Drug Discovery | Structural Biology | WDR protein family | PI at the SGC-University of Toronto | all opinions are my own.
SGC-Toronto
Joined March 2023
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Levon retweeted
New Blog Post 📢
Learn how @HalabelianLab utilizes AI-driven hit-finding technologies to discover small molecules targeting the WDR protein family and help elucidate the dark proteome.
#OpenScience #drugdiscovery #AI
thesgc.org/node/1649725
Levon retweeted
A comprehensive study by @HalabelianLab reveals the interaction of a small molecule which binds to Cbl-b and acts as an intramolecular glue locking the protein in an inactive state.
Read more: nature.com/articles/s42003-0…
Levon retweeted
Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intermolecular glue mechanism locking the protein in an inactive state: nature.com/articles/s42003-0…
@HalabelianLab @thesgconline
Levon retweeted
WDR proteins are a large, druggable, and underexplored target class with strong disease associations.
@HalabelianLab just released several WDR structures in complex with inhibitors, which were identified using DEL-ML, in collaboration with @Relay_Tx, @XChemInc and @Google.