@FChrisBennett

Microglia enthusiast and psychiatrist

 Philadelphia, PA
Joined May 2018
  • Tweets728
  • Following1.6K
  • Followers3.2K
8Media
We wanted a safe and specific way to replace microglia, so we created one.
Sonia Lombroso@Sonia_Lombroso31 Dec 2022
Ending 2022 on a high note with the Bennett Lab’s first paper! Excited to finally share this work! TLDR: We (@FChrisBennett and @BlurtonJonesLab) engineered an inhibitor-resistant human CSF1R variant that can be used for microglial replacement. 🧵 below.
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Soyon Hong@soyonhonglabAug 20
Excited to share our @Cell Perspective: Neurodegeneration as a Dysregulation of Neuroimmune Crosstalk, with @FChrisBennett @JennyNJiang & @ivanmarazzi! authors.elsevier.com/sd/arti…… We view NDD via NI crosstalk across scales: from synapses and glia to peripheral immunity (1/2)
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Soyon Hong@soyonhonglabAug 20
-understanding how NI crosstalk become dysregulated in NDD & how they might be restored offers powerful framework re: disease mechanisms & therapeutic opportunities. Thanks @ChanZuckerberg and the pioneering neuroimmunologists at the CZI workshop for shaping our thinking!
Soyon Hong@soyonhonglabAug 20
Excited to share our @Cell Perspective: Neurodegeneration as a Dysregulation of Neuroimmune Crosstalk, with @FChrisBennett @JennyNJiang & @ivanmarazzi! authors.elsevier.com/sd/arti…… We view NDD via NI crosstalk across scales: from synapses and glia to peripheral immunity (1/2)
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Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells dlvr.it/TPDLwc #genetherapy #celltherapy

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells

Microglia replacement holds broad therapeutic promise. Applying a transgenic, CSF1R inhibitor-resistant mouse line, Lombroso and colleagues introduce a new strategy for microglia replacement by...

cell.com
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CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies dlvr.it/TPDM43 #genetherapy #celltherapy

CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies

Chadarevian and colleagues demonstrate that CSF1R-G793A mice exhibit broad CSF1Rinhibitor resistance, enabling efficient microglia replacement following intraparenchymal, intracisternal, or bone...

cell.com
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Waggoner Lab@LabWaggoner14 Nov 2025
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells cell.com/molecular-therapy-f… cell.com/molecular-therapy-f… @MolTherapy @FChrisBennett @Sonia_Lombroso @BlurtonJonesLab @JPChadarevian @UCIrvine @Penn
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Microglia replacement via vascular delivery and no toxic preconditioning? Now THAT is something I can get excited about. In our new paper we find that microglia replacement can now be achieved by peripheral delivery w/ no irradiation or chemo required. 👉 doi.org/10.1016/j.ymthe.2025…
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Cody J. Smith@cssmity31 Oct 2024
We are excited that our work describing microglia cannibalism is now officially in press! journals.plos.org/plosbiolog… Stay tuned because we are on to the genetic mechanisms! 😀
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Thrilled to share new work from our lab led by ⁦@mitchkim_mw⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature nature.com/articles/s41586-0…

Endogenous self-peptides guard immune privilege of the central nervous system

Nature - Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.

nature.com
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Interested in studying type I interferonopathy? Here is a primer on existing tools from the self proclaimed "AGS supergroup". doi.org/10.1111/imr.13413

The prototypical interferonopathy: Aicardi‐Goutières syndrome from bedside to bench

Aicardi-Goutières syndrome (AGS) is a progressive genetic encephalopathy caused by pathogenic mutations in genes controlling cellular anti-viral responses and nucleic acid metabolism. The mutations...

onlinelibrary.wiley.com
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New paper ALERT!! @MaraCowen discovered and defined how conserved autism-associated genes modify a 'social' behavior in C. elegans!! So proud of her work in the lab! nature.com/articles/s41467-0…

Conserved autism-associated genes tune social feeding behavior in C. elegans

Nature Communications - C. elegans aggregate in large clumps during feeding. Here, the authors find conserved autism-associated genes mediate distinct molecular and circuit signaling components...

nature.com
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looking forward to tomorrow!!
Vollum Institute@VollumInstitute23 Oct 2024
The Vollum Seminar Series continues Thursday (10/24) with Dr. Jennifer Orthmann-Murphy presenting “Targeting glia for remyelination” at noon in M1441 of the Vollum. Hosted by Dr. Kelly Monk. #OHSUResearch can login & stream from link on our site: bit.ly/4dXx9pc
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Ophir Shalem@ophirshalem20 Oct 2024
Excited to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines. biorxiv.org/content/10.1101/…

CRISPR associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons resulting in...

