Ignatova Lab retweeted
The official website for the tRNA2024 Conference has been updated! You can now find the latest presentation schedules, session details, and notification to oral/poster presentation. Stay up to date and plan your presentation:
trna2024kanazawa.jp/
#tRNA2024
Ignatova Lab retweeted
That's what the pluripotent stem cell field has been waiting for. Own cells, reprogrammed to iPSCs; differentiated into insulin-producing cells, and translanted back into patient, effectively curing type-1 diabetes! One patient. One year. But a tremendous proof-of-concept.
Now online! Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient dlvr.it/TDnc6w
Ignatova Lab retweeted
At Tevard, we're devoted to improving the lives of people with severe genetic diseases like Duchenne muscular dystrophy (DMD). In honor of #WorldDuchenneAwarenessDay, learn more about DMD, and see how you can help raise awareness: bit.ly/3qh209B #WDAD24
Ignatova Lab retweeted
Preprint alert in collaboration with @fraser_lab !
We identify that deleting GidB, a 16S rRNA methyltransferase, acts as an "automatic braking system" for mistranslation!
Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA biorxiv.org/content/10.1101/…
Ignatova Lab retweeted
We're looking forward to the upcoming RNA Leaders USA Congress. Tevard CEO, Daniel Fisher, will give a presentation on our work to pioneer novel tRNA therapeutics and how our platform is enabling us to advance our pipeline. See the full agenda: bit.ly/3T9n295 #RNALeaders
Ignatova Lab retweeted
We report many proteins not predicted by the genetic code.
They are stable & abundant O( 10³ ) copies / cell.
Generative mechanisms include codon-anticodon mismatches & RNA modifications.
Their abundance depends on codon frequency & protein stability.
biorxiv.org/content/10.1101/…
Ignatova Lab retweeted
Single-cell proteomics helped answer a fundamental question in development:
The molecule mechanisms of symmetry breaking in early mammalian development.
A great collaboration with @MZG_Lab led by @aleks_petelski & @LIwamotoStohl.
You’re unable to view this Post because this account owner limits who can view their Posts. Learn more
Ignatova Lab retweeted
How to repurpose a #tRNA enzyme into a global stress sensor? Co-led by @CharlesBNader, Swati Gaikwad, Soheila Bahmanjah, w/ Alan Hinnebusch lab, in
@PNASNews, we describe how stress kinase Gcn2 adopts and molds Histidyl-tRNA synthetase as a regulatory hub. bit.ly/3YQbiMk
ALT https://www.pnas.org/doi/10.1073/pnas.2409628121
Ignatova Lab retweeted
I am very proud of the superstar postdoc @Yang_Haojun_01, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer.
nature.com/articles/s41586-0…
Ignatova Lab retweeted
Nature research paper: The ribosome lowers the entropic penalty of protein folding go.nature.com/4clH1rM
Ignatova Lab retweeted
The time to think and inquire are precious.
Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery.
nature.com/articles/d41586-0…
Ignatova Lab retweeted
How does one #tRNA-mimicking mascRNA from #MALAT1 get one CCA tail and is stable, while menRNA from #NEAT1 receives two marking it for decay? We uncover a #riboswitch-like mechanism where menRNA self-destructs by getting seconds.@IliasSkeparnias @NatureSMB go.nature.com/3WcOGmc
Ignatova Lab retweeted
Mistranslating tRNA variants have anticodon- and sex-specific impacts on Drosophila melanogaster biorxiv.org/content/10.1101/…
Ignatova Lab retweeted
Trying to engineer tRNA??? 🧬 We have a created a roadmap 🗺️ in our newest review. Check it out 👇🏼👇🏼👇🏼👇🏼
links.email.frontiersin.org/…
Ignatova Lab retweeted
Check out our latest publication and solution RNA structure of the 5′-terminal stem-loop of SARS-CoV-2, whose structure is sensitive to pH change, allowing the formation of a transient A+•C base pair!
Full text: doi.org/10.1093/nar/gkae477
#nmr #rna #structuralbiology
Ignatova Lab retweeted
We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. cell.com/cell/fulltext/S0092…
Ignatova Lab retweeted
We're excited to announce registration and abstract submission for tRNA2024 is now open!
You can get the early bird discount until July 16.
Please check our updated official homepage trna2024kanazawa.jp/.
Ignatova Lab retweeted
Agenda of #CRC1678: the fidelity of RNA and protein production declines with age and in disease. What are the systems-level consequences? How are the transcriptome and proteome affected? How are cells dealing with this stress? How are the different cellular processes interacting?
Ignatova Lab retweeted
#CRC1678 Fantastic news: our new CRC on systems-level consequences of fidelity changes in mRNA
and protein biosynthesis gets funded by @dfg_public!
This is an amazing team effort - 1000 thanks to everyone involved, the great reviewers and the DFG team! 🎉
Ignatova Lab retweeted
Another new publication is online in @NAR_Open 🥳
"Structure of an internal loop motif with three consecutive U•U mismatches from stem–loop 1 in the 3′-UTR of the SARS-CoV-2 genomic RNA"
Full text: doi.org/10.1093/nar/gkae349
#NMR #MD #SCov2 #structure
