@GranucciLab

Cellular and Molecular Immunology Laboratory headed by Professor Francesca Granucci at @BtBsUNIMIB - University of Milano-Bicocca

 Milan
Joined March 2021
  • Tweets167
  • Following266
  • Followers372
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🚨 Glad to share our new paper, out now in Nature Immunology!!! nature.com/articles/s41590-0… We identify microbial adhesion as a previously unrecognized danger signal that activates Piezo1 in myeloid cells before PRR engagement.

Microbial adhesion promotes Piezo1 activation to initiate innate immunity

Nature Immunology - Granucci and colleagues identify microbial adhesion to myeloid cells as a critical initiating event that precedes engagement of pattern recognition receptors.

nature.com
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Replying to @GranucciLab
@GranucciLab - Il sistema immunitario “sente” fisicamente i microbi prima ancora di riconoscerli come tali - Le Scienze. @unimib #BtBsUNIMIB lescienze.it/comunicati-stam…

Il sistema immunitario “sente” fisicamente i microbi prima ancora di riconoscerli come tali

Grazie al “contatto fisico” dei microrganismi con le cellule immunitarie, l’organismo percepisce il segnale di allarme e attiva la reazione del sistema immunit…

lescienze.it
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Grazie al “contatto fisico” dei microrganismi con le cellule immunitarie, l’organismo percepisce il segnale di allarme e attiva la reazione del sistema immunitario più velocemente. 🔬Lo studio in collaborazione con @LaStatale, @unipv e @SanRaffaeleMI unimib.it/comunicati/sistema…

Il sistema immunitario “sente” fisicamente i microbi prima ancora di riconoscerli come tali

unimib.it
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Missed the full #story? Here’s the 2-minute version 👀 Our #Research Briefing in @NatImmunol is out: how microbial adhesion and #Piezo1 initiate innate #immunity before canonical PRR recognition. @Metello_Inn Briefing: nature.com/articles/s41590-0… Free pdf: rdcu.be/ANm25wd4PkRa

Dendritic cells sense microbial adhesion to launch innate immunity

Nature Immunology - In a mouse skin infection model, microbial adhesion to CD11c+ myeloid cells activates PIEZO1 and an LTB4–IL-1α–CXCL1 cascade that recruits neutrophils before...

nature.com
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How do mammals mount an effective #ImmuneResponse? 🧩 Dr. Francesca Granucci's lab has uncovered another piece of the puzzle by uncovering microbial adhesion to myeloid cells as a critical initiation event. Abstract in @NatImmunol: go.nature.com/4iZDEhb
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Granucci Lab retweeted
Waggoner Lab@LabWaggonerSep 11
In a mouse skin infection model, microbial adhesion to CD11c+ myeloid cells activates PIEZO1 and an LTB4–IL-1α–CXCL1 cascade that recruits neutrophils before Toll-like receptor signaling becomes dominant nature.com/articles/s41590-0… nature.com/articles/s41590-0… @NatImmunol 🇮🇹
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Many thanks to all the people who worked in this project @GiuliaStucchi2 @dendriticell @Metello_Inn @GiuseppeRocca16 @Ste_cozzi @OstuniLab @BtBsUNIMIB @unimib
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Great time at #SIICA2026 in Brescia last week! Our group was thrilled to present our latest work through oral and poster presentations, winning Best Oral Presentation with @ACelant2 ! Proud of the team and grateful for the inspiring discussions!
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The @FEBS_Letters Special Issue on dendritic cell biology is now online, offering a timely overview of recent progress in the field. It was a pleasure to be involved as a guest editor with @dendriticell & @frarro1
FEBS Letters@FEBS_Letters28 Jul 2025
Our special issue on dendritic cell biology in health and disease is online now! Featuring 7 free Review articles on the role of dendritic cells in metabolism, cancer, and immunity, and more. Read the issue for free here ➡️ tinyurl.com/2zw4znee #dendriticcells #immunology @frarro1 @dendriticell
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✨ That’s a wrap on The Power of Multiplexed Imaging! A full week of hands-on sessions, inspiring lectures, a great seminar, and data analysis! Huge thanks to all participants for your energy. Can’t wait for the next edition — stay tuned! 🔬🌈 #MultiplexImaging #SpatialBiology
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A huge thank you to all our sponsors for their invaluable support — none of this would have been possible without you! 🙏 @unimib @BtBsUNIMIB @FrontImmunol @Indica_Labs @AiviaSoftware @thermofisher @CellSignal @BioLegend
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A special thank you to Dr. Bruno Charbit from the Colin Chu Lab for joining us and delivering an inspiring scientific seminar. Your insights sparked gave our participants a deeper look into cutting-edge multiplexed imaging. 🔬👏
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We had a great time at #SIICA2025 in beautiful Perugia! 🌿 It was a pleasure to share our research, connect with the community, and be inspired by so much great science. Special shoutout to our @GiuseppeRocca16 for winning the Best Poster Award – well deserved! 🏆🎉 #Immunology
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🚀 Registrations are OPEN! Join the 2nd edition of The Power of Multiplexed Imaging — a deep dive into spatial biology. 🔬 Inspiring talks, hands-on training, cutting-edge tech! Secure your spot 👉 academy.unimib.it/power-adva… #MultiplexedImaging #SpatialBiology #ImagingCourse
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✨ Reminiscing about last year’s multiplexed imaging course—such a fantastic experience! 🤩 We were thrilled to have @colinchu72, along with all the students & guests! Truly inspiring days of learning. Big things coming—stay tuned! 👀🚀🔬 #SpatialBiology #MultiplexImaging
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Excited to share our new editorial in Nanomedicine on engineering immunity with nanoparticles! 🧬✨ We explore insights into recent advances in transplant rejection therapy. A must-read for #Nanomedicine & #TransplantImmunology! doi.org/10.1080/17435889.202… @dendriticell @Ste_cozzi

Engineering immunity with nanoparticles: highlights from recent research on transplant rejection...

Published in Nanomedicine (Vol. 20, No. 4, 2025)

tandfonline.com
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Interested in Engineering #immunity with #nanoparticles for #transplant #therapy? Have a look at our latest opinion and brief recap in the field! 👇👇👇 credit to @GranucciLab @ste_cozzi tandfonline.com/doi/full/10.…

Engineering immunity with nanoparticles: highlights from recent research on transplant rejection...

Published in Nanomedicine (Vol. 20, No. 4, 2025)

tandfonline.com
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#Tissueresistant to tumorigenesis. How intestinal tissue operates #regeneration after damage preventing tumorigenesis. nature.com/articles/s41586-0…

Liver X receptor unlinks intestinal regeneration and tumorigenesis

Nature - Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

nature.com
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Super excited to finally post about our neutrophil project, led by our very own @GiuliaStucchi2. 🎉 We discovered an unforeseen two-tier mechanism of neutrophil recruitment during infections, in which mechanosensing is key to initiating innate immunity. biorxiv.org/content/10.1101/…

Mechanoreceptors initiate innate immunity in response to microbial infections

How mammals mount an effective immune response against infectious agents remains an unresolved fundamental issue in biology. Here, we discovered an unforeseen two-tier mechanism of neutrophil...

biorxiv.org
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Shoutout to the amazing team behind this work! @dendriticell @GiuseppeRocca16 @ACelant2 @Ste_cozzi @Metello_Inn @BtBsUNIMIB
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