The use of CRISPR-associated enzymes in iPSC-derived neurons for precise gene targeting and high-throughput gene perturbation screens offers great potential but presents unique challenges compared to...

biorxiv.org
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🚨Postdoc positions available🚨 If you have expertise in T cell biology (primarily TCR specificity/function) and/or in artificial intelligence, and if you would like to apply your knowledge to cool questions in #neuroimmunology, please email me for inquiry.
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One of the best ways to spend a sunny day in Philly is with these brilliant, creative,  and fun people! So honored to work with this awesome team! Happy #newpi Morris-Blanco Lab #strokeresearch – at Philadelphia, PA
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Congrats to @ChildrensPhila's Dr. Evan Weber, recipient of the @NIHDirector's New Innovator Award! Dr. Weber will pursue a novel approach to reprogram T cells with enhanced tumor killing function, paving the way for more efficacious #cancer therapeutics. @CHOPCancerCntr
NIH Common Fund@NIH_CommonFund8 Oct 2024
Early-stage investigators proposed #innovative high-impact research ideas for the @NIHDirector’s New Innovator Award. See the projects the awardees will pursue: commonfund.nih.gov/newinnova… #NIHHighRisk
Card with text reads: 2024 NIH Director's New Innovator Awardees. NIH Common Fund logo next to headshot of awardees.

ALT Card with text reads: 2024 NIH Director's New Innovator Awardees. NIH Common Fund logo next to headshot of awardees.

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So delighted that one of my very favorite scientists and people Dr Allen is a Pioneer Awardee (you heard it here first!) woooohooo! @salkinstitute
NIH Common Fund@NIH_CommonFund8 Oct 2024
The @NIHDirector's Pioneer Award funds researchers from all career stages pursuing groundbreaking new ideas to tackle significant challenges in #behavioral, #SocialScience, & #BiomedicalResearch. Meet this year’s awardees: commonfund.nih.gov/pioneer/A… #NIHHighRisk
Card with text reads: 2024 NIH Director's Pioneer Awardees. NIH Common Fund logo next to headshot of awardees.

ALT Card with text reads: 2024 NIH Director's Pioneer Awardees. NIH Common Fund logo next to headshot of awardees.

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!!!!!!!!!!!!!! 🔥🔥🔥🔥💯💯💯💯💯🔥🔥🔥🥂🥂🥂🥂🤪👍👍👍
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Lucas Cheadle@LucasCheadle3 Oct 2024
New protocols from Jessica Kahng and Andre Xavier for quantifying synapse engulfment by OPCs, based on foundational work from ⁦@SchaferLabUMass⁩ ⁦@stevens1lab⁩ ⁦@wonsukchung⁩ and others (1/4) nature.com/articles/s41596-0…

High-confidence and high-throughput quantification of synapse engulfment by oligodendrocyte...

Nature Protocols - An approach that combines a pH-sensitive synaptic biomarker expressed in vivo with the ex vivo staining of oligodendrocyte precursor cells enables quantification of synapse...

nature.com
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Chris Bennett retweeted
JIRico@JuanInclanRico1 Oct 2024
nature.com/articles/s41590-0… Itching can be annoying but could it also be beneficial? Maybe it’s your body 🚨 you of a secret invasion… Our freshly baked manuscript is trying to answer these and other neuron, 🪱 and macrophage-related questions. (1/n)🧵 👇🏼
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Tremendously proud to share my fellowship work, online today in @NatureMedicine. We tried to understand why CAR T therapy for AML doesn't work as well as we hoped it would, and how we can solve that. 👇🧵1/10 @PennMedicine @CHOP_Research @GillSaar nature.com/articles/s41591-0…

Cytokine-mediated CAR T therapy resistance in AML

Nature Medicine - In a phase 1 trial followed by translational analyses, patients with acute myeloid leukemia (AML) treated with chimeric antigen receptor (CAR) T cell therapy targeting CD123...

nature.com
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