Develops single-molecule imaging tools to gain detailed information about cellular nanoscale structures, dynamics, and molecular mechanisms.

Houston, TX
Joined November 2024
To mechanistically understand the flow-associated enhancements, we combined experiments with numerical simulations of mass transport, binding kinetics, and photobleaching in DNA-PAINT imaging with microfluidics.
1
12
Finally, we demonstrate microfluidics-enhanced multiplexed 3D DNA-PAINT imaging. By leveraging minimal custom instrumentation, this approach makes high-performance 3D and multiplexed DNA-PAINT imaging more accessible for biological and biomedical research.
10
Excited that our work on Microfluidics-Enhanced 3D DNA-Based Points Accumulation for Imaging in Nanoscale Topography has been published in ACS Applied Materials & Interfaces. doi.org/10.1021/acsami.6c115…
2
3
261
We show that imaging in a microfluidic chip reduces fluorescence background, improves localization precision, and increases both the number of localizations and signal photon counts under continuous flow.
1
18
In this work, we demonstrate microfluidics-enhanced 3D DNA-PAINT imaging using simple wide-field epi-illumination.
1
22
Excited to share that our work on Mitochondrial responses to conventional and ultra-high dose rate (FLASH) radiation has now been accepted for publication in the International Journal of Radiation Oncology – Biology – Physics (Red Journal). doi.org/10.1016/j.ijrobp.202…
1
1
125
In this work, we show that FLASH and conventional radiation achieve comparable tumor control in pancreatic cancer models, but FLASH better preserves mitochondrial function in normal pancreatic cells and reduces treatment-related toxicity.
1
14
These findings point to mitochondrial protection as a potential mechanism underlying the normal tissue-sparing benefits of FLASH radiation and may help guide the development of safer, more effective cancer treatments.
7
Excited that our work on versatile and scalable micromirror inserts that enable high-contrast and high-resolution light‑sheet microscopy in conventional sample chambers was featured on the cover of Nano Letters! Cover: pubs.acs.org/nalefd/issue/26… Paper: doi.org/10.1021/acs.nanolett…
5
458
Excited that our work on versatile and scalable micromirror inserts that enable high-contrast and high-resolution light‑sheet microscopy in conventional sample chambers is now published in Nano Letters! doi.org/10.1021/acs.nanolett… @ACSPublications @NanoLetters #soTILT3D #soLLS
1
4
171
Anna-Karin Gustavsson retweeted
1
67
Excited that our work led by the Dere Lab is now published! This study is the first to identify KDM4A as a centrosome protein, revealing its chromatin-independent function in maintaining centrosome integrity and genomic stability. #microscopy @FEBSJournal doi.org/10.1111/febs.70240
1
1
2
184
This discovery uncovers a previously unknown function of KDM4A in regulating mitotic fidelity, completing a ‘writer-reader-eraser’ epigenetic triad at the spindle!
26
Come join us for the 2nd Annual Rice University Center for Nanoscale Imaging Sciences Conference, taking place November 17-18. Learn more and register for free here: nis.rice.edu/2025-conference
1
37
The registration for the SMLMS 2025 is now open! 🎉 👉smlms.org/registration-and-s… Please share these news! The more the merrier! As most of our social media now runs via the blue sky, please follow us there for frequent updates (smlm-symposium.bsky.social)! Cheers! See you in August!
3
3
281
Anna-Karin Gustavsson retweeted
Thanks to @CPRITTexas awards over the last 14 years, @RiceUniversity has been steadily advancing #cancer research while recruiting 25 investigators who are discovering better ways to treat and prevent the disease. This is how we #EndCancer! research.rice.edu/r3/winter-…
8
14
982
Work lead by collaborator @isaacbhilton's lab on how biomolecular condensation of human IDRs initiates endogenous transcription via intrachromosomal looping or high-density promoter localization is now published in @NAR_Open as a Breakthrough Article! doi.org/10.1093/nar/gkaf056
Congrats to outstanding postdoc Jing Li on leading the newest paper from the lab with the amazing support from collaborators at Rice, UNC-CH, and Duke. We show that aberrant IDR fusions can provoke oncogenic gene expression via distinct engagement patterns with the human genome.
1
120
Anna-Karin Gustavsson retweeted
🔬Terrific work by @GustavssonLab!! They developed soTILT3D, a single-objective light sheet that enables precise, high-speed, multi-target 3D single-molecule super-resolution imaging of whole cells. 💫Our anti-mouse, rabbit, & goat binders were used to visualize Tomm20, Tubulin, Lamin A/C, Ezrin, LAP2, & Lamin B1 doi.org/10.1038/s41467-024-5…
1
2
318
Thanks so much for your support!
Rice University awards seven research partnerships through the Provost’s TMC Collaborator Fund, uniting Rice expertise with Texas Medical Center institutions to advance breakthroughs in cancer research, medical ethics, and health care. bit.ly/4h0GrCI
2
63