Parasitologist | McCulloch Lab @ University of Glasgow
Glasgow, Scotland
Joined December 2014
- Tweets226
- Following101
- Followers131
- Likes354
Marija Krasiļņikova retweeted
Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.
cell.com/cell-reports/fullte…
Big thanks to Mike Boemo
Marija Krasiļņikova retweeted
32 T2T!!!
Happy to share our preprint showing the molecular karyotype of #Trypanosomacruzi
@GonzaloGreif @fdiazviraque #MariaLChiribao @CarlosSanz22
@PacBio HiFi
biorxiv.org/content/10.1101/…
More recent work from the McCulloch lab! Check out Jeziel's @jezielbqi recent paper on R-loops, DNA replication and genomic stability in Leishmania major nature.com/articles/s41467-0… in @NatureComms @McCulloch_Group @MarquesCata @rmc9z @emmabriggs6
Marija Krasiļņikova retweeted
Excited to share our latest work on R-loops and RNAse H1, exploring their roles in genome replication timing and stability. It’s now published!
nature.com/articles/s41467-0…
@McCulloch_Group @emmabriggs6 @scotomorph @MarquesCata
Marija Krasiļņikova retweeted
We're pleased to share a new paper @UofGSii @WCIPGLASGOW led by @scotomorph @MarquesCata where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome. Well done Marija!
doi.org/10.1038/s41467-025-5…
DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s41467-025-5… thanks to @rmc9z @MarquesCata @emmabriggs6 Dario, Kathryn, Graham and Craig! 🥳
Marija Krasiļņikova retweeted
Drs Stephen Larcombe @jane_munday & @rmc9z highlight @MonicaMugnier & colleagues’ @Nature article on tissue spaces as #reservoirs of #AntigenicDiversity for #Trypanosoma #brucei. @SBSatEd @WCIPGLASGOW @UofGSii @JohnsHopkinsMMI @JohnsHopkinsSPH #Trypanosome
cell.com/trends/parasitology…
Marija Krasiļņikova retweeted
Are you interested in genome maintenance, organisation and replication?
We have a BBSRC-funded PhD position to use multi ‘omics’ approaches to tackle this problem! @McCulloch_Group @UniOfYork @YBRI_UoY findaphd.com/phds/project/ma…
Marija Krasiļņikova retweeted
Fancy a sneak peek into Leishmania’s unusual DNA replication programming? At @McCulloch_Group we used D-Nascent to map origins & forks at the single-molecule level, revealing novel, abundant replication initiation events across its plastic genome. See links below👇
How does Leishmania major replicate its genome? A sneaky Sneak Peek at a recent manuscript from our lab @McCulloch_Group (led by Jeziel @jezielbqi) currently under review:
dx.doi.org/10.2139/ssrn.5045…
Marija Krasiļņikova retweeted
Very happy to share new work @UofGSii @WCIPGLASGOW led by @jezielbqi describing very abundant, previously undetected DNA replication activity in Leshmania using DNAscent, a technique developed by @CNieduszynski Great work, Jeziel.
shorturl.at/G7uRm
Marija Krasiļņikova retweeted
Funded PhD available with us, @martllewellyn and James Cotton @UofGSii @UofGSBOHVM @WCIPGLASGOW to study genome replication and (in)stability across diverse kinetoplastids. Applications (via FindaPhD) taken from Nov 1st - Jan 12th. Enquiries welcome.
tinyurl.com/mfz4yh3k
Marija Krasiļņikova retweeted
Our new study led by @scotomorph @MarquesCata We used Nanopore sequencing to map DNA replication across the whole T. brucei genome, revealing partitioning that drives instability for immune evasion @KathrynCrouch81 @emmabriggs6
biorxiv.org/content/10.1101/…
Marija Krasiļņikova retweeted
We’re pleased to share a new study led by @jezielbqi describing how R-loops and RNase H1 dictate chromosome size-dependent DNA replication timing and genome stability in Leishmania @emmabriggs6 @scotomorph @MarquesCata
biorxiv.org/content/10.1101/…
Marija Krasiļņikova retweeted
We're very happy to share this study in @NAR_Open, led by @mggrzl and @emmabriggs6, describing R-loop interactors in T. brucei, including new functions in immune evasion. Great work, Mark, and thanks to all authors @UofGSii @WCIPGLASGOW
rb.gy/rnu7w
