@GestwickiLab

The Gestwicki Lab @UCSF uses #chemicalbiology and #biochemistry to understand the #proteostasis network. This account is student run.

Joined July 2019
  • Tweets146
  • Following259
  • Followers1.1K
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Proud to share this publication by our postdoc, Shweta Devi! It offers new insights into the interaction capabilities of the TPR domain to EEVD-like motifs in nonchaperone proteins. jbc.org/article/S0021-9258%2…

Exploration of the binding determinants of protein phosphatase 5 (PP5) reveals a chaperone-indepe...

The protein phosphatase 5 (PP5) is normally recruited to its substrates by the molecular chaperones, heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90). This interaction requires the...

jbc.org
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Excited to share the work done by @taiawu and Zach Gale-Day on DSFWorld: an online open-source software that streamlines the planning and analysis of DSF experiments! onlinelibrary.wiley.com/doi/…

DSFworld: A flexible and precise tool to analyze differential scanning fluorimetry data

Differential scanning fluorimetry (DSF) is a method to determine the apparent melting temperature (Tma) of a purified protein. In DSF, the raw unfolding curves from which Tma is calculated vary...

onlinelibrary.wiley.com
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Interested in learning how dyes might help in characterizing protein activity? We're excited to share the development of a protein-adaptive DSF platform (paDSF), a dye-based method used to interrogate stability, dynamics, and ligand binding! go.nature.com/4ajNRNp
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First woman to graduate from MIT was a chemist. She applied chemistry to issues like nutrition - a pioneer ahead of her time in many different ways #WomenInSTEM
Massachusetts Institute of Technology (MIT)
@MIT31 May 2023
Ellen Swallow Richards became MIT’s first female graduate when she earned her BS in chemistry on May 31, 1873 — 150 years ago today.
Black and white portrait photo of Ellen Swallow Richards .

ALT Black and white portrait photo of Ellen Swallow Richards .

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We’re thrilled to have Nick joining us!
Scripps Research Graduate Program@ScrippsGradPrgm16 May 2023
An alum of Prof. Jeff Kelly's lab, Nicholas Yan looks forward to a postdoc position in @UCSF's @GestwickiLab and @SouthworthLab, where he'll use cryo-electron microscopy to explore the structural basis of small molecules that target amyloid fibrils. More: scripps.edu/2023grads
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Congratulations to our amazing postdoc @proteins_emma on winning a poster award at the Protein Folding Dynamics Gordon Research Conference!!! It’s a well-earned testament to her brilliance & creativity!
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Huge congratulations to @CarolynBertozzi !!! What a well deserved honor.
The Nobel Prize
@NobelPrize5 Oct 2022
BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Gestwicki Lab retweeted
QBI@QBI_UCSF27 Sep 2022
As part of the #QBIChemBio22 Symposium today, @jadoudna, Nobel Laureate, co-inventor of #CRISPR-Cas9 & Professor at @UCSF/@UCBerkeley will participate in a Twitter Space hosted by Jason Gestwicki. Tune in at 1:30 PT to hear about her work! qbi.ucsf.edu/twitter-space-d…
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Gestwicki Lab retweeted
Ziyang Zhang@bignerdzzy21 Jul 2022
Jumping around the mutation alphabet to hit cancer! Our new work covalent targeting of KRAS G12S is online: nature.com/articles/s41589-0… Interested in more? The Zhang lab (thezlab.org) at @UCBerkeley is recruiting:)
Kevan Shokat@kevansf21 Jul 2022
#G12S The Next #KRAS oncogene targeted by covalent chemistry by @bignerdzzy who just started his lab @UCB_Chemistry (thezlab.org). Next up G12R. nature.com/articles/s41589-0…. @UCSFCancer @HHMINEWS @UCSF
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Gestwicki Lab retweeted
Frydman Lab@FrydmanLab19 Jul 2022
Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that are not generally toxic? A great collaboration with @GestwickiLab shows the way...cell.com/cell-chemical-biolo…

A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked...

