
Publishing translational & clinical investigations of human health & disease focusing on #endocrine neoplasias & hormone-dependent #cancers. Owned by @soc_endo.
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ALT Targeting Src tyrosine kinase to enhance radioiodide uptake in breast cancer in Endocrine-Related Cancer. By Vikki L Poole et al. Published by Bioscientifica. Society for Endocrinology. Figure 1. Phosphorylated PBF represses RAIU in breast cancer cells. (A) Left – schematic of the interaction between NIS and PBF proteins tagged at the C-terminus with the NanoLuc luciferase subunits LgBiT and SmBiT, respectively. In close proximity, LgBiT and SmBiT form a functional enzyme that uses the substrate furimazine to produce a high-intensity, luminescent signal. Created using Alphafold (59, 60) and BioRender. Right – NanoBiT analysis of NIS:PBF interaction in MCF-7 cells, with bar graph showing results at 20 min post-addition of Nano-Glo live cell assay substrate. (B) Co-immunoprecipitation assay showing PBF-HA and NIS-MYC interaction in MCF-7 breast cancer cells. (C) Schematic of PBF highlighting the overlapping phosphorylation site...Endocrine-Related Cancer 32, 8; 10.1530/ERC-24-0312

ALT Endocrine-Related Cancer. Incoming Editor-in-Chief, Dr Karel Pacak. "It is a great honor to assume the role of Editor-in-Chief of Endocrine-Related Cancer, a journal fully committed to raising awareness of endocrine cancers among healthcare providers by supporting excellence in basic and clinical research, high-quality studies, and evidence-based guidelines." Published by Bioscientifica. Society for Endocrinology.


















