Clinician scientist. Voracious learner. Director of McGill Geriatric Cardiology Program. Creator of https://xitter.cf/t.co/PVflDwZCSD & https://xitter.cf/t.co/4IJWOncQte.

Joined January 2018
冠動脈疾患に対する心リハ:コクランのアップデート2026(パイプライン研究.2025NEJMを含むメタ解析) ・心リハは冠動脈疾患患者の全死亡(RR 0.86)、心筋梗塞(RR 0.72)、全入院(RR 0.65)のリスク低下に加え、QOL改善と良好な費用対効果。 Exercise‐based cardiac rehabilitation for coronary heart disease - Dibben, G - 2026 | Cochrane Library cochranelibrary.com/cdsr/doi…
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The most important briefings of the day. Karl Deisseroth, professor of bioengineering and of psychiatry and behavioral sciences, shares the news of his Nobel Prize with his kids.
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The phase 3 clinical trials table of AgingBiotech.info (top trials DB of AgingBiotech.info/trials) now updated thanks to work by @tliu44. - New approvals (eg Scholar Rock). - Failed ph3s marked as such. - Prev Ph2 programs now in ph3 added. The pipeline progresses (slowly).
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In our lecture series on aging, @FrailtyMD said something very instructive (paraphrasing here): "We have to make an extra effort to distinguish between frailty and multi-morbidity, otherwise, we won't be able to intervene early!" Majority of the deficit accumulation models, e-Frailty, ICD-based frailty indices, etc, measure cumulative comorbidity not frailty. Jon's imaging-based coreslicer (coreslicer.com) is very impressive!! @MichaelGNanna @heartwiselab #innovation
Multidimensional Aging Trajectories Preceding Cardiovascular Events: @JAMACardio 🥸 This from our field of CV aging - aging (functional decline) comes before CV events!! 😱 Aging and longevity research in CV disease is very important: @MichaelGNanna @Ajar_Kochar @DrAROrkaby @DEF_gericard @SimoneBiscaglia @GianlucaCampo78 👇👇👇👇
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Better communication isn't just "bedside manner" - it's a CLINICAL SKILL. 5 tangible ways to improve it in the latest #JACC article: jacc.org/doi/10.1016/j.jacc.… @hmkyale
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This week, a team of researchers quietly published in @JACCJournals one of the most profound studies of valvular heart disease in recent memory. The PREVUE-VALVE study used a decentralized, in-home echocardiography model to estimate the prevalence of valvular heart disease among U.S. adults aged 65–85. Importantly, this was not a clinic-based echo cohort; participants were recruited nationally and underwent comprehensive transthoracic echo in their homes, with studies interpreted by a core lab. That intentional design choice is critical: PREVUE-VALVE is a true prevalence study, accurately representing the true burden of valve disease in the U.S. population. The findings are striking: 8.2% of older Americans have moderate or greater valvular heart disease, and 18.4% have “clinically significant” disease when mild-to-moderate regurgitation is included. TR was the most common lesion, followed by AS, MR, AR, and MS. The burden rises sharply with age, reaching nearly 15% among adults aged 80–85. Extrapolated nationally, this means approximately 4.7 million Americans aged 65–85 currently have moderate or greater VHD, projected to increase to 6.5 million by 2060. Using the broader clinically significant definition, the number is already over 10 million and projected to approach 15 million. For structural heart programs, health systems, and policymakers, the message is clear: the valve disease burden is large, growing, and will require thoughtful planning around screening, access, and treatment capacity. Congratulations to @djc795, Michael 'Mickey' Brener MD MS, and all co-authors for a stunning glimpse into the present and future of valve disease! jacc.org/doi/epdf/10.1016/j.…
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New data in @Annals_Oncology: A target trial emulation of >229K obese, nondiabetic adults shows GLP-1RA use is associated with a 41% reduction in obesity-associated cancers compared to lifestyle modifications alone (HR 0.59). - Congratulations to Aparna Kamat, Arthur Hsu, @pedroramirezMD & entire @MethodistHosp team annalsofoncology.org/article… @SGO_org
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🧠 About 1 in 4 older people in hospital have dementia. ⚠️ But a lot of this has never been diagnosed. Older people with undiagnosed dementia are frequently admitted to hospital and discharged from hospital without any attempt to make the diagnosis or flag a potential diagnosis and arrange follow-up. This is a major missed opportunity - to use hospital admission as an opportunity to diagnose dementia where possible, or to flag likely dementia and then arrange follow-up. In this JAGS paper, Tan and colleagues describe a practical hospital-wide approach combining an electronic health record flag with nurse-administered 4AT and AD8 screening. Among 11,180 hospital encounters, 83.3% were screened; 18.0% had known dementia, 4.3% screened positive for potential dementia, and 9.0% for cognitive impairment. That matters because hospital admission is not just a point of acute care, but also an opportunity to identify major cognitive disorders that affect treatment, safety and discharge planning. The 4AT is useful here. The 4AT is the most validated and used *delirium* tool globally. But the 4AT also has built-in cognitive tests - so it provides a dual role as a delirium screener but also a tool to assist in detection of dementia. ☑️ This is relevant to the 4Ms - detecting both delirium and dementia/cognitive impairment is necessary - and the 4AT can help with both in the form of one 2-minute tool.
