We study the relationship that exists between the occurrence of new mutations and the regulation of cell fate choices in the male germline @MRC_WIMM
Oxford, United Kingdom
Joined August 2020
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Our lab, together with others, have secured funding for a project titled “Making it personal”, which uses theatre to explore public perception of a new form of genetic testing. Read more below....
imm.ox.ac.uk/news/PCER-award…
Introducing our latest paper (doi.org/10.1111/andr.13766) : "can the male germline offer insight into mammalian brain expansion?"
Its contents in brief: we think so.
Goriely Lab retweeted
The genes that influence menopause timing are also linked to cancer risk and newly arising mutations in egg cells.
Balancing the benefits of future treatments to extend fertility with the potential risks will be important, says @GorielyLab. go.nature.com/4d4sUYq
Goriely Lab retweeted
🚨 Job alert
Hiring a postdoc (comp or wet lab) to work on chromatin & genetics 🧬
Come work with us @HumanGeneticsOx in the beautiful @UniofOxford
🗓️ Closing September 13th
Details at beagrielab.com/join
Pls share and RT!
#PostdocJobs #GeneticsJobs #genomics #cohesin
Goriely Lab retweeted
After a few years of work, we have identified the first non RAS/MAPK pathway gene which is under 'selfish selection' in the male germline. With implications for those with @MyhreSyndrome, our seminal work is published in @AJHGNews
Hot off the press! Our latest publication “SMAD4 mutations causing Myhre syndrome are under positive selection in the male germline”, is out today in @AJHGnews! tinyurl.com/889mn4mj – the result of a fruitful collaboration with the Tartaglia lab in Rome
Hot off the press! Our latest publication “SMAD4 mutations causing Myhre syndrome are under positive selection in the male germline”, is out today in @AJHGnews! tinyurl.com/889mn4mj – the result of a fruitful collaboration with the Tartaglia lab in Rome
SMAD4 is the first PAE gene operating outside the RAS-MAPK pathway @RASopathiesnet. This finding raises the exciting possibility that other genes and signalling pathways may be under positive selection in the male germline.
We wish @educalpena all the best on his PI endeavours in Valencia. His wealth of knowledge and infectious personality will be missed!
It's a momentous week: after 8 years in the Wilkie Lab, our former postdoc/visiting researcher @educalpena is leaving Oxford to become a Principal Investigator at @IISLaFe in Valencia 🧬🇪🇸
Congratulations to Edu, and farewell - we wish you the best of luck with your next steps!
ALT Edu and Andrew Wilkie at a farewell dinner.
ALT The Wilkie and Goriely Group around a table at Edu's farewell dinner.
ALT Edu pictured, sat down, presenting at his last lab meeting with the group.
Pregnancy decisions can be hard after having a child w/ a genetic condition. Latest @Gorielylab research on a new strategy:“Professionals’ views on providing personalized recurrence risks for de novo mutations”@AliMakesHay JWells @AGoriely NHallowell bit.ly/4cgOr0o 1/10
A further finding is that giving personalised risk information with a non-directive approach may create patient burden. Securing understanding for autonomous decision-making may be hard to achieve and couples may want more guidance. Research with couples is planned. 9/10
We are grateful to all our participants and to our funders @OxfordBRC @Wellcometrust for making this research possible. Thank you also to our reviewers and editors at The Journal of Genetic Counseling for giving us the opportunity to share our findings. 10/10