Neurobiologist interested in myelin, inflammation, and degeneration of the diseased and aging nervous system.
Würzburg, Munich
Joined February 2021
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Now published in the June issue
@NatureNeuro
I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover. #Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple. Thanks @ElisaFlo04 & co!
Janos Groh retweeted
Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature:
Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.
nature.com/articles/s41586-0…
#immunology #cellbiology @immunox @ucsf
Janos Groh retweeted
Thrilled to share our invited Nature Reviews Neuroscience review on the role of peripheral immunity in Alzheimer’s disease.
Honored to write this piece with outstanding colleagues @KuchrooLab, @RudyTanzi, @weinerlabhms, Mehdi Jorfi and rising stars from my lab Neta Rosenzweig and Kilian Kleemann.
My sincere thanks to Editor Katherine Whalley for the invitation.
The time has come to deeply investigate peripheral immunity in AD.
Review @NatRevNeurosci @OlegButovsky
Immune dysfunction in Alzheimer disease
nature.com/articles/s41583-0…
Janos Groh retweeted
Online now: Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions dlvr.it/TNy4x2
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in @ImmunityCP offers some hints.
cell.com/immunity/fulltext/S…
Congrats @fngruqng2, @LenaSpieth, @LuLiu_Laura, @StefanBerghoff, @vinitiwari1 et al.
Janos Groh retweeted
Join us 10/30 for a @Labroots webinar with Dr. Janos Groh: From Myelin Damage to Immune Dysfunction: Unravelling the Aging Brain.
Hear how single-cell + spatial transcriptomics reveal glial–immune interactions driving neurodegeneration.
Register: hubs.ly/Q03N0rVJ0
Janos Groh retweeted
When it comes to aging, the health of even the smallest vessels is critical to maintaining cognitive function.
New study in @Nature finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: nature.com/articles/s41593-0…
Janos Groh retweeted
Happy to share this review article published in @RockUPress @JExpMed today. Thankyou Mika and @Lucie_JExpMed for the opportunity !! 🥳
@UCSDHealth @TU_Muenchen @DZNE_en
#Microglia #Inflammation #Lipids #CNS
Glial cells & lipoproteins coordinate lipid & immune signaling to regulate CNS #inflammation. @vinitiwari1 & Mikael Simons review the relationship btwn lipid metabolism & inflammation & how disruptions in this interplay contribute to neurological disorders hubs.la/Q03BkF6r0
Janos Groh retweeted
Are T cells in the brain friend or foe? In tauopathy mice, CD8⁺ T cells can slow pathology. In older, wild-type mice, they damage the optic nerve. (@NINDSnews @NIH @tumuenchen ow.ly/5yc650Wos1Y
Janos Groh retweeted
New study featured on the June cover of Nature Neuroscience used Vizgen’s MERSCOPE® to uncover how microglia and CD8⁺ T cells drive white matter degeneration in aging brains.
Learn more: hubs.ly/Q03sqNtp0
Janos Groh retweeted
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
nature.com/articles/s41593-0… @NatureNeuro
Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
nature.com/articles/s41593-0…
See also this excellent News & Views from Jonathan Monteiro and Veronique Miron. nature.com/articles/s41593-0…
Janos Groh retweeted
To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by @AGuskjolen . We hope you enjoy every single piece of it as much as we do!
cell.com/neuron/current
Happy to share this recent review with Mika Simons - White matter aging and its impact on brain function: Neuron cell.com/neuron/fulltext/S08…
Janos Groh retweeted
nature.com/articles/s41467-0…
I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:
Janos Groh retweeted
🚨NEW PAPER ALERT 🚨 Our paper just got published in @ImmunityCP ! From Munich with 🥨 Check it out here: cell.com/immunity/fulltext/S… @Seiji_Kaji, @StefanBerghoff, Mikael Simons #apoe #Alzheimers #microglia 1/9
Janos Groh retweeted
🎉Excited to share that my PhD work is out @ImmunityCP. We show that epigenetic reprogramming via innate immune training with BCG vaccination or KO of HDAC1/2 in microglia enhances remyelination in aging, highlighting mechanisms of age-associated decline in myelin repair(1/1)
Online now: Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system dlvr.it/TB1L2G
Janos Groh retweeted
In a mouse model of #Alzheimer’s disease, amyloidosis itself triggers age-related #oligodendrocyte and #myelin damage mediated by CD8+ T cells that promote the accumulation of interferon-activated myelin-damaging #microglia
nature.com/articles/s41593-0…