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Our new review out today on Testosterone, Creatine, HMB & other anabolic agents in ICU. ❓ Do you use creatine, testosterone, HMB or oxandrolone in your ICU or hospital patients? 🔖 journals.lww.com/co-critical… #ICURehab #FOAMcc #CriticalCare #ICUNutrition @ICUnutrition
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The mechanistic link between APOE4 and meningeal lymphatic clearance adds a crucial dimension to the 'drainage' hypothesis of AD. It’s particularly striking how this suggests that Alzheimer's might not just be a proteopathy of production, but a failure of vascular-lymphatic hydraulics. The sex-dimorphism mentioned here could finally explain the disproportionate burden on women beyond just longevity. This shifts the therapeutic horizon: are we looking at the future of 'lymphatic rejuvenation' for APOE4 carriers?
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In an international, randomized trial involving patients with acute venous thromboembolism, the risk of clinically relevant bleeding was significantly lower with apixaban than with rivaroxaban during the 3-month treatment period. Full COBRRA trial results: nejm.org/doi/full/10.1056/NE…
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How should LV filling pressures be estimated in patients with MAC? #ASEchoJC
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Multivitamin supplementation slows biological aging. Older adults taking a daily multivitamin for 2 years reduced their pace of epigenetic aging by 0.1–0.2 years compared with placebo. The effect was strongest in people with accelerated biological aging. Interestingly, cocoa flavanol supplementation showed no effect on epigenetic aging in the same trial. The effect is small, but it adds to evidence from the COSMOS trial, where multivitamin supplementation improved cognitive function, despite showing no clear benefits for cancer, cardiovascular disease, or all-cause mortality. The data challenge the idea that multivitamins are “completely useless," even if their benefits appear modest and context-dependent.
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Now in @JACCJournals: Insights from the FUTURE-HFII trial by #HFC members @FudimMarat, Tre Martyn et al. show ambulatory IVC congestion monitoring enabled physician-directed self-management and increased signal-driven interventions. sciencedirect.com/science/ar…
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BELIEVE it or not… this obesity trial suggests we may finally separate fat loss from muscle loss. In the BELIEVE trial (Nature Medicine): 🔹 Semaglutide alone → ~15.7% weight loss 🔹 Combination therapy → ~22% weight loss (~24 kg) 🔹 Total body fat ↓ ~46% 🔹 Visceral fat ↓ ~58% 🔹 Lean muscle largely preserved For decades, weight loss meant losing muscle + metabolic reserve. This approach targets appetite AND muscle biology simultaneously. If confirmed in outcomes trials, this could reshape how we think about: ❤️ cardiometabolic disease 💪 sarcopenic obesity 🫀 surgical risk & frailty We may be moving from weight loss → body composition medicine. #Obesity #CardioMetabolic #GLP1 #Semaglutide #Longevity #HeartHealth #PreventiveMedicine #NatureMedicine #MedTwitter #Cardiology #Endocrinology #DigitalHealth #FutureOfMedicine #HealthyAging #PrecisionMedicine
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Dietary polyphenols and sarcopenia: epigenetic mechanisms and geroscience perspectives for muscle health in aging frontiersin.org/journals/agi…
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Rethinking frailty, muscle, and protein through the lens of aging biology The dominant narrative around aging and frailty is deceptively simple and wrong: eat more protein + resistance exercise → activate mTOR → build more muscle → reduce frailty. linkedin.com/posts/lfontana6…
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🧵 For patients with complex health needs, the periods between clinical encounters are times of significant vulnerability, during which unobserved risks can escalate into acute events.
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Obesity in older adults is rising, and semaglutide & tirzepatide can bring significant weight loss and better heart, liver, and kidney health. Risks for older adults are muscle loss and functional decline. Policy must prioritize coverage + clinical trials for seniors to ensure access and safety. onlinelibrary.wiley.com/doi/…
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