Group Leader @QIMRB_institute | Professor @medofak_uib | My lab studies how physiological stressors affect tumours | Formerly @RockefellerUniv @UTSWInternalMed
Brisbane, Queensland
Joined February 2020
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Halberglab retweeted
📢 We are hiring Group Leaders! 🌊
Come join our team @UiB to lead innovative research in molecular, cellular and organismal biology using marine/aquatic organisms! ⌛️ Application deadline Dec. 15. Share this exciting opportunity ⤵️
tinyurl.com/4bwn8u3n @embl @EMBRC_EU
Halberglab retweeted
15 PhD positions in an MSCA doctoral training network available. The network is about targeting RNA with small molecules (TargetRNA) and the positions span from molecular biology, chemistry, and computational design to structural biology and microbiology. uib.no/en/targetrna
Halberglab retweeted
I am very proud of the superstar postdoc @Yang_Haojun_01, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer.
nature.com/articles/s41586-0…
Exciting times ahead!
This month we are excited to welcome Professor Nils Halberg @Halberglab1 who has relocated from the University of Bergen in Norway to lead the new Cancer Metabolism Laboratory in the Institute’s Cancer Research Program.
Halberglab retweeted
🎦We are very excited to share a video abstract from first author @HoyerJorgen and Marios Chatzigeorgiou @mchlab presenting their recent article in @CurrentBiology on larval settlement in marine invertebrates. Produced by @MelBurford @UiB
Take a look! tinyurl.com/MSarsAbstract
Halberglab retweeted
RTs much appreciated... postdoc opp with our group! 🇳🇴💻🧬
We've had some success exploring (and predicting) disease progression with our "hypercubic inference" approaches. Join us looking at diabetes progression with multiomics data... good pay+great env! jobbnorge.no/en/available-jo…
Halberglab retweeted
📢 Registration is open!!
We are thrilled to announce registration for the 'Nordic Developmental Biology Societies & Michael Sars Symposium Joint Meeting' on May 28-31, 2024 is open!
Organized in collaboration with @swedbo & FSDB @UiB
✨REGISTER HERE ➡️ tinyurl.com/NDEVMSS24
Halberglab retweeted
📢 Save the date!
We are thrilled to announce the incredible lineup of speakers for our joint meeting with the Nordic Developmental Biology Societies on May 28-31 2024 in Bergen, Norway. Organized in collaboration with @swedbo & FSDB @UiB
Come join us! ⬇️
tinyurl.com/NDEVMSS24
Halberglab retweeted
Want to understand the evolution of first brains🧠?Come join us @MSarsCentre @UiB . Postdoc position available: "Decoding the gelatinous origins of brain evolution" as part of our @HFSP grant w Fred Wolf @uniGoettingen #ctenophores. RTs highly appreciated. jobbnorge.no/en/available-jo…
Halberglab retweeted
Presenting at the BBB seminar organized by the Dept. of Biomedicine, @Pawel_Burkhardt shared fascinating insights from his group on the evolution of first neurons and brains to a packed auditorium hosted by @Halberglab1 @medofak_uib @UiB ✨👏
Halberglab retweeted
Transfer RNAs (tRNAs) are increasingly found to play dynamic and critical regulatory roles in cancer progression. Alexandra Pinzaru's review describes this exciting area of research: nature.com/articles/s41568-0…
Halberglab retweeted
Are you a graduate student who wants to go directly to a junior faculty position? Apply now to the @Ludwig_Cancer Fellows program: ludwigcancerresearch.org/sci…. Great support, highly collaborative, and can be located in Oxford, Princeton or Lausanne. Let me know if you have questions.
Halberglab retweeted
Our paper debunking the 2020 cancer microbiome results is now published, in @mbiojournal. We'll see if @nature (or the authors) will retract these deeply flawed results. h/t @ProfBootyPhD @EricTopol journals.asm.org/doi/10.1128…
Halberglab retweeted
Check out these tutorials for applications of our pyPAGE package to gene-set enrichment analysis tasks. Thanks to @ArtemyBakulin for putting this all together.
Hey, everybody. As a follow-up to our pyPAGE paper we made a bunch of tutorials on how to apply it in various scenarios to perform differential gene-set enrichment analysis.
biorxiv.org/content/10.1101/…
We are hiring! Our lab is searching for PhD and postdoctoral candidates interested in the intersection between systemic metabolism and cancer. Please RT📣🙏jobbnorge.no/en/available-jo…
jobbnorge.no/en/available-jo…
Halberglab retweeted
A mind-blowing paper has come out today in @Nature
In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/scie…).
Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.
The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.
Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.
When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.
The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.
The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:
“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (scienmag.com/artificial-cell…)
nature.com/articles/s41586-0…
