@GuyOldrieve

Postdoctoral researcher at The University of Edinburgh

 Edinburgh, Scotland
goldrieve.github.io
Joined June 2017
  • Tweets36
  • Following236
  • Followers69
New paper to assist all looking at VSG expression diversity-another excellent effort from @GuyOldrieve vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression biorxiv.org/content/10.1101/…

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide...

Trypanosoma brucei is an extracellular eukaryotic parasite that causes sleeping sickness in humans and Nagana, Surra and Dourine in livestock, game animals and horses. The parasite displays an...

biorxiv.org
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Great to see this new work published from @GuyOldrieve and @KeithRMatthews @edin_eid showing how the parasites that cause sleeping sickness can spread beyond their native Africa as a result of mutations to key genes edinburgh-infectious-disease…
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Mechanisms of life cycle simplification in African trypanosomes biorxiv.org/content/10.1101/… A huge effort from @GuyOldrieve exploring how monomorphic trypanosomes can escape dependence on tsetse for their transmission and what it tells us about mechanisms of stumpy formation.

Mechanisms of life cycle simplification in African trypanosomes

African trypanosomes are important parasites in sub-Saharan Africa that undergo a quorum-sensing dependent development to morphologically stumpy forms in mammalian hosts to favour disease transmiss...

biorxiv.org
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Delighted to hear from both our Ker Memoral Prize winners @GuyOldrieve and Andy Gibson. Really well deserved winners! Congrats to both and read more about their work here: ed.ac.uk/edinburgh-infectiou… #EIDSymp24
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Our new study led by @scotomorph @MarquesCata We used Nanopore sequencing to map DNA replication across the whole T. brucei genome, revealing partitioning that drives instability for immune evasion @KathrynCrouch81 @emmabriggs6 biorxiv.org/content/10.1101/…

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and...

The genome of Trypanosoma brucei is structurally complex. Eleven megabase-sized chromosomes each comprise a transcribed core flanked by silent subtelomeres, housing thousands of Variant Surface...

biorxiv.org
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Another one through the gate. Congratulations Guy on your graduation! ⁦@SBSatEd⁩ ⁦@wt_hpgh⁩
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Can you store your trypanosome scRNA samples by freezing and still preserve their transcriptome? Yes you can! And you can map their cell cycle while you're at it. doi.org/10.7554/eLife.86325 @emmabriggs6 👏👏 @SBSatEd

Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell...

Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.

elifesciences.org
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And that leads us nicely to a group photo (the first of many, we're sure) of the #SALTTz attendees in the glorious Arusha sunshine!
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Really good to have all the ⁦@wt_hpgh⁩ PhD students together at the programme retreat in Crieff over the last couple of days😊
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Our paper is out in @BiologyOpen. Comparing closely related non-pathogenic trypanosomes, we highlight differential investment in cell-surface genes and predict this is associated with the life histories of their hosts and vectors journals.biologists.com/bio/… @KeithRMatthews
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Thanks to Guy Oldrieve @GuyOldrieve for sharing his experience of fee-free #openaccess publishing in @BiologyOpen via our #ReadAndPublish agreement with @EdinburghUni Read Guy's paper at bit.ly/3OmkccW Is your institution also participating? bit.ly/3O7BxGi
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A tough task in lockdown to cover this enormous topic but Eleanor Silvester & @Frank_Venter rose to the challenge. Parasite co-infection: an ecological, molecular and experimental perspective | Proceedings of the Royal Society B: Biological Sciences royalsocietypublishing.org/d…

Parasite co-infection: an ecological, molecular and experimental perspective

Abstract. Laboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, p

royalsocietypublishing.org
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Two closely related trypanosomes: one of bovines spread by tabanid flies, one of ovines spread by sheep keds. Why? There's only one way to find out... @GuyOldrieve 👏 The genomic basis of host and vector specificity in non-pathogenic trypanosomatids biorxiv.org/content/10.1101/…
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Very exciting to see our scRNA-seq analysis of BSF T. brucei differentiation out in @NatureComms this morning! My first corresponding author research article! 🍾 @KeithRMatthews @BiottofnI @rmc9z @dubafede nature.com/articles/s41467-0…
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Our paper on the intricacies of trypanosome taxonomy has been published!! @MicrobioSoc @KeithRMatthews @KamilSJaron Monomorphic Trypanozoon: towards reconciling phylogeny and pathologies microbiologyresearch.org/con…

Monomorphic Trypanozoon: towards reconciling phylogeny and pathologies

microbiologyresearch.org
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Delighted to see Guy's paper in final form! Highlights the challenges of nomenclature around trypanosomes in the field Monomorphic Trypanozoon: towards reconciling phylogeny and pathologies | Microbiology Society microbiologyresearch.org/con…

Monomorphic Trypanozoon: towards reconciling phylogeny and pathologies

microbiologyresearch.org
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Guy Oldrieve retweeted
ION_BRU@ION_BRU2 Jul 2021
We managed to fill a whole schedule without having a single SARS-CoV-2 talk. Science is healing.
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Guy Oldrieve retweeted
ION_BRU@ION_BRU2 Jul 2021
We'll here from @GuyOldrieve about investigating host specificity in trypanosomatids using nanopore sequencing.
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Pretty chuffed to see this being published - just a formal write up of some of the COVID modelling work we were doing in early 2020 (many thanks to nescafe double choc mocha packs for getting me through the writing) doi.org/10.1098/rstb.2020.02…
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My lockdown project is now available as a preprint 🎉 disq.us/t/3w88v62 @KeithRMatthews @KamilSJaron + Mylene & Laurent!
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