@HeinLab

Systems biology & viruses at the @MaxPerutzLabs & @MedUni_Wien • Led by #NewPl @marcoyannic

 Vienna, Austria
heinlab.org
Joined November 2022
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I am very grateful to work with so many talented and motivated trainees and colleagues. Shared @HeinLab, Barozzi lab and Winkler lab outing at a traditional Heuriger vineyard in Vienna. ☀️🍇
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Check out our new preprint, describing the transcriptional and proteomic events during Vaccinia virus infection in human cells. Spearheaded by the incomparable @alex___me, who spent a few super productive months with @lab_arias and me at the @czbiohub. #LoveVirology #PoxRocks
Alex Matía@alex___me17 Jan 2024
📢NEW PREPRINT ALERT! Thrilled to share our latest research delving deep into Vaccinia virus infection dynamics using scRNAseq and fractionation proteomics: -Antiviral response dynamics -Host and virus proteomic maps -Proteome relocation #lovevirology #poxrocks🧵👇
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Super happy that our SARS-CoV-2 host factor story is out at @NatureComms. doi.org/kx4x Preprint tweetorial 👇🏻 Updates since the first preprint 🧵👇🏻👇🏻
Marco Hein @marcoyannic.bsky.social@marcoyannic18 Jul 2022
🚨 New #LoveVirology preprint: This paper has it all: single cells, COVID, CRISPR & Sunshine! We systematically characterize host factors of SARS-CoV-2 using Perturb-seq. Led by @sarasunshinebio, bringing together @JswLab, Joe DeRisi's lab & many others doi.org/10.1101/2022.07.15.5… 1/
Schematic of the Perturb-seq workflow to study SARS-CoV-2 host factors (Fig. 1A of the paper): A sgRNA library targeting host factors of SARS-CoV-2 is delivered to Calu-3 cells stably expressing the CRISPRi machinery. The cells are then infected with SARS-CoV-2 and analyzed by single-cell RNA-seq, analyzing the expression of host and viral genes in 27k individual cells, and monitoring how perturbation of host factors changes the progression of infection and the activity of antiviral pathways.

ALT Schematic of the Perturb-seq workflow to study SARS-CoV-2 host factors (Fig. 1A of the paper): A sgRNA library targeting host factors of SARS-CoV-2 is delivered to Calu-3 cells stably expressing the CRISPRi machinery. The cells are then infected with SARS-CoV-2 and analyzed by single-cell RNA-seq, analyzing the expression of host and viral genes in 27k individual cells, and monitoring how perturbation of host factors changes the progression of infection and the activity of antiviral pathways.

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Sebastian Platzer (@Science_Seb) from @univienna joined the lab of Marco Hein (@HeinLab) at @MaxPerutzLabs to work on dissecting the interplay between virus replication and the host response at a systems level using single-cell functional genomics.
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Heading to Barcelona for the @GordonConf #VirusesAndCells. I’m super excited to meet old and new friends and many virology tweeps finally IRL!
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First time teaching as the new prof 👨🏻‍🏫
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The lab is growing! We welcome Kavya Shetty @sci_ko7 and Sebastian Platzer @Science_Seb, who are both starting their PhDs, and Julia Hufnagel @julia_jules_, who joins us for her BSc rotation project. Exciting times ahead! 📷: Max Kropitz/ @MaxPerutzLabs
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The Hein lab officially launched 🚀 and as an "inauguration gift", I was listed among the #HighlyCited2022 scientists 🥳 This week, I'm excited to interview candidates for the @viennabiocenter PhD program and hope to meet some future lab members!
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