Specific targeting of distinct Hsp70 sub-networks could be used to treat different diseases, such as cancer and virus infection, while minimizing side effects. Here, Shao and Taguwa et al. address...

cell.com
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Another great collaboration out today!
Frydman Lab@FrydmanLab19 Jul 2022
Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that are not generally toxic? A great collaboration with @GestwickiLab shows the way...cell.com/cell-chemical-biolo…

A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked...

Specific targeting of distinct Hsp70 sub-networks could be used to treat different diseases, such as cancer and virus infection, while minimizing side effects. Here, Shao and Taguwa et al. address...

cell.com
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Gestwicki Lab retweeted
Arun Wiita@apwiita18 Jul 2022
…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome! cell.com/cell-chemical-biolo…

Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor...

Ferguson et al. find that a class of HSP70 inhibitors (JG compounds) have increased potency against myeloma cells resistant to proteasome inhibitors. JGs localize to mitochondria, inhibit the...

cell.com
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It was fun to be a part of this exciting work!
Arun Wiita@apwiita18 Jul 2022
…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome! cell.com/cell-chemical-biolo…

Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor...

Ferguson et al. find that a class of HSP70 inhibitors (JG compounds) have increased potency against myeloma cells resistant to proteasome inhibitors. JGs localize to mitochondria, inhibit the...

cell.com
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Gestwicki Lab retweeted
Ziyang Zhang@bignerdzzy22 Jun 2022
I concur. I confirm that new PIs will do everything to make their mentees successful! I contend that other hashtags are also cool. I also confess that I’m a new PI @UCB_Chemistry and we are recruiting thezlab.org/

Zhang Lab @ UC Berkeley

The Zhang lab uses chemical synthesis to enable the study and therapeutic modulation of disease-specific targets or processes, with a particular focus on those involved in immune signaling.

thezlab.org
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Happy to share the @biorxivpreprint for my first bit of work w/ @aliceyting. Together with @heegwangroh, we built a simple and versatile single-component luminescent biosensor for detecting the SARS-CoV-2 spike protein. biorxiv.org/content/10.1101/…

A single-component luminescent biosensor for the SARS-CoV-2 spike protein

Many existing protein detection strategies depend on highly functionalized antibody reagents. A simpler and easier to produce class of detection reagent is highly desirable. We designed a single-co...

biorxiv.org
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Check out our latest review article on non-canonical Hsp70 interactions—out now in Cell Stress & Chaperones! With the recent explosion of studies mentioning them, @oletaknowsstuff & Jason thought this timely. We hope it inspires new important research! link.springer.com/article/10…

Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes

Cell Stress and Chaperones - Heat shock protein 70 (Hsp70) is a molecular chaperone and central regulator of protein homeostasis (proteostasis). Paramount to this role is Hsp70’s binding to...

link.springer.com
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Gestwicki Lab retweeted
Regan@ReganVolk2 Jun 2022
Absolutely thrilled to have this work published with RSC! Thank you again to my mentor @BalynZaro and co-authors Sara, Kate, and @Chemystified Check out my pinned tweet for a more detailed thread!
RSC Chemical Biology@rsc_chembio2 Jun 2022
🔥 New advance article for RSC Chemical Biology! 🔥 @BalynZaro et al @UCSF with the #proteomic characterization of phagocytic primary human monocyte-derived #macrophages! #chembio 🧐Read the #TransparentPeerReview #OpenAccess article 👉ow.ly/ptN550JkYjh
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That moment when @_heyheyMONET’s #PPGRetreat poster is so good you have to stop & check it out.
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Congrats to Taia Sean Wu @GestwickiLab, winner of the @UCSF Chancellor Award for Public Service. @taiawu decided to pursue a PhD in science after seeing the beauty of a protein structure at age 22. Now she works to give homeless youth the same opportunity.tinyurl.com/mr35aedu
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Congratulations to @taiawu on receiving the @UCSF Chancellor Award for Public Service. In addition to her outstanding research, Taia has served as an exceptional mentor & advocate for scientists at UCSF & across the SF Bay Area. We’d get specific, but it’s too much for a tweet!
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