Tuebingen, Germany
Joined June 2020
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- Following90
- Followers166
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Marcus Hartmann retweeted
Pleased to share our collaborative effort to develop anti-virulence agents. We unveiled a series of compounds targeting the transcriptional regulator HilD. Feedback is welcome!
Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Marcus Hartmann retweeted
We just released the "protein design toolkit", integrating tools from Damietta, ProteinMPNN and OpenMM.
An interactive tutorial is available at the server damietta.de. Recommended usage is described in the paper: doi.org/10.1093/nar/gkae297 and feedback is most welcome!
Marcus Hartmann retweeted
😁🎉😄🌟#NobelPrize!🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃😊🏆😁#PhysicsNobelPrize2023 for Ferenc Krausz, Max Planck Institute of Quantum Optics! 🎊😃🥰😆🥳😁😃🎉🏅😊🎈😁🥳😄🎊😁🌟😃🥰🏆😁🎉🎇😊🥳😄🌟🎈😁😃🥰🎉🏆😁🎊😊😄🥳🌟🎇😁🥰😃🎉🎈😁🏆😊😄🎊🥳😁🌟😃🥰🎉🏅😁🎈😊🥳😄🎉😁😍😁🎉🎇😊🥳😄🌟🎈🏆
Marcus Hartmann retweeted
A press release about our recent paper in @PNASNews
pnas.org/doi/10.1073/pnas.22…
Cyanobacterial protein integrates the circadian clock information
growkudos.com/publications/1… via @growkudos @uni_tue_exstra @CoE_CMFI @MPI_Bio
Marcus Hartmann retweeted
Fun fact: At 1.06 Å, this is the first-ever structure of any histone protein determined at atomic resolution - for what it's worth! 🤣
doi.org/10.1101/2023.02.26.5…
Marcus Hartmann retweeted
Congrats, truly seminal work! Since our initial discovery of bacterial histones, we too worked on the very same histone protein & now present its crystal structure & DNA-binding properties. Great work by Yimin, Birte & collaborators @HartmannLab @MPI_Bio
doi.org/10.1101/2023.02.26.5…
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Marcus Hartmann retweeted
An excellent perspective by authors from @AstraZeneca about fragment-based approaches to identify ligands for E3 ligases. Of especially high relevance for the field of targeted protein degradation (#TPD). @ACSBioMed pubs.acs.org/doi/10.1021/acs…
Marcus Hartmann retweeted
After long time in oven, happy to share w/ @HartmannLab @PNASNews
our work #Cyanobacteria #Carbon #Sensor SbtB possesses atypical #Redox regulated #Apyrase (hydrolysing ATP/ADP) to control HCO3 transport
Generous fund by @uni_tue_exstra @CoE_CMFI @MPI_Bio
pnas.org/doi/10.1073/pnas.22…
Marcus Hartmann retweeted
Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines sciencedirect.com/science/ar…
Marcus Hartmann retweeted
Speechless! HAPPY! Pinching ourselves! #NobelPrize2022 in Physiology or Medicine😁🥳😃🙃🤗😊🤗🙃🥳😃😁😀 🥳😃😁😀🙃🤗😊😆🤣😆Svante Pääbo @MPI_EVA_Leipzig 😆😊🤗@maxplanckpress 🙃😀😁😃🥳😃😀🙃🤗😊🤣😆🤣😊😊🤗🤗🙃🥳😀😆🤗😊🙃🥳😃😀😆😊🤗🙃🙂😄😲😀😁😃🥳🙃🤗😊🤗🙃🥳😃😁😀😲🥳😊 🥳
Marcus Hartmann retweeted
Happy to share our preprint with @HartmannLab &
@MichaHaff
Mechanistic & Structural insights of #Cyano Carbon Sensor #SbtB
SbtB possesses redox-regulated Apyrase activity to regulate HCO3- transporter #SbtA
@uni_tue @MPI_Bio @CoE_CMFI @SPP1879 @SCyCode1
biorxiv.org/content/10.1101/…
Marcus Hartmann retweeted
"Exploring protein-protein interactions at the proteome level" is not only a review article as an intro for my thesis but a statement of my current interest. Click here for free access until April 16, otherwise dm me, and I'll share it with you ;) authors.elsevier.com/c/1eeoX…
Marcus Hartmann retweeted
Also check out the News & Views on this paper by Marcus Hartmann (@HartmannLab): nature.com/articles/s41589-0…
Marcus Hartmann retweeted
Happy to share our work on #Cyanobacteria #Diurnal Metabolism
We show how #cdiAMP regulates #day-night cycling via #PII-like #SbtB & #Glycogen
Thanks to keyplayer @HartmannLab @JorgStulke @NielsN9
at @uni_tue @CoE_CMFI @MPI_for_DB @SPP1879 @ScienceAdvances
science.org/doi/10.1126/scia…
Marcus Hartmann retweeted
We are still looking for a postdoc.
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Marcus Hartmann retweeted
Sorry for repeating ourselves - but we are speechless AGAIN!😯🙂😯🙂😀🎉🤗🙃😯😁😃😁😯🙃🍾🎉😀🙂😃😁😯🙃🤗🍾🎉😀🙂😀🎉🍾🤗🙃😯😁😃😁😯🙃🤗🍾🎉😀🙂😯🙂😀🍾🎉#NobelPrizeChemistry2021 Benjamin List @maxplanckpress Max-Planck-Institut für Kohlenforschung🤗😯🙂😀🍾😯🎉🤗🙃😁😃😁🙃🤗🎉
Marcus Hartmann retweeted
We are speechless!🎉🙃😃🎉🎉🙃😃🤗🙃☺️🙃🙂😄🎉#NobelPrizePhysics 2021 😀🙃🎉☺️Klaus Hasselmann @MPI_Meteo😃🎉😃😀🙃😀🎉😊🙂🙃😀😄🎉@maxplanckpress🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🎉🙂🎉☺️🙃🎉🙂😀☺️🙃🎉🙂😀☺️🙃😀🙃😂😀🎉 😊🙂🙃😊😀😊🙃
Marcus Hartmann retweeted
Our paper on the accession of high-accuracy structure prediction in CASP14 is now out :) @HartmannLab @DanielRigden @AJSimpkin
onlinelibrary.wiley.com/doi/…
Marcus Hartmann retweeted
Check out our work on a novel flavoprotein DI(!)oxygenase prototype required for formation of bacterial tropone natural products that are important for many symbiotic interactions. Kudos to Ying Duan and Marina Toplak (collab. with the Dickschat Lab)
pubs.acs.org/doi/abs/10.1021…
Marcus Hartmann retweeted
Check out our latest results on the utility of CASP14 models for molecular replacement! Hats off to @cheshireminima @InuMassy @RandyJRead @DanielRigden @AJSimpkin @HartmannLab, Andrei Lupas, Arlie McCoy and Ronan Keegan. Always fun to collaborate with old colleagues :) @ccp4_mx
Assessing the utility of CASP14 models for molecular replacement biorxiv.org/cgi/content/shor… #biorxiv_bioinfo