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🎉🎉🎉 Very happy to see my review out in @AnnualReviews on thymic T cell selection ! If you like T cells check it out !🎉🎉🎉 annualreviews.org/doi/abs/10…
Thrilled to share that our review in @ScienceAdvances is out!🧬We highlight how age-related thymic involution alters T-cell immunity and discuss therapeutic strategies to rejuvenate thymic function and promote healthier aging.
#immunology #Aging #thymus
science.org/doi/10.1126/scia…
Magali IRLA Lab retweeted
Replying to @IrlaLab
@IrlaLab and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in @ScienceTM. science.org/doi/10.1126/scit…
Magali IRLA Lab retweeted
New work connects #immunosenescence and the decline of the #thymus during aging with a drop in the ligand #RANKL—and shows RANKL treatment restores T cell production and rejuvenates immune responses in aged mice. @IrlaLab @JrmyCSantamaria @CIML_Immunology scim.ag/3ZAqihe
Thrilled to share our latest research in @ScienceTM ! We show that RANKL administration reverses age-dependent thymic involution and rejuvenates T cell immunity.
@CIML_Immunology
#aging #thymus #Tcells #Immunology #Involution #Rejuvenation
science.org/doi/10.1126/scit…
This increased production leads to peripheral T-cell renewal and improves T-cell-mediated anti-tumor and vaccine responses in aged mice.
Magali IRLA Lab retweeted
One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice.
science.org/doi/10.1126/scit… @ScienceTM
Magali IRLA Lab retweeted
I remember being blown away when @IrlaLab showed me these data @CIML_Immunology 🤯 - Exogenous RANKL substantially reverts thymic involution and improves T cell function in aged mice @ScienceTM
science.org/doi/10.1126/scit…
Magali IRLA Lab retweeted
A new study on @ScienceTM finds RANKL treatment can restore thymic function in aged mice and improve their T cell-mediated immune responses. #aging
@JrmyCSantamaria, Dr.Magali Irla @IrlaLab, Antoine Toubert of @univ_paris_cite, et al.
science.org/doi/10.1126/scit…
Congrats to @AlexiaBorelli for successfully defending her PhD thesis at @CIML_Immunology ! Her work has advanced our understanding of Foxp3+ Treg development and thymic recirculation, with 2 first-author papers in @NatureComms and Cell Mol Life Sci.
#Treg #Thymus #Immuno #CIML
Magali IRLA Lab retweeted
Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk
A recent study has found that vitamin D deficiency during childhood accelerates the aging of the thymus, an organ essential for developing a healthy immune system.
The thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders, but when it ages prematurely due to a lack of vitamin D, it becomes less effective.
This increases the risk of autoimmune diseases like type 1 diabetes, as the immune system may mistakenly attack healthy tissues.
The research underscores the importance of adequate vitamin D intake, particularly during "vitamin D winter" when sunlight is insufficient for natural production.
Ensuring children receive proper vitamin D supplementation during these months could help prevent autoimmune disorders.
Magali IRLA Lab retweeted
Sex-biased human thymic architecture guides T cell development through spatially defined niches: Developmental Cell cell.com/developmental-cell/…
Magali IRLA Lab retweeted
Review by Pala et al. highlights how novel cutting-edge technologies, incl. high-resolution imaging, single-cell omics & organoid cultures, have improved our understanding of human #thymus biology hubs.la/Q02TfwHP0
📘In our #Autoimmunity collection: hubs.la/Q02TfzFt0
Magali IRLA Lab retweeted
New issue online! This beautiful cover depicts work from @maxim_artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog cell.com/immunity/issue?pii=…


















