@HirschLab

Latest news from Drug Design and Optimization at @Helmholtz_HIPS led by Prof. Dr. Anna K.H. Hirsch @Saar_Uni Account run by PhD students.

 Saarbrücken, Germany
helmholtz-hzi.de/en/the-hzi/locations/hips-saarbruecken/about-hips/
Joined May 2020
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We are looking for excellent candidates for three PD positions at the Department of Drug Design and Optimization, HIPS. You have a strong background in MedChem and synthesis of bioactive small molecules, then hurry up and apply! helmholtz-hzi.de/de/karriere…
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We are seeking excellent candidates for three PostDoc positions at the Department of Drug Design and Optimization, HIPS. If you have a strong background in MedChem and synthesis of bioactive small molecules, then feel free to apply! helmholtz-hzi.de/en/career/j…
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Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors (A. K. H. Hirsch et al.) @HirschLab #openaccess onlinelibrary.wiley.com/doi/…

Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors

Challenges in the discovery of selective IspE inhibitors with antibacterial activity and no toxicity: This work sheds light on the molecular properties for balancing enzymatic target and bacterial...

chemistry-europe.onlinelibrary.wiley.com
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#OnTheCover Front Cover: Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors (ChemMedChem 19/2023) (A. K. H. Hirsch et al.) @HirschLab onlinelibrary.wiley.com/doi/…
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🎉🔬🌟 Thrilled to announce our research hitting the cover of @ChemMedChem! 📰 Our article delves into the "Translational Gap of Escherichia coli IspE Inhibitors". Read it here : doi.org/10.1002/cmdc.2023003…

Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors

Challenges in the discovery of selective IspE inhibitors with antibacterial activity and no toxicity: This work sheds light on the molecular properties for balancing enzymatic target and bacterial...

chemistry-europe.onlinelibrary.wiley.com
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🎉 Exciting news! 📚🔬 Our group's new publication on "Inhibitors of Elastase LasB for Pseudomonas aeruginosa Lung Infections" is out now! 💡🦠 Offering promising avenues for treating this critical health concern. pubs.acs.org/doi/10.1021/acs…

Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

Abstract. Infections caused by the Gram-negative pathogen Pseudomonas aeruginosa are emerging worldwide as a major threat to human health. Conventional ant

pubs.acs.org
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Check out our new publication! : Exploring the translational gap of a novel class of Escherichia coli IspE inhibitors (dx.doi.org/10.1002/cmdc.2023…)

Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors

Challenges in the discovery of selective IspE inhibitors with antibacterial activity and no toxicity: This work sheds light on the molecular properties for balancing enzymatic target and bacterial...

chemistry-europe.onlinelibrary.wiley.com
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Artificial intelligence for natural product drug discovery bit.ly/488vLOB A review by a team including @marnixmedema @serina_robinson #rogerlinington @GJPvWesten @HirschLab covering synergies between omics-based natural product discovery and computational drug design
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Our own @GwenalleJZQUEL1 presented her work on LasB inhibitors at the @GDCh_aktuell Frontiers in Medicinal Chemistry in Vienna this past week!
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Congratulations to Prof. Rolf Hartmann for winning the Friedrich Stolz Award at the @GDCh_aktuell Frontiers in Medicinal Chemistry conference in Vienna!
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Congratulations to our own @AlaaAlhayek9 for winning the @GDCh_aktuell PhD Prize Award presented at the Frontiers in Medicinal Chemistry conference in Vienna!
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Best of luck to our brilliant colleagues who are embarking on their postdoc journeys in different corners of the world! @Rea_Nikolic94 will be working with @NewhouseGroup at @Yale, and @ZivotaSelakovic will be conducting research with @HirschLab at @Helmholtz_HIPS. 😊
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Looking for a PhD position in microbiome reseach? 👩‍🔬🧑‍🔬 Together with @Saar_Uni we are launching the EU-funded grad school @talentsGRAD and the recruiting process has just started! More details below or at talents-gradschool.eu. Please RT!
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Bei der Helmholtz Drug Discovery Conference 2023 #HDDC2023 am 15./16.5.2023 diskutieren Expert:innen die Herausforderungen & Chancen der modernen Arzneimittelforschung. 💊 ❗️Anmeldefrist für Vorträge & Poster ist der 1. 4.2023. @BronstrupLab @HirschLab helmholtz-hzi.de/en/news-eve…
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Anna Hirsch @HirschLab is co-organising the Frontiers in Medicinal Chemistry Conference, for which registration is now open: veranstaltungen.gdch.de/tms/…
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Die Wissenschaftlerin Mariia Nesterkina musste aus der Ukraine flüchten, konnte ihre Forschung aber in der Abteilung von Anna Hirsch (@HirschLab) am HIPS fortsetzen. Die Tagesschau berichtet über ihre Erfahrungen: tagesschau.de/wissen/forschu…
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Nice work @HirschLab! Congratulations!
Chemical Science@ChemicalScience22 Sep 2022
The first #ChemSciCovers for issue 36 is from @Helmholtz_HIPS and @HirschLab Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening READ HERE: ow.ly/9zV350KPYCe
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🆕#Review The Structures and Binding Modes of Small-#Molecule #Inhibitors of #Pseudomonas aeruginosa Elastase LasB by Dr. Anna K. H. Hirsch et al. from @Saar_Uni 👉mdpi.com/2079-6382/11/8/1060
Hirsch Lab@HirschLab24 Aug 2022
Our latest publication: "The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB" has been published in @antibioticsmdpi Congrats Virgyl and @GwenalleJZQUEL1! Read it here: t.ly/iJz4

The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase...

Elastase B (LasB) is a zinc metalloprotease and a crucial virulence factor of Pseudomonas aeruginosa. As the need for new strategies to fight antimicrobial resistance (AMR) constantly rises, this...

mdpi.com
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Our paper (mdpi.com/2079-6382/11/8/1060) was selected as an Editor's Choice article: The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB! #editorschoice

The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase...

Elastase B (LasB) is a zinc metalloprotease and a crucial virulence factor of Pseudomonas aeruginosa. As the need for new strategies to fight antimicrobial resistance (AMR) constantly rises, this...

mdpi.com
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#editorchoice The Structures and Binding Modes of Small-#Molecule Inhibitors of #Pseudomonas #aeruginosa Elastase LasB by Dr. Anna K. H. Hirsch et al. from @Saar_Uni 👉mdpi.com/2079-6382/11/8/1060
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