@IPuoti

Cellular and Proteomic Scientist at CeTPD University of Dundee| PhD| CRUK_BI and UofGlasgow alumna

 Dundee, Scotland
Joined July 2019
  • Tweets100
  • Following813
  • Followers318
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Thank you @BiochemSoc! We are honoured to receive this award. It highlights the importance of team science and partnership working.
Biochemical Society@BiochemSoc8 Apr 2025
Congratulations to ACBI PROTAC collaboration team, winners of the 2026 Industry and Academic Collaboration Award! Headed up by @alessiociulli, the trail-blazing collaboration with @Boehringer combines their world-class expertise in targeted protein degradation and drug discovery
The Biochemical Society 2026 Industry and Academic Collaboration Award ACBI (Alessio Ciulli- Boehringer Ingelheim) PROTAC Collaboration Team University of Dundee, UK

ALT The Biochemical Society 2026 Industry and Academic Collaboration Award ACBI (Alessio Ciulli- Boehringer Ingelheim) PROTAC Collaboration Team University of Dundee, UK

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Proteome integral solubility alteration via label‐free DIA approach (PISA‐DIA), game changer in drug target deconvolution analyticalsciencejournals.on… --- #proteomics #prot-paper
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Online now! #Perspective Next steps for targeted protein degradation by Mackenzie W. Krone and @CraigMCrews at @Yale @YaleChem @MCDB_Yale dlvr.it/TG1Vz2
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Quality Control in the Mass Spectrometry Proteomics Core: A Practical Primer · Journal of Biomolecular Techniques jbt.pubpub.org/pub/fid694bn/… --- #proteomics #prot-paper
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ASP3082 KRAS G12D PROTAC Preliminary data of dose escalation 👉 Low grade AEs mostly rash and IRR 👉 ORR 18.5% in PDAC, DCR 48.1% 👉 ORR 23.1% in NSCLC, DCR 84.3% Combination ongoing in CRC #ESMO24 #ESMO2024
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Ilaria Puoti retweeted
Guido Papa@guidovir_13 Sep 2024
Super excited to share our latest paper on a novel targeted protein degradation technology, now out in @CellCellPress. We introduce RING-Bait technology, an innovative approach to selectively target and degrade intracellular protein aggregates (1/7) cell.com/cell/fulltext/S0092…

Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function

RING-Bait technology hijacks the process of templated aggregation to recruit ubiquitination machinery and selectively degrade pathogenic tau assemblies without generating a specific binder, thereby...

cell.com
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A Framework for Quality Control in Quantitative Proteomics pubs.acs.org/doi/10.1021/acs… --- #proteomics #prot-paper
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Ilaria Puoti retweeted
Human Proteome
@hupo_org27 Aug 2024
The #HUPOECR & @EU_YPIC want to help elucidate the mystery of grant writing! ✍️ Join us on September 11 at 4PM GMT to hear from Dr. Mike MacCoss (@mjmaccoss), Dr. Rebekah Gundry (@Gundrylab), and Dr. Jesper Olsen (@jespervolsen) 🔥 Register today for free: shorturl.at/ZSLDX
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A real pleasure and privilege to host @RapeLab in Dundee @UoDCeTPD @UoDLifeSciences @mrcppu co-hosted woth @YKulathu ! Here in the highlight of the visit: lunch with our students and postdocs. thanks Micha for visiting!
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Are you working in #Clinical or translational research? Join @CharlesSwanton, @ClEllio, Andrew Tutt and Graham Cadwallader on 11 September to find out all about our clinical research vision & ask any questions you might have. Sign up now 👉 bit.ly/4bTJ1Yh @TheCrick | @ICR_London
Webinar, Clinical research statement of intent and funding. Register now. Image of researchers in conversation together. Cancer Research UK logo

ALT Webinar, Clinical research statement of intent and funding. Register now. Image of researchers in conversation together. Cancer Research UK logo

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On 24 June "Biomarkers in Industry, Health and Disease" symposium organised by the Edinburgh Association of Mass Spectrometrists will take place in IGC in Edinburgh (see the picture for details). It is free to attend but booking required. Booking link: eventbrite.com/e/symposium-b…
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1/7 @labs_mann and Georg Wallmann @GeorgWa are proud to announce alphaDIA, our open source, next generation DIA search engine. Check out the preprint @biorxivpreprint biorxiv.org/content/10.1101/…
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We are seeking a Scientist with research experience in organic synthesis and/or medicinal chemistry to join the drug discovery team based in the new Centre for Targeted Protein Degradation within Dundee's School of Life Sciences. buff.ly/3KnitDb
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No rest for TPD! After a busy start of the week we hope you can now relax and enjoy this month’s issue of the CeTPD Journal Club.
Centre for Targeted Protein Degradation@UoDCeTPD24 May 2024
We hope you had an amazing time at the #TPDfocus symposium. Catch up on other TPD highlights in April's Journal club now available 👇 buff.ly/44SkWiu Thanks to our amazing editors: Gemma, Tom and @AL_Harris20 #openaccess @UoDLifeSciences @alessiociulli @farnaby84
April Journal club front cover

ALT April Journal club front cover

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#TPDFocus symposium gala dinner and #Ceilidh with an amazing view 😍 @UoDCeTPD
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Having a good time at #TPDFocus @UoDCeTPD at the welcome meeting the old @CRUK_SI (Beatson) crew: @UbcH_Alice, @IPuoti, @dr_djmcg, @domi_89 - also #Brd4 is not detectable in the city #TPD
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Now Online Targeted protein degradation: from mechanisms to clinic dlvr.it/T69vDr
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From the prolific @LivUni team of @M_C_Schmid @AinhoaMielgo et al, another paper dissecting mechanistic underpinnings driving #PancreaticCancer metastasis. The authors identify four subtypes of “metastasis associated fibroblasts” or MAFs, of which hepatic stellate cell derived myMAFs play a pivotal role in the triumvirate of cancer cell, fibroblast & macrophage crosstalk. Signals from both metastatic cancer cells & macrophages (LIF & progranulin, respectively) are required to drive STAT3 dependent myMAF activation. These activated myMAFs in turn secrete osteopontin (aka SPP1), which promotes an immune suppressive metastatic milieu of macrophages, and drives cancer cell proliferation via periostin. What a complex web of interactions!! nature.com/articles/s41467-0… For other recent papers by this group dissecting pancreatic cancer metastatic mechanisms just this year alone, see: nature.com/articles/s43018-0… And aacrjournals.org/cancerres/a…
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Let’s give a big round of motivational applause to all international folks in academia who left their countries (plus family, language, and everything they grew up with) and moved elsewhere for their career development!👏Sometimes one needs that. 🌎🎓 nature.com/articles/d41586-0…

Citizenship privilege harms science

Nature - Researchers from the global south face often-distressing immigration bureaucracy that most from the global north do not. Six steps can begin to counteract this inequity.

nature.com
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We are delighted to share that our Director Professor @alessiociulli is part of the Cancer Grand Challenges KOODAC team! The team will use protein degradation strategies to target previously undruggable drivers of children’s cancers.
Cancer Grand Challenges
@CancerGrand6 Mar 2024
📢 Announcing five new global #CancerGrandChallenges teams! 📢 We're thrilled to announce five new teams, each receiving up to $25m over five years to tackle some of cancer's toughest challenges. Meet the teams: bit.ly/3Oqe58O @CR_UK @theNCI
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