An #OpenAccess, peer-reviewed journal publishing clinical #casereports on common and rare conditions in all areas of #endocrinology, #diabetes & #metabolism.

Joined May 2013
Can lifestyle interventions induce glycaemic control in newly diagnosed T2DM w/ significantly elevated HbA1c? A new report describes a man w/ newly diagnosed T2DM who achieved near‑normal glycaemic control after a structured lifestyle intervention. 🔗doi.org/10.1530/EDM-25-0188
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A new case report by Hiroki Takizawa et al. describes 3 patients whose alcohol consumption decreased and whose metabolic risk factors and liver function improved after treatment with tirzepatide. Read the full report: doi.org/10.1530/EDM-26-0002
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Early diagnosis of ectopic adrenocorticotropic hormone (ACTH)‑dependent Cushing’s syndrome is vital, yet often delayed. A new case report shows how multidisciplinary care, 68Ga‑DOTATOC PET‑CT & biochemical control enabled full clinical recovery. 🔗doi.org/10.1530/EDM-25-0166
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Diabetic striatopathy (DS) is a rare but important neurological complication. A new case report describes a presentation of an elderly woman with no known diabetes, yet presented with marked hyperglycaemia & imaging consistent with DS. 🔗doi.org/10.1530/EDM-25-0118
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A new case report by Aya Eladl et al. contributes a valuable description of primary adrenal lymphoma (PAL) - a rare malignancy - discussing key aspects of PAL such as demographics, pathogenesis, diagnosis, management, and prognosis. Read the report: doi.org/10.1530/EDM-25-0148
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A new case report by Mhd Kutaiba Albuni et al. describes the first documented instance of DKA as the initial presentation of hepatogenous diabetes in a patient with alcoholic cirrhosis & no prior history of diabetes or pre‑diabetes. Read the full report: doi.org/10.1530/EDM-25-0088
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A new report presents a unique case of an adult female who developed autoimmune hyperthyroidism following haematopoietic stem cell transplant (HSCT) for multiple sclerosis. She was diagnosed with Graves’ disease approximately 10–12 months post-HSCT. 🔗doi.org/10.1530/EDM-25-0162
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Shozo Miyauchi et al. highlight the potential pathogenic role of APOA5 mutations in LPL-related hypertriglyceridemia, describing a case of primary hypertriglyceridemia associated with a rare APOA5 c.553G>T missense mutation. doi.org/10.1530/EDM-25-0084
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A new case report by Patrick McCluskey et al. presents the first description of an unusual onset of rapidly progressive diabetic retinopathy in a pregnant woman with ABCC8-MODY. Read the full report: doi.org/10.1530/EDM-25-0149
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Does ‘natural’ mean ‘safe’? A case report describes secondary adrenal insufficiency linked to ~950 mg/day ashwagandha use. The report calls for health authorities to provide guidelines for herbal products, given the risks linked to 'natural' remedies. doi.org/10.1530/EDM-25-0076
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EDMCaseReports retweeted
Pleased to share our newly published case series on RFX6-MODY, highlighting clinical considerations in pregnancy and the first documented use of tirzepatide post pregnancy in this rare MODY subtype. Thanks to all my co-authors! – at Wallasey, England
RFX6-MODY is a MODY subtype, with limited management guidance, particularly in pregnancy. A new case series by Prethivan Pillai Gopalakrishnan et al. offers insight into clinical features & management of two patients diagnosed during pregnancy. 🔓doi.org/10.1530/EDM-25-0142 #MODY
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RFX6-MODY is a MODY subtype, with limited management guidance, particularly in pregnancy. A new case series by Prethivan Pillai Gopalakrishnan et al. offers insight into clinical features & management of two patients diagnosed during pregnancy. 🔓doi.org/10.1530/EDM-25-0142 #MODY
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Papillary thyroid carcinoma arising within a thyroglossal duct cyst is rare. A new Peruvian case series by José Luis Paz‑Ibarra et al. reports 3 adults who presented with progressive midline cervical masses, which were ultimately confirmed as PTC. 🔓 doi.org/10.1530/EDM-25-0139
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New case report: A 12‑year‑old with late‑onset panhypopituitarism and distal arthrogryposis showed improvements in growth velocity and predicted adult height on weekly lonapegsomatropin (Skytrofa) without without worsening arthrogryposis Read the report: doi.org/10.1530/EDM-25-0146
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A new case report by Aparajita Roy and Kieran Mullins links chronic liquorice intake to severe hypokalaemia, metabolic alkalosis & QT prolongation - highlighting the importance of thorough dietary histories. Explore the full report: doi.org/10.1530/EDM-25-0120
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A new report by Annabelle G Hayes & Morton G Burt describes an asymptomatic patient with a giant composite phaeochromocytoma (PCC). The case suggests catechol‑O‑methyltransferase may inactivate catecholamines within PCC, allowing silent tumour growth. 🔗doi.org/10.1530/EDM-25-0116
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💫 This year we've had the privilege of publishing a diverse collection of reports, from rare conditions to practical guidance that supports care. Thanks for your contributions that enable us to advance clinical practice & improve patient care. We wish you a healthy 2026🥂
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New Case: 55‑year‑old woman with large adrenal mass & plasma normetanephrine 8,500 ng/L, yet normotensive. After α/β blockade, laparoscopic adrenalectomy confirmed pheochromocytoma. A reminder to consider pheochromocytoma in all adrenal incidentalomas. doi.org/10.1530/EDM-25-0064
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Webb-Dattani syndrome (WEDAS) is an exceptionally rare autosomal recessive disorder caused by an ARNT2 pathogenic variant. J.S. Alyami, W.M. Almistehi, and K.I. Alkanhal describe the longest reported survival to date of a 17-year-old girl. doi.org/10.1530/EDM-25-0114
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