Sustainable Metabolic Health and Fasting Strategist for High Performing Professionals | Private One on One Advisory | Certified Human Performance Nutritionist

Mumbai
Joined February 2010
🎙️ Beyond Protein — Muscle Is Strength for Everyday Life EP 02 - @drtanmoy shares why strength training & skeletal muscle matters for recovery from serious illness and surgery, preventing fatal fragility fractures and maintaining independence as we age. youtu.be/iWhZDze-OFA?si=MgJf…
1
3
1
8
543
Mishal Sequeira retweeted
When I'm in a performance review at work and they ask me where I see myself in ten years.
224
1,782
149
13,705
191,431
Mishal Sequeira retweeted
"How's your diet going?" "Fuck off"
581
7,592
459
81,970
1,006,309
Mishal Sequeira retweeted
Replying to @DoctorTro
Calories measure energy, but fructose still changes how the liver handles it. In controlled human work, fructose and sucrose roughly doubled the liver's fat production while the same amount of glucose did not. The type of sugar matters, not only the calorie total.
3
22
108
2,411
Prof Noakes @ProfTimNoakes credits the learning of LCHF from these books. Such a big pioneering name in the low-carb world but such a humble soul. @TheNoakesF
2
14
1
27
989
Mishal Sequeira retweeted
Eating breakfast won't help a person lose weight, and it can do the opposite. When adults in randomized trials were assigned to eat breakfast, they ate about 260 more calories per day than those assigned to skip it, and they ended up slightly heavier. The idea that breakfast "kick-starts" metabolism hasn't held up. The evidence is clear: if a person isn't hungry in the morning, there's no metabolic reason to force down a meal.
57
59
9
610
21,925
Mishal Sequeira retweeted
Replying to @hubermanlab
There's an older finding that fits this conversation well. In 1996, women with obesity had a much weaker GLP-1 response to carbohydrate than lean women, while their response to fat was normal. That points to a carb-specific problem, and it's why GLP-1 drugs work best when they're used to reduce carb cravings long enough to build new habits, like protein-centered meals and lifting. In one semaglutide trial, hunger and food preoccupation were back to placebo levels by week 40, so those habits need to be in place before the drug's effect on appetite fades.
1
2
1
29
1,936
Mishal Sequeira retweeted
Replying to @iam_preethi
This is why fasting insulin belongs in every PCOS workup. High insulin pushes the ovaries to make more testosterone, and it also lowers a protein that normally keeps testosterone in check, so more of it stays active. That excess testosterone gets in the way of normal ovulation. Beyond being a marker, high insulin is the primary driver.
7
13
100
10,001
Mishal Sequeira retweeted
I've been interested in the shift in protein consumption--people are eating more, which I appreciate. We used to believe there was a hard limit on how much protein the body could absorb in one sitting, usually about 20 to 30 grams. That idea mostly came from studies where muscle protein synthesis leveled off after a modest dose of whey after lifting. New evidence says that limit isn't so limited. When people ate 100 grams of protein after exercise, their muscles kept making new protein for more than 12 hours, longer and to a greater degree than after 25 grams, and very little of the extra protein was burned off as fuel. When it comes to protein, stop counting grams per meal and focus on the daily total. If a big protein dinner is what fits, eat it.
47
95
5
842
41,557
Mishal Sequeira retweeted
Replying to @WSJ @WSJopinion
Calories matter, but they don't all send the same hormonal signal. And hormones matter. Insulin decides whether your body is storing fat or burning it, and refined carbs drive insulin far more than protein or fat do. In a controlled feeding trial, people keeping weight off on a low-carb diet burned more energy than people eating the same calories on a high-carb diet.
7
4
79
2,238
Mishal Sequeira retweeted
145
5,302
203
41,473
743,679
Mishal Sequeira retweeted
Your legacy will live on forever. Om Shanti, Nana Patekar. 🤍
12
348
14
2,702
44,094
11 YEARS OF TYPE 2 DIABETES MEDICATION-FREE REMISSION On 27 September 2015, my reports showed: Fasting blood glucose: 152 mg/dL Post-meal blood glucose: 253 mg/dL On 6 October 2015, my HbA1c was 7.2%, confirming Type 2 diabetes. Now on 6th October 2026: HbA1c: 5.4% Fasting glucose: 88 mg/dL Fasting insulin: 5.84 µIU/mL 2-hour glucose: 97 mg/dL 2-hour insulin: 28 µIU/mL No medications. Sustained through a low-carb lifestyle, regular monitoring & long-term consistency. This is not a short-term improvement or one favourable report. It is more than a decade of maintaining Type 2 diabetes remission. The real achievement is not reaching remission but in sustaining it. More to come... – Metabolic Health India®
14
12
2
40
1,522
Cats will hear a noise you cannot hear, stare at something you cannot see, and then leave you alone in a room with it.
