@DutchakLab
Joined October 2018
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Can we target the drivers of genetic epilepsy? Our new preprint shows RAPTOR-targeting ASOs reduce pathological mTORC1 activity, normalize neuronal hyperexcitability, and significantly extend survival in GATOR1-deficient mice. biorxiv.org/content/10.64898… #Epilepsy #Neuroscience

RAPTOR-targeted Antisense Oligonucleotides Restrict Pathological mTORC1 Activity in GATOR1-depend...

Loss-of-function mutations in the GATOR1 complex (NPRL2, NPRL3, and DEPDC5) are among the most common genetic causes of epilepsy. These mutations impair amino acid-dependent regulation of mTORC1 and...

biorxiv.org
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Could amino acid sensing determine the metabolic state of mature astrocytes and contribute to seizure susceptibility? Excited to share our new EMBO Reports study. Many thanks to an incredible team of collaborators and trainees. link.springer.com/article/10…

GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter...

EMBO Reports - GATOR1 is an evolutionarily-conserved negative regulator of mTORC1-dependent signal transduction with pathogenic mutations linked to epilepsy, infantile spasms, and autism spectrum...

link.springer.com
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Special thanks to @BrainCanada, @CIHR_IRSC and @NSERC_CRSNG for supporting our research and trainee opportunities.
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I am delighted to share our new publication! Huge thanks to Laetitia Marcadet, Marie Pelaez, and all of our outstanding co-authors for their contributions to this work. academic.oup.com/brain/advan…

Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and...

ALS leads to loss of motor neurons, muscle atrophy and systemic energy imbalance. Marcadet and Pelaez et al. report lipid droplet accumulation and peroxida

academic.oup.com
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Open Call: Newly funded graduate and post-doc positions available to research the convergence of nutrient signaling and genetics contributing to seizures, in Canada. #NIH #StudyAbroad #BrainResearch #epilepsy #MolecularNeuroscience cervo.ulaval.ca/en/profile/p…
DutchakLab@DutchakLab2 Sep 2021
Interested in mTORC1 and nutrient signaling mechanisms? New graduate student positions are available in our lab. #mTORC1 #nutrientsignaling #neuroscience #epilepsy
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Grâce à une subvention Futurs leaders de la Fondation familiale Arrell, Paul A. Dutchak explore le lien entre la nutrition et les voies cérébrales. Cette recherche sur l'épilepsie et l'autisme vise à développer des stratégies nutritionnelles pour réduire les crises.
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12th Annual Tuberous Sclerosis Complex Global Awareness Day Scheduled for May 15 Learn more: ow.ly/9t9g50RtoFr

12th Annual Tuberous Sclerosis Complex Global Awareness Day Scheduled for May 15

/PRNewswire/ -- On May 15, the TSC Alliance® will join tuberous sclerosis complex (TSC) organizations around the world to observe the 12th Annual TSC Global...

prnewswire.com
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Shout out to ALL person touched by the #rareepilepsies We stand with you on #EpilepsyDay and everyday! @IlaeWeb @IntEpilepsyDay @IBESocialMedia @EpiCARE_ERN @geneticepilepsy
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Congrats to all those involved in our dissection of epilepsy-linked mutations in GATOR1 and their influence on canonical PI3K:mTORC1 function! Stepping through the web of cell signaling to understand disease. #CERVO_ULaval #Universitelaval #neuroscience mdpi.com/1422-0067/25/4/2068

GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1

GATOR1 (GAP Activity TOward Rag 1) is an evolutionarily conserved GTPase-activating protein complex that controls the activity of mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino...

mdpi.com
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Un grand merci pour votre soutien à notre programme de recherche! @Pierre_Lavoie @rdmm_social #CERVO #CERVO_ULaval fondationgdpl.com/qui-nous-a…
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Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation - Journal of Biological Chemistry jbc.org/article/S0021-9258(2…

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin...

Heterozygous GRN (progranulin) mutations cause frontotemporal dementia (FTD) due to haploinsufficiency, and increasing progranulin levels is a major therapeutic goal. Several microRNAs, including...

jbc.org
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I love these little pr*cks. Support @SickKids today.
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Tenure track Assistant Professor faculty position open at @UCBerkeley in nutrient signaling and metabolic biology (broadly defined). Metabolite sensing, regulation, signaling, flux, disease, etc. Please repost and help me get the word out. 😀 nature.com/naturecareers/job…

Assistant Professor - Nutrient Signaling - Department of Nutritional Sciences and Toxicology -...

USB seeks applications for a tenure track Assistant Professor faculty position, in the broadly defined area of Nutrient Signaling.

nature.com
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Happy National Epilepsy Day to our friends in India 🇮🇳! DYKT that conservative estimations suggest that there are over 12 MILLION people with epilepsy in India? #EpilepsyAwareness #EpilepsyAwarenessMonth #NEAM
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Structural changes in motor neurons expressing FUSR521G precede motor impairment and other pathological features of ALS. Well done Mari @mcpelaez_ @silviapozzi81 @DutchakLab and colleagues! link.springer.com/article/10…

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by...

Acta Neuropathologica Communications - Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related neurodegenerative diseases that belong to a common disease spectrum based on...

link.springer.com
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DutchakLab retweeted
CERVO@CERVO_ULaval21 Oct 2022
PhD @ CERVO is an international graduate student recruitment competition to find outstanding students who want to study Neuroscience. To learn more and to submit an application, visit cervo.ulaval.ca/en/phd
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DutchakLab retweeted
CERVO@CERVO_ULaval21 Oct 2022
PhD @ CERVO est une compétition internationale de recrutement qui vise à identifier des étudiants exceptionnels intéressés à faire un Ph.D. en neuroscience. Détails et application ici: cervo.ulaval.ca/fr/phd
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Our latest review is online! Check it out: Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease frontiersin.org/articles/10.… #neuroscience #ALS #dementia
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Options for graduate students at ULaval, Canada. #scienceforukraine frq.gouv.qc.ca/programme/bou…

Bourses d’accueil pour la communauté étudiante ukrainienne et russe

frq.gouv.qc.ca
youtube.com/watch?v=Ns9qfshR… Congrats Imane! #CERVO #Ulaval

Imane Hadj Aissa - Centre de recherche CERVO

Fondation CERVO - Boursiers Desjardins 2022

youtube.com
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