@PughLab

Translational Cancer Genomics Lab | Dr. Trevor Pugh, PhD, FACMG | Single-cell Genomics. Immunogenomics. Cell-free DNA.

 Toronto, ON
pughlab.org
Joined July 2012
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What happens to the bone marrow after chemotherapy? Very excited to share our new paper, featured on the cover of @BloodPortfolio, led by an incredibly talented student in my lab, Ximing Li! 🎉 ashpublications.org/blood/ar…

IFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy

Key PointsDOX remodels the BM niche, inducing arteriolar damage, MSC dysfunction, and sustained expansion of phenotypic HSCs.IFN-γ signaling from CD8+ T ce

ashpublications.org
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Great @TheACMG session today: “The New Era of Genomic Oncology” All-star cast of speakers including @PughLab & standing room only in one of the main conference ballrooms! I presented on “Novel Approaches to Cancer Profiling and Treatment Response Prediction Using Cell-Free DNA”
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Exciting new research in advanced melanoma shows sequencing T-cells can help predict and monitor response to adoptive cell transfer, a treatment using a patient’s own immune cells to attack cancer. Led by @PughLab & @MarcusButler_PM @UHN @pmcancercentre. doi.org/10.1186/s13073-025-0…
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🌟New Resource article Read about the pancancer landscape of cancer-specific cell-free DNA methylation and fragmentomic features from plasma samples from 1,294 patients ✒️Yong Zeng, @MatLupien, @PughLab, Housheng Hansen He & colleagues nature.com/articles/s43018-0…
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I'm happy to share this free link to our new paper on the perils of trying to find microbes in human cancers, which appeared today in @NatureCancer. Co-authors include Nobel laureate @barjammar and ancient DNA expert Eske Willerslev: rdcu.be/e4IaU
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Trevor Pugh (@PughLab), Brian Crompton (@bdcrompton), Paul Northcott, and Kara Maxwell (@KMaxwellLab) are developing an accurate, accessible blood test for patients with very high inherited cancer risk due to conditions such as Li-Fraumeni Syndrome. 🧬
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Thanks @BloodPortfolio #Blood for inviting me & @juanjogrcs to write this commentary: "Time to say adieu to FISH in myeloma diagnostics". ashpublications.org/blood/ar…. Here the link to the recent great effort from #IMF #Jill_Corre #Hervé_Avet_Loiseau ow.ly/mLnE50XXs2W #mmsm
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Registration is OPEN! 🧬 Join the CGC on January 27th for an essential webinar: "Guidelines for the testing and reporting of cytogenetic results for risk stratification of multiple myeloma." 🗓 Date: Tuesday, Jan 27, 2026 🕐 Time: 1:00 PM – 2:00 PM ET
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The Cancer Genomics Consortium (CGC) is looking for dedicated CGC members to join our newest Working Group: Clinical Implementation of Multimodal Liquid Biopsy Cancer Testing. Click here to apply: buff.ly/r6e5nG3 #CGCVolunteers #genomics #cancer #research #genetics
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Canada’s new government is investing big to attract world-class talent in science and technology — and become an innovation powerhouse.
Screenshot from an article of the Financial Post. The headline reads: Canada launches billion dollar plan to recruit top researchers.

ALT Screenshot from an article of the Financial Post. The headline reads: Canada launches billion dollar plan to recruit top researchers.

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Opinion | Peter Gilgan: Why I donated $50 million to Princess Margaret Hospital - Toronto Star apple.news/A64RqMtcvTcyy-plK…

Opinion | Peter Gilgan: Why I donated $50 million to Princess Margaret Hospital

We need a long-term commitment to make early detection a pillar of our national health strategy, which inspired my decision to make a $50 million gift to establish the Peter Gilgan Centre for Early...

apple.news
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Reminder to register for the upcoming webinar Circulating Tumor DNA as Diagnostic Tool in Oncology on December 11, 2025. Click here to register: buff.ly/5TrCKGl #CGCVolunteers #genomics #cancer #research #genetics #clinicaltesting #bioinformatics #cytogenetics #molecula
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Registration Now Open: The Cancer Genomics Consortium (CGC) invites you to attend Circulating Tumor DNA as Diagnostic Tool in Oncology on December 11, 2025. Click here to register: buff.ly/5TrCKGl #CGCVolunteers #genomics #cancer #research #genetics #clinicaltesting
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🚨 Excited to chair the AI Applications in Human Health session at the MAQC 8th Annual Conference to make AI clinically relevant and reproducible. Transparency and reproducibility aren’t optional, they’re the foundation for trustworthy AI in healthcare. themaqc.org
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Join us next week for "Transforming Tumor Methylation Profiling with Oxford Nanopore Direct DNA Sequencing" on October 28, 2025. Click here to learn more and register today: buff.ly/zOJmm4t
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WE'RE GOING TO THE WORLD SERIES!!!!! #WANTITALL
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Don't miss out! The new letter from the CGC President is here, sharing the latest vision and updates for the future of the Cancer Genomics Consortium. Read the full message now: buff.ly/HwoKEK5
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Honoured to be featured in Open Access Government! I shared how AI and biomarker discovery are transforming precision oncology, and why rethinking therapy response evaluation is essential to deliver truly personalized cancer care. Read more 👉 edition.pagesuite-profession…
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Pugh Lab retweeted
AACR
@AACR27 Sep 2025
Cancer Biology, Early Detection, and ctDNA: Meredith Irwin, Paul Northcott, Trevor Pugh, Loretta Lau, and Lea Surrey addressed this topic in a plenary session at the AACR Conference on Pediatric Cancer Research. #AACRpediatric25 @DrMeredithIrwin @PughLab
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Hey TeamUHN! Look up tonight!☝️ The CN Tower will be lit blue and red for UHN's Week of Gratitude — a city-wide thank you to those who deliver remarkable care, research, and education. 💙❤️ Say thank you at: uhn.network/SayThanks!

TeamUHN Week of Gratitude 2026 | Kudoboard

Kudoboard empowers users to celebrate the moments that matter.

uhn.kudoboard.com
CN Tower / Tour CN@TourCNTower22 Sep 2025
Tonight the #CNTower will be lit blue and red for Healthcare Heroes Week of Gratitude / Ce soir, la #TourCN sera illuminée en bleu et rouge pour la Semaine de reconnaissance des héros du secteur de la santé
Closeup of the #CNTower at night lit blue and red / Gros plan de la #TourCN illuminée en rouge et bleu la nuit.

ALT Closeup of the #CNTower at night lit blue and red / Gros plan de la #TourCN illuminée en rouge et bleu la nuit.

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