@GuptaLab1

We make tools that render a quantitative view of #membraneproteins and #lipids at the #cellmembrane @YaleCellBio. #Massspectrometers are our favorite toys

 Yale School of Medicine
theguptalab.com/
Joined October 2021
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8Media
Meet us @moitrayee_lab at #BPS2024 with posters from @GTWalker7 and @Rachelmcalli and my talk at the #FutureofBiophysics Burroughs Wellcome Fund symposium. We will highlight our work on determining #membraneprotein #organization and #structure directly from native #membranes.
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See our lab's latest JASMS publication! In this work, our lab deploys this quantitative CIU methodology to measure isomass pairs of biotherapeutics. Find it here: pubs.acs.org/articlesonreque… #ASMS #JASMS #CIU #MassSpec #anitbodies
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Kallol Gupta retweeted
Melia Lab@TJ_MeliaLab15 Aug 2023
Congrats Justin! Really nice work showing ATG2 function on monolayer-wrapped LDs and careful characterization of a transport dead mutant which loses bridge-like but not shuttle-like lipid transport capacity. Thanks also to @Rachid_Thiam for cool studies with monolayer mimics.
Justin Korfhage@JLeonard_0115 Aug 2023
I’m excited to finally share this project from the @TJ_MeliaLab where we demonstrate that the lipid transport protein ATG2 is active and highly efficient on phospholipid monolayers. (1/3) biorxiv.org/content/10.1101/…

ATG2A-mediated bridge-like lipid transport regulates lipid droplet accumulation

ATG2 proteins facilitate bulk lipid transport between membranes. ATG2 is an essential autophagy protein, but ATG2 also localizes to lipid droplets (LDs), and genetic depletion of ATG2 increases LD...

biorxiv.org
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Check out our new study published at @NatureComms in which we investigated the Akt1 #signaling and dynamics using an optogenetic-phosphoproteomic system, or Optop-DIA! nature.com/articles/s41467-0… @YalePharm @CancerYale@YaleWestCampus@yalemed 1/4
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In boost for precision drug screening, chemical ‘supercharger’ solves molecular membrane mystery bit.ly/nano-membrane Breakthrough science @GuptaLab1 @naturemethods @Yale @YaleCellBio
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Our latest work on #bioRxiv answers a simple question: can you see cellular substructures and ultrastructure without fluorescence, or even a 🔬? - Yes, you can! With #UnclearingMicroscopy! @OnsMSaad1 @mshribak @YaleCellBio biorxiv.org/content/10.1101/…
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