@HarrisLabUTHSA
 San Antonio, Texas
labs.uthscsa.edu/rsh/
Joined November 2015
  • Tweets154
  • Following67
  • Followers327
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The Harris Lab retweeted
Avantika Gupta@AvanGupta16 May 2025
So excited to share our latest work with Sarat Chandarlapaty, @antoniomarraMD, Andrea Gazzo @MSKCancerCenter out today in @NatureGenet! We uncover the function and mechanism of APOBEC3-driven therapy resistance in breast cancer. 🧵 1/ nature.com/articles/s41588-0…

APOBEC3 mutagenesis drives therapy resistance in breast cancer

Nature Genetics - Analysis of a large cohort of metastatic breast cancer samples shows that APOBEC mutational signatures are enriched in post-treatment samples. APOBEC activity was also associated...

nature.com
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Great representation at the 1st Annual Biochemistry Research Day at UTSA.
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Carcinogens in tobacco smoke leave the genome vulnerable to deamination by viral restriction factor APOBEC3B. This new pattern of mutations known as “Didyma” can help delineate the origins a different cancers. Check out the full Pre-Print here: biorxiv.org/content/10.1101/…

Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis

Mutations in somatic cells are inflicted by both extrinsic and intrinsic sources and contribute over time to cancer. Tobacco smoke contains chemical carcinogens that have been causatively implicated...

biorxiv.org
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The Harris Lab retweeted
Rommie Amaro@RommieAmaro29 Apr 2024
🚨 APOBEC3B (A3B) is a major source of🧬mutation in cancer The active site is like Teflon (not much binds) BUT @Ozlem__Dmr discovered a druggable allosteric site 👀 Experiments by @DanHarki @_ChemKat @HarrisLabUTHSA 💪 biorxiv.org/content/10.1101/…
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The Harris Lab retweeted
DrayLab@dray_lab22 Mar 2024
What a great way to start the day. This superb work from the Pillai lab, driven by Prajwal Boddu and a little help from us @bdelapenavalos is finally in print @MolecularCell Highlight: SF3B1 oncogenic mutations reduce RNAPII gene-body elongation rate. sciencedirect.com/science/ar…
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The Harris Lab retweeted
SABCS@SABCSSanAntonio26 Feb 2024
We thank our program committee for creating a great #SABCS24 lineup. @VKaklamani @CarlosArteagaMD @BalkoLab @tperrybrown @heide_ford @HarrisLabUTHSA @TariKingMD @lab_kok @Adrianvlee @itsnot_pink @hmcarthur @dapattmd @c_sotiriou @atanmdlci @NeilVasan @adawaksmd @awolff @AACR_CEO
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📣 Hot off the press! @NAR_Open Delighted to share our latest work! Thanks to all collaborators and contributors.
DrayLab@dray_lab12 Dec 2023
Fresh off the press! The protein phosphatase EYA4 promotes homologous recombination through dephosphorylation of Y315 on RAD51. Hardest research paper since my postdoc years! Thx team! @bdelapenavalos @RTropee @DuijfLab @JeanYvesMasson @leunglaboratory academic.oup.com/nar/advance…

The protein phosphatase EYA4 promotes homologous recombination (HR) through dephosphorylation of...

Abstract. Efficient DNA repair and limitation of genome rearrangements rely on crosstalk between different DNA double-strand break (DSB) repair pathways, a

academic.oup.com
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Excited to share that our paper was officially published in Molecular Cancer!👇 Read more about EYA4 and its role in promoting breast cancer progression and metastasis here: rdcu.be/dnzkx A big thanks to @dray_lab and fantastic collaborators @RTropee and @DuijfLab.
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Congratulations to Arad and Sofia for defending their respective PhD theses! This marks the official sunset of the Minnesota Harris Lab. We wish them the very best in their next steps!
Sofia's defense

ALT Sofia's defense

Arad's defense

ALT Arad's defense

Arad and Sofia graduation ceremony

ALT Arad and Sofia graduation ceremony

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The Harris Lab retweeted
Elisa Fanunza@elisafanunza12 Aug 2023
Happy to share our last findings on HCMV evasion of APOBEC3 restriction!🤩 Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism | Journal of Virology journals.asm.org/doi/10.1128…

Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucle...

Human cytomegalovirus (HCMV) infections can range from asymptomatic to severe, particularly in neonates and immunocompromised patients. HCMV has evolved strategies to overcome host-encoded antiviral...

journals.asm.org
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Big news from Midwest AViDD Center featuring @elisafanunza @GuptaYogeshTX and Shaun Olsen
Midwest AViDD Center@MidwestAViDD5 Jul 2023
Midwest AViDD Center announces funding for six high-potential projects to further antiviral drug discovery midwestavidd.umn.edu/midwest… @umnmedschool
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Don't miss the great work by members of our virus team this year at ASV! Elisa is sharing her poster at 8:30 PM at P22-23 and Ashley's work can be found at P10-8. #ASV2023 #LoveVirology
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Check out the latest publication from PhD student Jordan Naumann! She utilizes the hydrodynamic FAH delivery system to show "DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo" mdpi.com/2312926 #mdpiijms via @IJMS_MDPI

DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo

Although the APOBEC3 family of single-stranded DNA cytosine deaminases is well-known for its antiviral factors, these enzymes are rapidly gaining attention as prominent sources of mutation in cancer....

mdpi.com
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Congratulations to Dr. Amanda Rieffer for a successful PhD thesis defense last Friday! We wish her the very best in all future endeavors!
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Beautiful story by our very own @JordanBeckerPhD and student @Ashley_Auerbach Congratulations on the cool discovery!
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Don't miss the latest work from our PhD student Arad, his gain-of-signal assay is prominently featured in @ScienceAdvances science.org/doi/10.1126/scia…

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors

Circulating SARS-CoV-2 variants show resistance to viral protease drugs, nirmatrelvir (Paxlovid) and ensitrelvir (Xocova).

science.org
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Congrats to our student Cameron Durfee and his preprint on #bioRxiv He demonstrates human APOBEC3B can drive tumor formation in vivo. Check out this beautiful story below!
bioRxiv@biorxivpreprint26 Feb 2023
Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases biorxiv.org/cgi/content/shor… #bioRxiv
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The Harris Lab retweeted
eLife - the journal@eLife30 Dec 2022
The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to the present day. elifesciences.org/articles/8…
A superposition of the three highest-ranked protein-protein docking models of the KSHV ORF61-A3Bctd complex in pink, yellow and blue, generated using RosettaDock

ALT A superposition of the three highest-ranked protein-protein docking models of the KSHV ORF61-A3Bctd complex in pink, yellow and blue, generated using RosettaDock

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The Harris Lab retweeted
Sofia Moraes@sofianmoraes5 Dec 2022
My 1st first-author manuscript is out in @eLife! This project started back in 2019 with the question “what makes a viral protein evolve a new function?” A thread: doi.org/10.7554/eLife.83893

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus...

The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to present day.

elifesciences.org
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Excited that my first co-first author paper was officially published today on mSphere! Read more about APOBEC3B nuclear localization here: journals.asm.org/doi/10.1128…
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