Scientist studying mutagenesis and cancer at the Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest
Budapest, Hungary
Joined April 2022
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Are pesticides mutagenic? We assayed the mutagenicity of all six IARC 'probably carcinogenic' pesticides in cell culture and found that two were mutagenic with specific spectra, but #glyphosate was not. See in @chemosphere sciencedirect.com/science/ar…
DNA repair and mutagenesis are intricately linked - our comprehensive review on mutagenesis due to defects in each repair pathway is now out @repair_dna
doi.org/10.1016/j.dnarep.202…
Opulent environment at the excellent #MITS24 mutation meeting in Edinburgh, where Eszter Németh won a poster prize!
It was an honour to attend the inaugural lecture of Katalin Karikó at the Hungarian Academy of Sciences. An inspirational story from a very humble person.
Great news that our institute's DNA repair community is expanding! Also, to keep with the times, we have changed the name of the institute from Enzymology to Molecular Life Sciences.
I'm excited to share that I'm joining the Institute of Molecular Life Sciences at the HUN-REN RCNS in Budapest as a Group Leader. My lab will investigate DNA repair mechanisms in terminally differentiated cells. ronalab.org/
New year, new species! Pleased to report the mutagenic effect of regeneration in collab with Jelena Vermezovic @IFOMresearch @NAR_Open: Mutational profile of the regenerative process and de novo genome assembly of the planarian Schmidtea polychroa academic.oup.com/nar/article…
A short but very inspiring visit to Claus Sørensen's lab, presenting our latest results on DNA damage bypass at @UCPH_BRIC Uni of Copenhagen
Mismatch repair is very important to avoid mutagenesis, but how do mismatches arise? In a fresh NAR paper we show that oxygen triggers mismatches through a replicative process rather than direct DNA damage. academic.oup.com/nar/article…
Listen to this, it is all so human.
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges.
Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.
Listen now:
What are the main causes of spontaneous mutagenesis? Proud to present our new paper reporting that translesion synthesis (REV1) or oxidative processes (via PRIMPOL) are responsible for mutations in cultured human cells cell.com/cell-reports/fullte…
Thank you for the summary, @AdamsBioAging
Honoured to present our findings on oxygen-dependent mutagenesis in mismatch repair deficient cells at the FEBS congress #FEBS2023
Makes very good sense!
Delighted to share our new paper on the physiological role of ATR in normal replication (without stress). In brief, Demis found that ATR prevents the exhaustion of dNTP and other replication proteins in the early S phase by tempering origin firing. nature.com/articles/s41467-0…