190
587
58
5,871
56,255
Mishal Sequeira retweeted
October is #BreastCancerAwareness month and you will see a lot of activities and noise around it, rightly so. I may sound a little old, whiny and cynical but we have been saying the same things over and over for years to raise awareness and so many workplaces include it in their HR activities for the health talk of the month, but I don’t see extended support provided to women and their families at their workplaces when they struggle and suffer with the commonest cancer in the world. I may also share a post or two about raising awareness in the month like every year, but sincerely wish we all did much more collectively round the year to raise awareness not just for the diagnosis and treatment but also for strengthening support systems for breast cancer patients, so that these #pinktober events are not reduced to just tokenism and PR activities. #DiaryOfAnOncologist
A thread on #BreastCancerAwareness #ThinkPink Breast cancer is now the most common cancer in women in India. In western countries 1 in 8 women develop breast cancer. In India with increasingly urban lifestyle choices we are fast catching up at alarming rates. 1/
4
9
2
40
1,780
Mishal Sequeira retweeted
Did you know that a fast actually increases your metabolic rate? It's a myth that your metabolism slows the moment you stop eating. Early in a fast, it actually does the opposite. As blood glucose tends to drift down when you stop eating, your body releases more norepinephrine (a close cousin of epinephrine/adrenaline), and your resting energy expenditure climbs up. In healthy adults who fasted for 84 hours, resting energy expenditure rose about 14% by day three, while norepinephrine more than doubled. Of course, the more adrenaline and its sibling rise, the more they inhibit insulin release. This further amplifies the metabolic rate effect, insofar as insulin slows metabolic rate very well. This is clearly not "starvation mode." There is simply a metabolic cost to your body mobilizing fuel and keeping you alive while you take a break from food. pubmed.ncbi.nlm.nih.gov/1083…
16
65
4
416
11,120
Mishal Sequeira retweeted
I fasted for 72 hours this week. Day 1 was easy. Day 2 was brutal. Day 3 was the complete opposite of what you’d expect. Here’s what happened:
30
14
1
329
39,546
Mishal Sequeira retweeted
9
49
9
356
8,365
Mishal Sequeira retweeted
Your gut doesn’t know that you have a deadline. It only knows the state your body is in. When you are constantly rushing, worrying, eating quickly, sleeping poorly or staying mentally switched on, digestion may not be your body’s priority. This is where the autonomic nervous system matters. The sympathetic system helps you act, focus and respond to stress. The parasympathetic system supports rest, digestion, recovery and elimination. You need both. The goal isn’t to “activate the vagus nerve” all day. The goal is autonomic flexibility, being able to move into action when needed and return to recovery when the threat is gone. Slow diaphragmatic breathing, humming, walking, adequate sleep and eating in a calmer state are simple ways to practise this. Sometimes improving digestion starts before the first bite. You don’t just digest food. You digest it in a physiological state.
1
2
163
Mishal Sequeira retweeted
We talk a lot about metabolic flexibility. But there is another flexibility we don’t talk about enough: Autonomic flexibility. Your body needs to move between: Sympathetic which is action, focus, alertness Parasympathetic which is rest, digestion, recovery Neither is “good” or “bad.” You need sympathetic activation to exercise, work, respond and perform. You need parasympathetic recovery to eat, digest, sleep and repair. The problem is not sympathetic activation. The problem is losing the ability to shift gears. A body that can respond to stress and then come back to calm has better regulation. This is why simple practices such as slow diaphragmatic breathing, humming, walking, good sleep and eating without rushing can matter. Not because they are magic “vagus nerve hacks.” Because we are training the body for flexibility. Just as metabolic flexibility is the ability to switch between fuel sources according to demand, autonomic flexibility is the ability to shift between activation and recovery according to demand. Health is not about staying in one state. Health is the ability to adapt.
2
3
1
16
774
Mishal Sequeira retweeted
Apart from the mis labelling of sugar the idea that besan in this food matrix transforms into a healthy heart health claim is baffling. 100% health. Pity they didn't use allulose instead of sugar. Then it could be a reasonably good energy ball.
1
2
152