The TRAIN Study Hypothesis To determine whether a “liberal” strategy of maintaining Hb concentrations above 9 g/dL would result in a different neurological outcome when compared to a “restrictive” approach to red-cell transfusion to avoid hemoglobin concentrations < 7 g/dL in critically ill anemic patients (i.e. Hb ≤ 9 g/dL) with acute brain injury Prospective, multicenter phase III, two-arm, randomized, investigator-initiated, superiority, pragmatic and open-label randomized trial Study protocol trialsjournal.biomedcentral.… #LIVES2024

THIRD HOT TOPIC at #LIVES2024 3. Frequency of Screening and Spontaneous Breathing Trial Techniques: A Factorial Randomized Trial @KarenBurnsk jamanetwork.com/journals/jam…

Hot topic session @ESICM #lives2024 Moderators @KBibbinsDomingo, @JAMA_current @ElieAzoulay5 , @ESICM #DerekAngus, @JeffDrazen , @NEJM

TO SUM UP The PROs of PAC 💎Full hemodynamic evaluation 💎Pulmonary artery pressure (and nature of PAH) 💎💎particularly helpful in RV failure/PAH The CONs of PAC 🤔 Invasive 🤔 For many variables, similar information is provided by other techniques The PROs of TPTD 💎Minimally invasive 💎 Global hemodynamic evaluation 💎EVLW measurements The CONs of TPTD 🤔 Calibration required 🤔 No difference between RV/LV volumes 🤔 No pulmonary artery pressure 🤔 Arterial cath complications #LIVES2024