@FraserLab

Fraser Lab @Stanford. We are interested in studying gene regulation - and we have a lab dog named Peanut.

 Stanford, California
web.stanford.edu/~hbfraser/
Joined August 2013
  • Tweets55
  • Following38
  • Followers307
4Media
✨ Kicking off this our Top Tweets Countdown is this paper by @StanfordPSY scientists including the @FraserLab, who generated a panel of tetrapoid stem cells by fusing human and chimpanzee #iPSCs. xitter.cf/organoidscience/status…
Organoid News
@organoidscience19 Mar 2021
Drs. Sergiu Pasca (@PascaStanford), Hunter Fraser (@FraserLab) & colleagues study species divergence in cerebral cortical development by differentiating cells into neural #organoids. 🧠 @nature go.nature.com/2P70rfm
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Checkout this cool paper by @AlexKSci @FraserLab et al Divergent patterns of selection on metabolite levels and gene expression bmcecolevol.biomedcentral.co…

Divergent patterns of selection on metabolite levels and gene expression

BMC Ecology and Evolution - Natural selection can act on multiple genes in the same pathway, leading to polygenic adaptation. For example, adaptive changes were found to down-regulate six genes...

link.springer.com
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It is really my privilege to be part of SLPA the amazing Latinx community at @Stanford shout-out to Fátima the other co-chair (xitter.cf/StanfordLPA/status/144…) and thanks to @LSRFdtn @StanfordCEHG & @FraserLab who have made my time here possible. ¡Gracias!
Stanford Latinx Postdoc Association (SLPA)@StanfordLPA5 Oct 2021
Sur Herrera Paredes (@sur_hp) from 🇲🇽 is our co-chair, and he studies bacterial genetic diversity to understand the genetic basis and evolutionary consequences of host-microbe interactions #LatinxSpotlight #LatinxScience #MiGente #diversitymatters #HispanicHeritageMonth
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Thrilled to share that I joined @WeizmannScience to start my own lab! We will study how gene regulation shaped human evolution: gokhmanlab.com. I am looking to recruit👩‍🔬👨‍🔬, so please RT!
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Check out our new work with @aleks_nivina @FraserLab & Chaitan Khosla out in @PNASNews. We find a new type of repetitive genetic element (GRINS) which is quite common in polyketide synthases, and plays a role in the evolution of these biosynthetic clusters pnas.org/content/118/26/e210…
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Excited to have Dr. Hunter @FraserLab @Stanford as our guest speaker on June 24! Join him for a virtual seminar at noon. All are welcome but you must register first at: bit.ly/Fraser_June24
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Research highlight from Nina Vogt: @FraserLab at Stanford has generated human-chimpanzee hybrid iPS cells and uses them to study divergence in gene regulation between these species. RH: nature.com/articles/s41592-0… Papers: nature.com/articles/s41586-0… nature.com/articles/s41588-0…
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Enjoyed this cool preprint from @Paedugar @rena3ban @FraserLab . Transcriptome diversity confounds expression estimates, important to consider in downstream analyses like DE. biorxiv.org/content/10.1101/…

Transcriptome diversity is a systematic source of bias in RNA-sequencing data

Background RNA sequencing has been widely used as an essential tool to probe gene expression. While standard practices have been established to analyze RNA-seq data, it is still challenging to detect...

biorxiv.org
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Studying archaic humans is hard! samples are degraded and RNA is long gone. To investigate archaic gene regulation, we measured the regulatory effect of each of the 14,000 variants that separate us from our closest relatives. See what we found👇elifesciences.org/articles/6…
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Drs. Sergiu Pasca (@PascaStanford), Hunter Fraser (@FraserLab) & colleagues study species divergence in cerebral cortical development by differentiating cells into neural #organoids. 🧠 @nature go.nature.com/2P70rfm
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New Nature paper supported by a Stanford Bio-X Interdisciplinary Initiatives Seed Grant – Stanford Bio-X affiliated faculty members Sergiu Pasca (@PascaStanford) and Hunter Fraser, with Stanford Bio-X Fellow Rachel Agoglia: news.stanford.edu/2021/03/17… Learn more in the video!
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Thrilled to share our latest paper where we used human-chimp hybrid cells to study the evolution of gene regulation! See thread👇 nature.com/articles/s41588-0…
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Rachel Agoglia's AMAZING work is out! Fantastic stuff by the @FraserLab. nature.com/articles/s41586-0…

Primate cell fusion disentangles gene regulatory divergence in neurodevelopment

Nature - Cortical organoids derived from tetraploid human–chimpanzee fused induced pluripotent stem cells provide a platform for untangling unique molecular features of human brain development.

nature.com
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👨: @FraserLab used human–chimpanzee hybrid #iPSCs to study gene expression separating us. 🐵: ? 👨: go.nature.com/3eKgWIW 🙉: Hedgehog...🦔 ?
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✨ Drs. Sergiu Pașca (@PascaStanford) and Hunter Fraser (@FraserLab) reveals a human-specific response to modulation of SSTR2 function in cortical #neurons in this new @nature paper. go.nature.com/2P70rfm
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#OnThisDay in 1859, Charles Darwin's landmark book 'On the Origin of Species' was first published. The work is one of the foundations of evolutionary biology, and one of the most important scientific works of the 19th century. #HistoryOfScience
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Can bacteria's hidden weapon take gene editing to the next level? Scientists @WeizmannScience @timlu @geochurch @fraserlab are exploring a new frontier in genetic manipulation. freeth.ink/38X6TNU
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CRISPR may one day have a challenger. Meet retrons—mysterious complexes of DNA, RNA, and protein. Not only are they also part of the bacterial immune arsenal that defeats viruses, but they have genome-editing potential, too. fcld.ly/zyrqkf9
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Excited to share our recent preprint where we experimentally measured how each of the variants unique to modern humans affects gene expression! A thread about some insights into recent human regulatory evolution biorxiv.org/content/10.1101/…

The cis-regulatory effects of modern human-specific variants

The Neanderthal and Denisovan genomes enabled the discovery of sequences that differ between modern and archaic humans, the majority of which are noncoding. However, our understanding of the regula...

biorxiv.org
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BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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