@IgnatovaLab

A lab of #RNA lovers, obsessed with tRNA, translational control in protein biogenesis and disease. #translation #ribosome #mRNA #tRNA #SNP 🇺🇦

 Hamburg, Deutschland
chemie.uni-hamburg.de/bc/ignatova/
Joined June 2018
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  • Following661
  • Followers1.7K
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The official website for the tRNA2024 Conference has been updated! You can now find the latest presentation schedules, session details, and notification to oral/poster presentation. Stay up to date and plan your presentation: trna2024kanazawa.jp/ #tRNA2024
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Eran Meshorer@meshorer129 Sep 2024
That's what the pluripotent stem cell field has been waiting for. Own cells, reprogrammed to iPSCs; differentiated into insulin-producing cells, and translanted back into patient, effectively curing type-1 diabetes! One patient. One year. But a tremendous proof-of-concept.
Cell@CellCellPress28 Sep 2024
Now online! Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient dlvr.it/TDnc6w

Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior...

Chemically induced stem-cell-derived islets were transplanted beneath the abdominal anterior rectus sheath in one patient with type 1 diabetes, resulting in tolerable safety and promising restoration...

cell.com
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Highly recommended! PhD students apply
Suparna Sanyal@sanyal_suparna19 Sep 2024
We are looking for a highly motivated PhD student to explore molecular mechanisms of protein synthesis using fast kinetics and cryo-EM. Pls share the link or apply! uu.varbi.com/en/what:job/job…
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At Tevard, we're devoted to improving the lives of people with severe genetic diseases like Duchenne muscular dystrophy (DMD). In honor of #WorldDuchenneAwarenessDay, learn more about DMD, and see how you can help raise awareness: bit.ly/3qh209B #WDAD24
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Babak Javid@javid_lab29 Aug 2024
Preprint alert in collaboration with @fraser_lab ! We identify that deleting GidB, a 16S rRNA methyltransferase, acts as an "automatic braking system" for mistranslation! Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA biorxiv.org/content/10.1101/…

Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA

Despite redundant cellular pathways to minimize translational errors, errors in protein synthesis are common. Pathways and mechanisms to minimize errors are classified as pre-ribosomal or ribosomal....

biorxiv.org
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We're looking forward to the upcoming RNA Leaders USA Congress. Tevard CEO, Daniel Fisher, will give a presentation on our work to pioneer novel tRNA therapeutics and how our platform is enabling us to advance our pipeline. See the full agenda: bit.ly/3T9n295 #RNALeaders
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We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.1101/…

Alternate RNA decoding results in stable and abundant proteins in mammals

Amino acid substitutions may substantially alter protein stability and function, but the con-tribution of substitutions arising from alternate translation (deviations from the genetic code) is...

biorxiv.org
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Single-cell proteomics helped answer a fundamental question in development: The molecule mechanisms of symmetry breaking in early mammalian development. A great collaboration with @MZG_Lab led by @aleks_petelski & @LIwamotoStohl.
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How to repurpose a #tRNA enzyme into a global stress sensor? Co-led by @CharlesBNader, Swati Gaikwad, Soheila Bahmanjah, w/ Alan Hinnebusch lab, in @PNASNews, we describe how stress kinase Gcn2 adopts and molds Histidyl-tRNA synthetase as a regulatory hub. bit.ly/3YQbiMk
https://www.pnas.org/doi/10.1073/pnas.2409628121

ALT https://www.pnas.org/doi/10.1073/pnas.2409628121

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I am very proud of the superstar postdoc @Yang_Haojun_01, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer. nature.com/articles/s41586-0…
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nature
@Nature7 Aug 2024
Nature research paper: The ribosome lowers the entropic penalty of protein folding go.nature.com/4clH1rM
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Happy (t)RNA day! #RNADay Thank you to our first author baker Vale @Vblancoca - our terrific guest from @jptosar lab - who orchestrated the baking process.
Valentina Blanco@Vblancoca1 Aug 2024
Happy #RNADay! 🎉 Celebrating in Germany with the incredible scientists/bakers at @IgnatovaLab Check out our entry for the @RNASociety cake competition! 🍰🔬 We hope sharing our creation here is as welcomed as uploading a paper on @biorxivpreprint🤞 @jrRNAscientists
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The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. nature.com/articles/d41586-0…
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SMYD5 methylation of rpL40 links ribosomal output to gastric cancer | Nature nature.com/articles/s41586-0…
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How does one #tRNA-mimicking mascRNA from #MALAT1 get one CCA tail and is stable, while menRNA from #NEAT1 receives two marking it for decay? We uncover a #riboswitch-like mechanism where menRNA self-destructs by getting seconds.@IliasSkeparnias @NatureSMB go.nature.com/3WcOGmc

Structural basis of NEAT1 lncRNA maturation and menRNA instability

Nature Structural & Molecular Biology - This study reveals the mechanisms of NEAT1 lncRNA maturation and menRNA biogenesis and uncovers an RNA-centric, riboswitch-like mechanism where menRNA...

nature.com
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mRNA location and translation rate determine protein targeting to dual destinations - PubMed pubmed.ncbi.nlm.nih.gov/3750…

mRNA location and translation rate determine protein targeting to dual destinations - PubMed

Numerous proteins are targeted to two or multiple subcellular destinations where they exert distinct functional consequences. The balance between such differential targeting is thought to be determ...

pubmed.ncbi.nlm.nih.gov
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Ignatova Lab retweeted
Babak Javid@javid_lab2 Jul 2024
Mistranslating tRNA variants have anticodon- and sex-specific impacts on Drosophila melanogaster biorxiv.org/content/10.1101/…

Mistranslating tRNA variants have anticodon- and sex-specific impacts on Drosophila melanogaster

Transfer RNAs (tRNAs) are vital in determining the specificity of translation. Mutations in tRNA genes can result in the misincorporation of amino acids into nascent polypeptides in a process known...

biorxiv.org
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Discovery of antimicrobial peptides in the global microbiome with machine learning: Cell cell.com/cell/fulltext/S0092…

Discovery of antimicrobial peptides in the global microbiome with machine learning

A machine-learning-based approach predicts nearly one million new antibiotics from the global microbiome, with 79 out of 100 tested peptides being active in vitro and several showing efficacy...

cell.com
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Trying to engineer tRNA??? 🧬 We have a created a roadmap 🗺️ in our newest review. Check it out 👇🏼👇🏼👇🏼👇🏼 links.email.frontiersin.org/…
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