@FreddolinoLab

We study regulatory networks of bacteria 🦠 🧬🔬 💻 📈 *Student-run @umich @umichmedicine [email protected]

 Ann Arbor, MI
freddolino-lab.med.umich.edu
Joined May 2022
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  • Following78
  • Followers187
42Media
Lab outing at Wiard's orchard! Perfect fall weather for some warm cider and donuts with the lab
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Back from a wonderful visit to #UMichBiolChem, @UMichMedicine. Honored to be the 2024 Jourdian lecturer, hosted by dear friend @mcianfro and @PIHanson: "The George William Jourdian Lectureship is for a young rising star biochemist within the first 15 years of starting their career as an independent investigator." All thanks to the amazing work and dedication of @kellogg_liz lab. The sky is the limit for the ambitious and talented scientists I work with. They never give up in the face of a challenge & always a daily inspiration❤️ This is only the beginning, come build with us!
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Freddolino Lab retweeted
Sonya Royzenblat@Sonyalogy
22 Sep 2024
Is #BacNet2024 the greatest microbiology conference? I'll let the pictures speak for themselves. Thank you to everyone who made it special!
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Check out my latest work from @WatersLabMSU lab with our amazing collaborators Jeremy Schroeder @FreddolinoLab on how V. cholerae maintains its cyclic di-GMP levels to maintain the balance between motile and sessile forms. (1/3) biorxiv.org/content/10.1101/…

Negative feedback of cyclic di-GMP levels optimizes switching between sessile and motile lifestyles...

The signaling molecule cyclic di-GMP (cdG) controls the switch between bacterial motility and biofilm production, and fluctuations in cellular levels of cdG have been implicated in Vibrio cholerae...

biorxiv.org
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Hope you were able to check out Vivian's wonderful talk about how secondary metabolite production and chromatin structure are impacted by Lsr2 and LsrL #Phages2024
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Come hang out with the Freddolino lab at our posters! #phages2024
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Check out our section on Massively Multiplexed Mu Transposition in the second edition of 'Bacterial Chromatin'
Remus T. Dame@DameLab
22 Jul 2024
Very glad to see that the second edition of 'Bacterial Chromatin' (Methods in Molecular Biology) is now available: link.springer.com/book/10.10…

Bacterial Chromatin

link.springer.com
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Check out our new review looking at the spatio-temporal organization of the E. coli chromosome! journals.asm.org/doi/10.1128…

Spatio-temporal organization of the E. coli chromosome from base to cellular length scales | EcoSal...

Bacterial chromatin is shaped by an intricate interplay of the genetic material itself, with the cellular milieu of water, ions, and small molecules, plus a massive array of proteins that bind,...

journals.asm.org
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Our recent work with the @FreddolinoLab investigates the complex transcriptional regulation in E. coli during glucose and amino acid starvation. We uncover novel stress responsive chromatin-like structures, alongside transcription factor controlled sRNAs. biorxiv.org/content/10.1101/…

Multiscale regulation of nutrient stress responses in Escherichia coli from chromatin structure to...

Recent research has indicated the presence of heterochromatin-like regions of extended protein occupancy and transcriptional silencing of bacterial genomes. We utilized an integrative approach to...

biorxiv.org
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WOW, what a special time! Dr. Rucheng Diao has successfully defended their thesis! We are so proud of their work and respect the effort they put into everything they do (1/2) medicine.umich.edu/dept/dcmb…
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Rucheng will be starting a postdoc in April of this year at UIUC in Dr. Cari Vanderpool’s lab. There, they will study small RNAs in bacteria! (2/2)
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Happy Holidays! Our lab potluck was a great success, thank you all who attended and bringing a dish
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Freddolino trainees bring out the rotations students to rainy day lunch!
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We're having a wonderful time learning cool science and meeting with other scientists at #Phages2023
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Freddolino lab takes on rock climbing @planetrockgym. We had such a blast crushing boulders and monkeying around! The lab will definitely be coming back
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PhD Candidate @AndresEdian is checking in from the @BostonBacteria Meeting! Stop by and check out some awesome work on PTM regulation of the E. coli protein, Lrp.
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We're making new connections and hearing about novel technology at AGTD! Fantastic venue and conference!
GenomeTDCC@GenomeTDCC
7 Jun 2023
Advances in Genomic Technology Development with @genome_gov Genome Technology Program grantees in La Jolla, CA. Thank you @yeo_lab for hosting us
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Jeremy has spotted you. You have five minutes.
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Trainee lab brunch at Northside Grill celebrating the end of the semester!
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We have a new lab member! Vivian Ramirez is a first year PhD student in the Computational Medicine and Bioinformatics program here. (1/2)
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Vivian will be studying the regulatory effects of nucleoid associated proteins, lsr2 and lsrl, in cryptic biosynthetic gene clusters of Streptomyces venezuelae. (2/2)
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