livingsystems.org/re… #interdisciplinarity #call #phd #job
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Magali IRLA Lab retweeted
Today we had the @CIML_Immunology scientific retreat in Marseille. Plenty of talks from students, post-docs and researchers, highlighting collaborative projects. Closing up with two debates: - Brain vs Gut: who is driving who? - Innate vs Adaptive: who is the best for memory?
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Magali IRLA Lab retweeted
Replying to @CellCellPress
For all things #thymus, next up in the Global Thymus Network meetings is Porto in May '24. Organized by (the twitterless) Nuno Alves, with @KruegerLab @TheAbramsonLab @taghon_t @IrlaLab @Vera22380790 thyme2024.pt/
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Magali IRLA Lab retweeted
Researchers Alexia Borelli, Cloé ZAMIT, and Magali Irla at @IrlaLab, @CIML_Immunology have developed a rapid co-culture assay enabling the evaluation of antigen-presentation ability of mTEC to CD4+ T cells in an antigen-specific context. (2/5)
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Magali IRLA Lab retweeted
Congrats to the Waterfield lab on this newly identified regulator of thymic tolerance.@AtUcsf @UCSF Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance | Science Immunology science.org/doi/10.1126/scii…
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Magali IRLA Lab retweeted
🚨We are recruiting ‼️🚨 We have one Post Doc and one RA position available in the lab! Closing date is the 6th of Nov. If interested, please check out the following links: Research Assistant - ucl.ac.uk/work-at-ucl/search… Research Fellow - ucl.ac.uk/work-at-ucl/search…
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