Physician scientist at Indiana University
Indianapolis, IN
Joined June 2018
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3. Risk scores like HbA1c and metabolic indices performed better in adults
4. Unique patterns suggest a need for age-tailored screening and follow-up
As always, such a pleasure to work with Erin Templeman from the @UniofExeter team, @RAOram, and Lauric Ferrat, as well as an excellent team of collaborators like @cevansmo @catespeake and others who are not on this platform. @IUSweetTweets
Super excited this paper on islet autoantibody positive adults is finally online- we analyzed screening and #T1D progression in 100K adult relatives screened as part of @T1D_TrialNet . Available at: bit.ly/4md4scn
We found important differences exist in screening and progression amongst children and adults. For example:
1. Adults were more likely to screen single Ab positive compared to kids
Really excited to share this super translational project from rockstar @chaipoorva ! Islets and T cells and EVs- what more could you want ❤️?
Beta cell extracellular vesicles carry PD-L1 and suppress CD8+ T cells. EV PD-L1 is increased in AAB+ individuals, correlating with residual beta cell function. Potential #biomarker for #T1D heterogeneity. #Diabetes @IUSweetTweets @emksims @chaipoorva tinyurl.com/4pe2hbvb
Should be a good one!
Join @TeresaMastracci , @claus_jorgensen , Maureen Gannon, and me at the Gordon Research Conference (GRC) on Pancreatic Diseases in June - "where the endocrine and exocrine pancreas meet". Registration is now open grc.org/pancreatic-diseases-…
Excited to work with this awesome team!
Thrilled to share our study: Risk associated with single autoantibody shifts after age 10, with men at higher T1D risk. Thanks to @EmKsims, @RAOram, @FerratLauric, and @T1D_TrialNet for their support. Read full press release here: shorturl.at/QojjQ #T1D #DiabetesResearch
Emily K. Sims retweeted
👋Meet us in #Indianapolis for our Complimentary CE Dinner Meeting on #Type1Diabetes on Monday, June 17th!
➡️ ow.ly/qakt50SelC2
@EmKSims
#Diabetes #ContinuingEducation #HealthcareProfessionals #Continuingprofessionaleducation #FOAMed #endocrinology
Emily K. Sims retweeted
Congrats to the global experts recognized as 2024 @WIELDvoice Trailblazers, especially @IUMedSchool Drs. Evans-Molina & DiMeglio and @EliLillyandCo Dr. Gimeno. We're proud and fortunate to have many female leaders in diabetes making an impact in Indiana! womenleadingdiabetes.com/dia…
Great work by @JacobsenLM and @Heba_T1D supporting the idea that metabolic endpoints can give us a quick readout of T1D disease modification. And we know based on @DrPeteTaylor and Colin Dayan's data that these changes have clinical relevance for our patients with T1D!
@T1D_TrialNet identifies earlier trial end points that demonstrate a beneficial treatment effect at 6 months and predict benefit out to 12 months. This could allow for shorter early phase trials or adaptive designs. @ADA_Pubs
Read Here➡️doi.org/10.2337/dc24-0171
ALT Graphical Abstract
Super excited for one of the best meetings of the year!
Registration is now open to attend the 20th Immunology of Diabetes Society Congress in Bruges, Belgium on Nov 4-8, 2024! Learn more about this year's program, register and submit an abstract by visiting idsbruges2024.com.
#T1DResearch #DiabetesResearch #IDS2024
Do metabolic measures perform similarly for predicting T1D vs. assessing immunotherapy? Not necessarily. However, combined glucose and C-peptide measures were consistent performers for both purposes. Check out at bit.ly/482qeIc ! @T1D_TrialNet @IUSweetTweets
Emily K. Sims retweeted
Attending #nPOD2024! Come to our @WIELDvoice breakfast panel where we discuss opportunities & barriers to leadership.
Attending nPOD (npod.org/agenda/)? Then attend our breakfast panel on barriers to leadership as well! #nPOD2024 @LinnemannLab @rmirmira @jessdunnephd @gFousteri @TseHubert @DiabetesnPOD
So excited to see where this important work goes!
Thrilled to represent @IUDeptPeds and co-lead the newly funded Heartland Children’s Nutrition Collaborative with @ssimsek22 from @PurdueFoodSci. We're extremely grateful for the Ricks Family Foundation's investment in pediatric health and precision nutrition research
Emily K. Sims retweeted
This was a very fun project to work on. I'd like to congratulate the whole team, in special Milene Vallejo (not on Twitter) for the hard work. @smpowell16 @byu_sam @EmKSims @MirmiraLab @rmirmira @uabmedicine @BYU @IUSweetTweets @sciencePNNL @OmicsPNNL @UChicagoMed (6/n)
Bestill my❤️! Truly bench to bedside work funded by @JDRFResearch showing that β cell drug targets may stabilize insulin secretion in T1D! And I get to work with @rmirmira and @DoctorDiMeglio ! bit.ly/46QZJWz . Thread with TLDR to follow:
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(6/6) TLDR: Drugs targeting beta cell health may have potential as agents in a combination regimen to improve insulin secretion in T1D. Next step? Fully powered TADPOL trial in new onset T1D! Find out more at: bit.ly/3tY8QpT