Associate Professor of Biochemistry and Molecular Biophysics at Washington University
Saint Louis, MO
Joined September 2020
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Our new manuscript born of work led by lab members @thedrakejensen and Ana Ruiz Manzano is now available @NAR_Open.
It describes a fluorescent-aptamer-based transcription assay for parallel steady state rate measurements:
doi.org/10.1093/nar/gkad761
The @WUSM_BMB holdiay door competition is on! Come check out our pumpkin spider spinning a nucleic acid web made from the bones of its NTP prey. And just a warning the door is now held shut by a couple of base-pairs. You will have to pull harder than usual. 😉
Welcome to Victor Tyne, a physics and classics major @UChicago , who will spend time with us as part of the brand new @WUSM_BMB summer undergraduate research program:
biochem.wustl.edu/studentinf…
Congratulations to lab members @thedrakejensen and Eric Tomko on receiving @WUSM_BMB seed grants for their proposed projects. Well done!
Eric Galburt retweeted
Spread the news, we have two open calls for tenure track group leader positions @PoLDresden !!
@Lohman_Lab already beat me to it, but really elegant work by graduate student Ankita Chadda in the lab reveals a new twist on UvrD-family helicase dimerization. Perhaps most exciting are the implications for DNA repair in M. tuberculosis.
pnas.org/content/119/8/e2114…
For those who will be in #SanFrancisco for the @BiophysicalSoc meeting, make sure you come hear Ankita's platform talk on Wed, Feb 23rd (2157-Plat).
She will detail how oxidative conditions lead to UvrD1 dimerization and helicase activation via a specific 2B domain cysteine.
Eric Galburt retweeted
Students interested in Biophysics PhD: Register (free) for the BPS Grad Fair. Get info on selecting/applying to schools. I'll be hosting the @BBSBwustl booth Nov 11, @DavePistonWUSTL Nov 12.
Virtual Graduate Fair - Students biophysics.org/store/product…
Excited for the start of #moet21!
🧬🧬🧬🧬🧬
Mechanisms of Eukaryotic Transcription @cshlmeetings.
Always learn a lot at this conference.
Eric Galburt retweeted
Hi, we are still actively looking for postdoc(s). Candidates with structural biology background or passion for microtubule/cilia are preferred. Please retweet.
Please RT: One postdoctoral position is available in my lab (zhangrui.wustl.edu) @WUSTLmed to study the structures and functions of native macromolecular complexes related to #microtubule #cilia and @cytoskeleton from various species including #parasites and human.
Eric Galburt retweeted
Interested in chromatin and pol II transcription? Check out this special issue: bit.ly/2Sx0L9f
Thanks to all reviewers, the team @JMolBiol and authors Arndt Decker @GalburtLab Gilmour Larson Liu @MusselmanLab Narlikar @NeugebauerKarla @PughLab @YuanHe_NWU Zhang
Eric Galburt retweeted
ICYMI: Our understanding of human pol II transcription has been transformed over the past few months. Remarkable progress thanks to cryoEM PIC structures from Yanhui Xu lab @CramerLab @TjianDarzacq @YuanHe_NWU. News/Views article here: go.nature.com/2SH3wEL
More structural details underlying DNA opening by the PIC! Beautiful visualizations of the intermediate DNA bubble we see in our single molecule magnetic tweezers.
pubmed.ncbi.nlm.nih.gov/2910…
It’s the year of the #PIC:
Yeast Pol II pre-initiation complex at 2.9 Å resolution defines a unique mechanism of initial DNA opening.
Tour-de-force by @S_Schilb with help from @shintoez & @c_dienemann.
Download the paper here: authors.elsevier.com/a/1dF84…
This looks interesting!
What does a single molecule feel when it crosses a phase boundary?
Find out here: biorxiv.org/content/10.1101/… Very much enjoyed this collaboration led by @BosseStefansson and myself, with Jonathan Bauermann, @WebersGroup and Frank Jülicher @csbdresden
Wunderschön! More absolutely gorgeous structural work from @CramerLab! Exciting to see structural data consistent with some of our kinetic and single-molecule work.
We present structures of (Mediator)-Pol II pre-initiation complexes at high resolution.
Feels great to arrive at a detailed understanding, incl. conformational changes in TFIIH translocase XPB during DNA opening.
PIC: nature.com/articles/s41586-0…
Mediator-PIC: nature.com/articles/s41586-0…
Eric Galburt retweeted
Its another @BBSBwustl #collaboration!
A fun and interesting collaboration with my colleagues @WUSM_BMB!
New paper from @AndreaSoranno and Roberto Galletto’s labs featuring work from @GalburtLab and myself. Telomeres, force experiments, DNA condensation, phase separation - what’s not to like?!