Congrats to our CRISPy fresh doctor 👏👏 Marcel McCullough for successfully defending his PhD thesis: 🧬✂️Combinatorial Gene Editing in Human Cells to Model Deficiencies of DNA Repair in Cancer Thx to committee members @CeronLab @LValleResearch and @DSzuts for great discussion!

Double PhD defense day in the lab 🤩 Congrats to our dr. Guille Palou @gpaloumarquez, fresh from the oven 🎊🥳 and similarly so our newly-minted dr. Ignasi Toledano @IgnasiToledano! Amazing defense both, bravo 👏👏

The youngsters from lab are at @EMBLEvents DNA Replication symposium #EESreplication 🧬 Our alumna dr. Marina @msalvadoresf and PhD Marcell @MarcellVeiner gave talks on their recent work 👏-- identifying DNA replication origins by mutation patterns and neural nets🤖

📃"Joint inference of mutational signatures from indels and single-nucleotide substitutions reveals prognostic impact of homologous recombination deficiency in tumors" 🔗researchsquare.com/article/r… (3/3)

This "multimodal" approach extracts a cleaner SBS3, a tricky but important mut sig ➡️splits into SBS3a and SBS3b, based on indels ➡️cleaner link w/ BRCA2 variants ➡️strongly predicts survival in 4 cohorts of ovarian cancer (incl @deciderproject) (2/3) 👇Check out our preprint:

❓Want to learn an easy trick to improve your mutational signatures? ‼️Extract them from SNV and indel mutations jointly! A study by our Patricia F. @pferrert now online, focusing on HR deficiency signature SBS3🧬 Here is a TL;DR for you 👇 (1/3)

.@FranSupek presented Marina's @msalvadoresf study on large-scale mutation risk in cancer genomes ➡️nature.com/articles/s43018-0… at the Nobel Minisymposium No. 60 "Somatic mutation in aging" in Stockholm. Thanks to organizers for inviting! – at Stockholm, Sweden

First 3 doctoral theses #PhDone from our GenomeDataLab, and all 3 receiving the "cum laude" qualification! 🎊 👏👏👏 to David @davidmasp, Elizaveta B. and Marina @msalvadoresf, the 3 genomics musketeers! You rock! – at Barcelona, Spain

🔥🔥BRIC group leader positions (incl associate professorship or full professorship at @UCPH_Research, a leading 🇪🇺 uni) - broad search - interests: stem cell, neuro, cancer - core funded position - top-notch science - collaborative workplace Join us! ➡️tinyurl.com/BRICgroupleader

📜4/4 The David @davidmasp preprint Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylation. biorxiv.org/content/10.1101/… ~fin~