Studying the gut microbial development and its associations with diseases with a specific focus on inflammatory bowel disease
Sheba Medical Center, TAU
Joined December 2021
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We emphasize the potential of using the microbiome, specifically the MHI, as an indicator of overall health and suggest that the MHI could serve as a rapid assessment tool to evaluate the effects of various interventions on participants' microbial and overall health.
In this paper, we demonstrate that a gut microbial health index (MHI), originally established through diverse human disease cohorts, is linked to lifestyle and diet, and we identify potential actionable strategies to enhance or negatively impact an individual's MHI.
Congratulations to co-authors in @HabermanLab, Sheba ARC Innovation Center, and Executive Survey on the publication in Gut Microbes. tandfonline.com/doi/full/10.…
HabermanLab retweeted
Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. nature.com/articles/s41587-0…
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our @MicahGoldrich and Louis Delhaye from @pieter_mestdagh. TL;DR we show that many of lncRNA chromatin occupancy maps are flawed🧵biorxiv.org/content/10.1101/…
HabermanLab retweeted
🍟 Ultra-processed and unhealthy diet exposure, combined with abnormal gut host and microbial signals, persists despite effective treatments in #CrohnsDisease. Addressing these gaps could improve patient health.
🔗 ow.ly/6xrg50YUzKC
HabermanLab retweeted
Rewarding to see our @HabermanLab study featured on the cover, laying the conceptual framework to underlying mechanism of escape from AT remission (=flare) d/t persistent dietary-metabolic gut perturbances. Hence the need for combined AT-nutrition trials
@HelmsleyTrust
📣 The May issue of #Gastroenterology is now online! This issue includes:
✅ The biography of the incoming AGA president
✅ A study on the role of APC mosaicism in #colorectaladenomas
✅ An article on a novel screening method for #ALD
✅ ...and more!
🔗 ow.ly/6N2q50YMLsP
HabermanLab retweeted
📣 The May issue of #Gastroenterology is now online! This issue includes:
✅ The biography of the incoming AGA president
✅ A study on the role of APC mosaicism in #colorectaladenomas
✅ An article on a novel screening method for #ALD
✅ ...and more!
🔗 ow.ly/6N2q50YMLsP
2/2 We use IBD proof-of-concept model for prioritizing epithelial-targeted metabolite interventions, showing: 1) IBD fecal contents disturb epithelial functions. 2) This was linked with metabolite levels, which 3) guided prioritizing metabolites that reversed IBD negative effects
1/2 Congratulations, Haya, Lubna, @HabermanLab, on the publication in Gut Microbes:
doi.org/10.1080/19490976.202…, where we try to address the related IBD epithelial dysfunction, which we also noted in this just-published paper in Gastroenterology
sciencedirect.com/science/ar…
2/2
We show that Crohn’s Disease advanced therapies address only one side of the disease: the immune response, while perturbations in diet, the microbiome, metabolites, and epithelial barrier function remain largely untouched during remission.
sciencedirect.com/science/ar…
1/2
Congratulations to Tzipi Braun, @HabermanLab, @ShomronH, IIRN CORE study on the publication in Gastroenterology @AGA_Gastro.
sciencedirect.com/science/ar…
We thank @HelmsleyTrust for their support and funding
HabermanLab retweeted
The Rosen lab at @StanfordMed identified a lipid-related metabolic dysfunction as a key feature of the #UlcerativeColitis epithelium.
They show the potential of patient-derived colonoids as a preclinical model to evaluate epithelial-targeted therapies: go.nature.com/3XYR9SE
HabermanLab retweeted
גיוס סגל אקדמי לפקולטה למדעי הרפואה והבריאות באוניברסיטת תל אביב לשנת הלימודים תשפ"ו . בית הספר לרפואה באוניברסיטת תל אביב מחפש מועמדות ומועמדים בכל הדרגות האקדמיות.
המשרה היא תקנית ועשויה להוביל למעמד של קביעות בתום תקופת הניסיון.
med.tau.ac.il/positions-med-…
HabermanLab retweeted
The School of Medicine @TelAvivUni seeks outstanding candidates to fill tenure-track faculty positions at level of Senior Lecturer/Assistant Professor & Associate Professor for fall of 2025. Deadline Oct 13, 2024. More info at: en-med.tau.ac.il/FOM-positio…
HabermanLab retweeted
Study in @NatureComms by @HabermanLab on the Urban-Rural diet-omic roots of IBD in China/Israel (our SOURCE @HelmsleyTrust consortium). Shows a gradient of IBD-like microbiome change correlating with time in city spent by villagers.
doi.org/10.1038/s41467-024-4…
@sheba_medical
HabermanLab retweeted
Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn’s disease, and celiac disease: buff.ly/43SbNnO
@HabermanLab @TelAvivUni
#Gastroenterology
1/6
In a new paper, we show that different diseases such as Alzheimer, Bipolar Disorder, Crohns' Disease, Chrohic Fatigue Syndrome, Lupus and Pancreatitis all share a similar microbial response:
genomebiology.biomedcentral.…
